Chinese Journal of Organic Chemistry
 2024
DOI: 10.6023/cjoc202307018
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Novel γ-Carboline Derivatives as Antibacterial Agents: Synthesis and Antibacterial Evaluation

Haibo Huo,
Guixia Li,
Shijun Wang
et al.

Abstract: 其最小抑菌浓度为 8 μg/mL. 探索了化合物 12h 对铜绿假单胞菌的作用机制, 确定了其抑菌机制是通过破坏细菌的 细胞壁发挥抑菌作用. 进一步对该系列衍生物的构效关系进行了讨论, 并总结出若干影响该类化合物生物活性的关键 因素, 为开发新的抗生素提供参考.

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