Novel indanyl-substituted imidazo[1,2-a]pyridines as potent reversible inhibitors of the gastric H+/K+-ATPase

Tandem Amination/Cycloisomerization of Aryl Propargylic Alcohols with 2‐Aminopyridines as an Expedient Route to Imidazo[1,2‐a]pyridines

“…[9] However, these approaches can suffer from inappropriate substitution patterns, precursors that are difficult to obtain, poor atom economics, and sluggish reactions (up to 10 d). [10] Recently, both we and Gevorgyan et al have independently explored a new approach to imidazo [1,2-a]pyridines by a three-component tandem reaction of 2-aminopyridines, aldehydes, and alkynes. [11] This one-pot reaction is believed to undergo three cascade processes according to path a, namely imination/addition/cycloisomerization (Scheme 1); however, path b, namely addition/amination/cycloisomerization, has not been absolutely excluded.…”

Functionalization of Imidazo[1,2‐a]pyridines by Means of Metal‐Catalyzed Cross‐Coupling Reactions

“…The introduction of carbonyl groups onto imidazo[1,2‐ a ]pyridines at the 6‐position was achieved by palladium‐catalyzed aminocarbonylation 86. A similar method was used by Zimmermann et al57,87 for the synthesis of new biologically active imidazo[1,2‐ a ]pyridines. Mixtures containing 144 , palladium acetate (15 mol‐%), triphenylphosphine, and dimethylamine (2 M solution in tetrahydrofuran) were heated under carbon monoxide (10 bar), directly furnishing N , N ‐dimethylcarboxamide‐substituted imidazo[1,2‐ a ]pyridines 145 and 146 in 76 and 77 % yields, respectively.…”

A Quantitative Structure-Activity Relationship and Molecular Modeling Study on a Series of Biaryl Imidazole Derivatives Acting as H+/K+-ATPase Inhibitors

“…is enzyme is also called proton pump. Since it is unique to parietal cells, it is considered to be a good target for developing the drugs for curing acid-related diseases [2]. e design of proton pump inhibitors (PPIs) is focused on achieving long lasting and rapid inhibition of acid secretion [1].…”