Novel Immunomodulatory Therapies for Respiratory Pathologies

Tavares, Luciana P.; Galvão, Izabela; Ferrero, Maximiliano Ruben

doi:10.1016/b978-0-12-820472-6.00073-6

Cited by 10 publications

(5 citation statements)

References 481 publications

(569 reference statements)

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“…The presence of protection despite a relatively weak humoral immune response is of interest in the context of the discussion on the consequences of an inadequate immune response during infection, as excessive, inappropriate, or altered immune responses can lead to increased tissue damage, impaired lung function, and worsening of respiratory disease [70].…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Spike Protein-Expressing Enterococcus for Oral Vaccination: Immunogenicity and Protection

Suvorov,

Loginova,

Leontieva

et al. 2023

Vaccines

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The declaration of the conclusion of the COVID-19 pandemic notwithstanding, coronavirus remains prevalent in circulation, and the potential emergence of novel variants of concern introduces the possibility of new outbreaks. Moreover, it is not clear how quickly and to what extent the effectiveness of vaccination will decline as the virus continues to mutate. One possible solution to combat the rapidly mutating coronavirus is the creation of safe vaccine platforms that can be rapidly adapted to deliver new, specific antigens in response to viral mutations. Recombinant probiotic microorganisms that can produce viral antigens by inserting specific viral DNA fragments into their genome show promise as a platform and vector for mucosal vaccine antigen delivery. The authors of this study have developed a convenient and universal technique for inserting the DNA sequences of pathogenic bacteria and viruses into the gene that encodes the pili protein of the probiotic strain E. faecium L3. The paper presents data on the immunogenic properties of two E. faecium L3 vaccine strains, which produce two different fragments of the coronavirus S1 protein, and provides an assessment of the protective efficacy of these oral vaccines against coronavirus infection in Syrian hamsters.

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Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 Spike Protein-Expressing Enterococcus for Oral Vaccination: Immunogenicity and Protection

Suvorov,

Loginova,

Leontieva

et al. 2023

Vaccines

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“…Activation of the lipid-derived molecule leukotriene LTB4 and the consequent production of ROS may contribute to the severity of the inflammatory condition, exacerbating tissue damage and potentially leading to complications such as acute respiratory distress syndrome (ARDS) [ 118 , 119 ]. Furthermore, bronchoconstriction induced by CysLTR1 activation can impair lung function, leading to decreased respiratory capacity and the need for respiratory support [ 120 , 121 ]. Regarding the cytokine imbalance, the increased production of IL-12 and decreased IL-4 suggest that SARS-CoV-2 infection may promote a Th1 immune response associated with inflammation and effector cell activation such as macrophages.…”

Section: Role Of Lipid Droplets In the Viral Infection Cycle And Huma...mentioning

confidence: 99%

Multifaceted Nature of Lipid Droplets in Viral Interactions and Pathogenesis

Herrera-Moro Huitron,

De Jesús-González,

Martínez-Castillo

et al. 2023

Microorganisms

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Once regarded as inert organelles with limited and ill-defined roles, lipid droplets (LDs) have emerged as dynamic entities with multifaceted functions within the cell. Recent research has illuminated their pivotal role as primary energy reservoirs in the form of lipids, capable of being metabolized to meet cellular energy demands. Their high dynamism is underscored by their ability to interact with numerous cellular organelles, notably the endoplasmic reticulum (the site of LD genesis) and mitochondria, which utilize small LDs for energy production. Beyond their contribution to cellular bioenergetics, LDs have been associated with viral infections. Evidence suggests that viruses can co-opt LDs to facilitate their infection cycle. Furthermore, recent discoveries highlight the role of LDs in modulating the host’s immune response. Observations of altered LD levels during viral infections suggest their involvement in disease pathophysiology, potentially through production of proinflammatory mediators using LD lipids as precursors. This review explores these intriguing aspects of LDs, shedding light on their multifaceted nature and implications in viral interactions and disease development.

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“…Эта терапия используется у некоторых пациентов с ХОБЛ и БА. Гетерогенность воспалительных клеток и медиаторов при разных эндофенотипах ХОБЛ и БА требует разработки новых ЛС -антагонистов хемокиновых рецепторов (CXCR2), ингибиторов цитокинов, янус-киназы, селектина, р38 митоген-активированной протеинкиназы и др., которые потенциально могут быть эффективны при АСО с преобладанием фенотипа ХОБЛ или БА с воспалением не-Т2 типа [61].…”

Section: дополнительные лс при Aco опосредованном нет2 воспалениемunclassified

Concomitant bronchial asthma and chronic obstructive pulmonary disease: issues of diagnosis and therapy

Vykhrystsenka

2023

Immunopathol Allergol Infectol

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Novel Immunomodulatory Therapies for Respiratory Pathologies

Cited by 10 publications

References 481 publications

SARS-CoV-2 Spike Protein-Expressing Enterococcus for Oral Vaccination: Immunogenicity and Protection

SARS-CoV-2 Spike Protein-Expressing Enterococcus for Oral Vaccination: Immunogenicity and Protection

Multifaceted Nature of Lipid Droplets in Viral Interactions and Pathogenesis

Concomitant bronchial asthma and chronic obstructive pulmonary disease: issues of diagnosis and therapy

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