Novel hydrogel particles and their IPN films as drug delivery systems with antibacterial properties

Silan, Coşkun; Akçalı, Alper; Otkun, Metin; Özbey, Nilgun; Bütün, Sultan; Özay, Özgür; Şahiner, Nurettin

doi:10.1016/j.colsurfb.2011.09.024

Cited by 55 publications

(16 citation statements)

References 25 publications

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“…However, the consumption of Ag + cations with the fast release rate would eventually decrease the antimicrobial activity. Unlike metal NPs, some polymeric TNTC TNTC TNTC TNTC TNTC TNTC 24 × 10 particles could exert antimicrobial effect without the consumption problem (32,33). In this regard, it would be better to exert long-term antimicrobial effect by controlling the release of Ag + cations.…”

Section: Resultsmentioning

confidence: 99%

“…In this regard, it would be better to exert long-term antimicrobial effect by controlling the release of Ag + cations. Since the release rate of the drug in polymer gels can be engineered by the hydrophilicity of the gel matrix (33), the adjustment of chemical nature as well as physical structures could optimize the diffusion of Ag + cations for effective antibacterial effect with prolonged efficacy.…”

Section: Resultsmentioning

confidence: 99%

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Development of silver nanoparticle-based hydrogel composites for antimicrobial activity

Zakia

Koo

Kim

et al. 2020

Green Chemistry Letters and Reviews

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2020) Development of silver nanoparticle-based hydrogel composites for antimicrobial activity, Green Chemistry Letters and Reviews, 13:1, 34-40, ABSTRACT Antimicrobial function of Ag nanoparticles (NPs) has a strong correlation with the released Ag + cations that are produced by oxidation of Ag NPs in a solution state under ambient condition. Therefore, in order to develop anti-infective materials for biomedical applications, one needs to include Ag NPs inside biocompatible materials, which can allow slow release of Ag + cations. Hydrogels of natural polymers could be an ideal choice for the purpose because (a) the physicochemical properties of hydrogels resemble with biological tissue, and (b) the inclusion of Ag NPs inside hydrogels prevents the direct release of Ag NPs, while allowing the release of Ag + cations out of the hydrogels. In this regard, we present a simple strategy for producing Ag NPscontaining hydrogel based on natural alginate polymers. The chemical modification of alginate, blending with Ag NPs, gelation by photo-crosslinking process have been discussed in connection with antimicrobial reaction on model bacterium.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Development of silver nanoparticle-based hydrogel composites for antimicrobial activity

Zakia

Koo

Kim

et al. 2020

Green Chemistry Letters and Reviews

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“…In recent years, new antimicrobial materials are sought by many researchers for various applications such as on food packaging, food storage, biomedical fields including hygienic applications, healthcare products, and so on. Therefore, many investigations have been completed on the advancement of antimicrobial and/or antibacterial materials using polymers possessing positive charges naturally or by chemical modification through covalent attachment of cationic groups [12][13][14][15], copper oxide nanoparticles [16], natural polymers such as quercetin [17], rutin [18], chitosan [19], polyethyeneimine multilayers [20], and silver nanoparticles [21,22]. It has been suggested that the mechanism for the antibacterial effect of polymeric hydrogels is related to electrostatic interaction between the positively-charged antibacterial polymeric hydrogel and negatively-charged bacterial cell walls [14,23].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, hydrogel based materials have recently gained great attention for applications in drug delivery [6,7], separation and purification [8,9], biomedical fields [10][11][12] and so on.…”

Section: Introductionmentioning

confidence: 99%

The synthesis of desired functional groups on PEI microgel particles for biomedical and environmental applications

Şahiner

Demirci

Şahiner

et al. 2015

Applied Surface Science

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“…The quaternization of pyridine ring of PVP is an effective way of modifying the polymer structure to obtain side chains with different functional groups, graft polymers, or even gels . In the last decades, this quaternary ammonium group containing PVP (quaternized PVP) has been used in several studies for antibacterial purposes as a soluble polymer, gel, or coating . Although polycations containing quaternary ammonium groups have proven to exhibit inherent antibacterial effect, they may cause toxicity to human or animal cells .…”

Section: Introductionmentioning

confidence: 99%

Core‐crosslinking as a pathway to develop inherently antibacterial polymeric micelles

Kadayifci

Gökkaya

Topuzoğulları

et al. 2019

J of Applied Polymer Sci

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Positively charged polymeric materials have been an alternative to combat bacteria as they exhibit inherently antibacterial potency via bacteria membrane disruption. In this study, we report facile preparation of positively charged core‐crosslinked polymeric micelles with inherent antibacterial properties. Spherical micelles were prepared by self‐assembling of poly(4‐vinylpyridine)‐b‐(oligoethylene glycol methyl ether methacrylate) copolymer in aqueous solution. Herein, quaternization reaction was utilized for the first time to core crosslink the micelles through the pyridine rings utilizing their hydrophobic core and thus resulting positively charged nanostructures. Dynamic light scattering (DLS) results identified that the micelles have an average hydrodynamic diameter of 114 nm with a polydispersity index ranging between 0.105 and 0.114. The electrophoretic light scattering (ELS) measurements demonstrated that the micelles have zeta potential values ranging from +38 to +63 mV. It was evident from both ELS and DLS results that the micelles in solution exhibit long‐term stability as the samples were able to maintain their size and charge even after a year of storage. Further, the micelles exhibited inherently antibacterial activity against Escherichia coli and furthermore, this antibacterial efficacy was sustained over a period of 1 year. These stable core‐crosslinked micelles are proposed to have great potential as antibacterial materials for long‐term applications. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48393.

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Novel hydrogel particles and their IPN films as drug delivery systems with antibacterial properties

Cited by 55 publications

References 25 publications

Development of silver nanoparticle-based hydrogel composites for antimicrobial activity

Development of silver nanoparticle-based hydrogel composites for antimicrobial activity

The synthesis of desired functional groups on PEI microgel particles for biomedical and environmental applications

Core‐crosslinking as a pathway to develop inherently antibacterial polymeric micelles

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