Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field

Matsumine, Akihiko; Kusuzaki, Katsuyuki; Matsubara, Takehiro; Shintani, Ken; Satonaka, Haruhiko; Wakabayashi, Tetsushi; Miyazaki, Shinichi; Morita, Kenichi; Takegami, Kenji; Uchida, Atsushi

doi:10.1007/s10585-007-9068-8

Cited by 76 publications

(57 citation statements)

References 30 publications

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“…For example, Kim and co-workers [7] have obtained microspheres of Fe 3 O 4 encapsulated with chitosan as a MRI image contrast, while Jain and co-workers [8] obtained magnetic nanoparticles coated with Oleic-Pluronic for sustained delivery of cancer agents. Matsumine and co-workers [9] have developed a new hyperthermic treatment modality using magnetic materials (calcium phosphate cement containing Fe 3 O 4 ) for metastatic bone tumors. In this sense, biological molecules are important to change the magnetic component into a bio-inert composite.…”

mentioning

confidence: 99%

New ferrimagnetic biocomposite film based in collagen and yttrium iron garnet

Figueiró¹,

Mallmann²,

Góes³

et al. 2010

Express Polym. Lett.

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In recent years a great interest in the study of the association of magnetic with biological material for bioapplications has been observed in the literature. This work analyses the development of new magnetic biocomposite films from a magnetic ferrite and a biopolymer. Magnetic and dielectric properties of Y3Fe5O12 (YIG)/collagen composite films were studied as a function of the YIG concentration. This biocomposite was also characterized by Infrared Spectroscopy (IR), Thermal Analysis (DSC and TG) and scanning electron microspcopic (SEM) methods. The magnetization and dielectric measurements were performed at room temperature. The results demonstrated that ferrimagnetic garnet (YIG) and collagen (Col) can be used to obtain a homogeneous composite. All the composite films showed a ferromagnetic behavior and they were characterized as a soft magnet material. These results show that Col-YIG biocomposites are biological films with magnetic properties that can be employed as a versatile performance materials, due to their flexible dielectric and magnetic features. They could be used as electronic devices in biological applications

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mentioning

confidence: 99%

New ferrimagnetic biocomposite film based in collagen and yttrium iron garnet

Figueiró¹,

Mallmann²,

Góes³

et al. 2010

Express Polym. Lett.

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“…The material was grounded on a Fritsch Pulverisette 6 (Fristsch GmbH, Idar-Oberstein, Germany) planetary mill in sealed stainless steel vials (221.69 cm 3 ) and balls (ø10 mm) under air in weight ratio 1/9 (wt. of mixture powder/wt.…”

Section: Ferrimagnetic Particlementioning

confidence: 99%

“…Kim et al [1] have obtained microspheres of Fe 3 O 4 encapsulated with chitosan as a MRI image contrast, while Jain et al [2] obtained magnetic nanoparticles coated with Oleic-Pluronic for sustained delivery of cancer agents. Matsumine et al [3] have developed a novel hyperthermic treatment modality using magnetic materials (calcium phosphate cement containing Fe 3 O 4 ) for metastatic bone tumors. In this sense, biological molecules are important to begin the magnetic component in a bio-inert composite.…”

Section: Introductionmentioning

confidence: 99%

Microstructure and magneto-dielectric properties of the chitosan/gelatin-YIG biocomposites

Mallmann¹,

Góes²,

Figueiró³

et al. 2011

Express Polym. Lett.

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Abstract. This work is devoted to the preparation of yttrium iron garnet (YIG) ferrimagnetic biocomposites based in biodegradable chitosan and gelatin. The aim was to produce composite films containing controlled amounts of YIG to obtain a new biological material with magneto-dielectric features. Structural characterization of the biocomposites was made by scanning electron microscopy, X-ray diffraction, infrared absorption spectroscopy and thermal analysis, while the dielectric and magnetic properties were obtained from dielectric spectroscopy and magnetic hysteresis loops, respectively. The versatility of the films obtained makes them possible candidates for use as biomaterials or electronic device.

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“…On the basis of this behavior, the use of bone cement containing MNPs has been proposed for the hyperthermic treatment of bone tumors [4]. Matsumine et al [5] prepared calcium phosphate cement containing Fe 3 O 4 and conducted clinical trials to treat patients with metastatic bone lesions by hyperthermia, and reported that the patients treated by hyperthermia showed better radiographic outcomes than those treated by palliative operation.…”

Section: Introductionmentioning

confidence: 99%

“…MNFs have huge potential in biomedical applications such as cancer therapy including hyperthermia [6] and tissue regeneration [5]. Visualization of MNFs as well as accurate knowledge about the quantity of MNPs within the MNFs is crucial for effective and safe treatment planning of cancer therapy or tissue regeneration using them [5] [6].…”

Section: Introductionmentioning

confidence: 99%

Visualization of Magnetic Nanofibers Using Magnetic Particle Imaging

Murase

Mimura²,

Banura³

et al. 2015

OJMI

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Purpose: Magnetic nanofibers (MNFs) are nanofibers impregnated with magnetic nanoparticles (MNPs). Magnetic particle imaging (MPI) is a recently introduced imaging method that allows imaging of the spatial distribution of MNPs. The purpose of this study was to develop MNFs and to investigate the feasibility of visualizing them using MPI and of heating them using an alternating magnetic field (AMF). Materials and Methods: First, chitosan nanofibers were cross-linked with glutaraldehyde vapor in a sealed vial for 24 hours. Next, they were mixed with various concentrations of MNPs and the mixture was stirred for 1 hour using a magnetic stirrer. After the mixture was refrigerated at -80˚C for 24 hours, it was freeze-dried for 24 hours. The morphology of the resultant MNFs was characterized by scanning electron microscopy, and the magnetic properties were measured using a vibrating sample magnetometer. After these measurements, we imaged the MNFs using our MPI scanner, and investigated the correlation between the pixel values of the MPI image and the concentration of MNPs or the number of MNF sheets. We also heated the MNFs using AMF, and measured the temperature rise using an infrared thermometer. Results: The MNFs were successfully visualized using our MPI scanner, and the pixel values of the MPI image showed excellent correlation with the concentration of MNPs (r = 0.992) and the number of MNF sheets (r = 0.997). A significant temperature rise was observed under AMF, and the initial slope of the time-dependent temperature rise showed excellent correlation with the concentration of MNPs (r = 0.994) and the number of MNF sheets (r = 0.979). Conclusion: The MNFs developed in this study can be visualized using MPI and can be applied to magnetic hyperthermia. They will be useful in biomedicine including cancer therapy and tissue regeneration.

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Novel hyperthermia for metastatic bone tumors with magnetic materials by generating an alternating electromagnetic field

Cited by 76 publications

References 30 publications

New ferrimagnetic biocomposite film based in collagen and yttrium iron garnet

New ferrimagnetic biocomposite film based in collagen and yttrium iron garnet

Microstructure and magneto-dielectric properties of the chitosan/gelatin-YIG biocomposites

Visualization of Magnetic Nanofibers Using Magnetic Particle Imaging

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