Novel indocyanine green mediated antimicrobial photodynamic therapy in the management of chronic periodontitis - A randomized controlled clinico-microbiological pilot study

Wadhwa, Ananya; Mallapragada, Siddharth; Sharma, Pallavi

doi:10.1016/j.jobcr.2020.11.005

Cited by 8 publications

(28 citation statements)

References 24 publications

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“…Em pacientes com peri-implantite foi observado que, após um dimensionamento da superfície onde é aplicada, ocorre melhores resultados com redução de forma significativa no índice de placa, sangramento sulcular e perda de inserção clínica, ressaltando a importância de estudar os efeitos dos corantes em infecções peri-implantares. Wadhwa et al,2021 Novel indocyanine green mediated antimicrobial photodynamic therapy in the management of chronic periodontitis -a randomized controlled clinico-microbiological pilot study.…”

Section: Discussionunclassified

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Conceitos e aplicabilidade da terapia fotodinâmica na periodontia: revisão de literatura

Pimentel

Dias

2021

RSD

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O Introdução: A Terapia Fotodinâmica é uma reação fotoquímica dependente de oxigênio iniciada por laser de baixa potência com comprimento de onda apropriado. E tem sido amplamente utilizada na periodontia por permitir a redução de periodontopatógenos com ausência de efeitos sistêmicos colaterais e mínimas possibilidades de resistência bacteriana. Objetivo: Realizar uma revisão de literatura sobre a terapia fotodinâmica e a sua importância no tratamento de doenças do periodonto. Metodologia: Foi realizada uma pesquisa bibliográfica nas bases de dados Pubmed, Scielo e Lilacs, com o auxílio dos seguintes descritores em saúde: “Terapia Fotodinâmica” (Photodynamic Therapy); “Fotoquimioterapia” (Photochemotherapy); “Terapia a Laser de Baixa Potência” (Low Powe Laser Therapy) compreendidos entre os anos de 1991 e 2021. Resultados: Atentando para os fatos, viu-se que a escolha de um de um fotossensibilizador e a aplicação com um comprimento de onda correto e específico leva ao sucesso desta terapia. Conclusão: É necessário a realização de mais estudos voltados para a sua utilização no tratamento de doenças periodontais. Sendo definidos protocolos terapêuticos específicos que permitam sua execução baseada na ciência.

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Section: Discussionunclassified

“…Para Wadhwa et al (2021) as perspectivas futuras para TFD são inúmeras, visto que técnicas e estudos têm surgido sobre este advento da odontologia moderna.…”

Section: Discussionunclassified

Conceitos e aplicabilidade da terapia fotodinâmica na periodontia: revisão de literatura

Pimentel

Dias

2021

RSD

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“…Additionally, photonic energy is presumed to enhance tissue healing by bio-stimulatory effects; further improvement of clinical parameters is therefore expected, such as the reduction of PPD and BOP, as well as CAL gain [ 114 ]. Concomitant improvement in clinical and microbiological parameters when aPDT was used as adjunct to SD was reported in several studies [ 115 , 116 , 117 , 118 ]. This was consistent with the results from a current systematic review and meta-analysis that have shown positive effects on the clinical outcomes of using aPDT together with laser, with a high impact on key periodontal pathogens, particularly the red complex [ 119 ].…”

Section: Novel Antibacterial Agents and Strategies To Overcome Bacterial Resistance In Dental Biofilm: Pros And Consmentioning

confidence: 95%

Classic vs. Novel Antibacterial Approaches for Eradicating Dental Biofilm as Adjunct to Periodontal Debridement: An Evidence-Based Overview

et al. 2021

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Periodontitis is a multifactorial chronic inflammatory disease that affects tooth-supporting soft/hard tissues of the dentition. The dental plaque biofilm is considered as a primary etiological factor in susceptible patients; however, other factors contribute to progression, such as diabetes and smoking. Current management utilizes mechanical biofilm removal as the gold standard of treatment. Antibacterial agents might be indicated in certain conditions as an adjunct to this mechanical approach. However, in view of the growing concern about bacterial resistance, alternative approaches have been investigated. Currently, a range of antimicrobial agents and protocols have been used in clinical management, but these remain largely non-validated. This review aimed to evaluate the efficacy of adjunctive antibiotic use in periodontal management and to compare them to recently suggested alternatives. Evidence from in vitro, observational and clinical trial studies suggests efficacy in the use of adjunctive antimicrobials in patients with grade C periodontitis of young age or where the associated risk factors are inconsistent with the amount of bone loss present. Meanwhile, alternative approaches such as photodynamic therapy, bacteriophage therapy and probiotics showed limited supportive evidence, and more studies are warranted to validate their efficiency.

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“…Some of the Ps considered non-toxic and approved for intraoral use are Methylene blue and toluidine blue-O which are approved phenothiazinium salts from the synthetic dyes group that have the most frequent application in dentistry and aPDT ( Asnaashari et al, 2017 ; Okamoto et al, 2020 ; Ramalho et al, 2021 ; Romero et al, 2021 ) Their structural cationic charge facilitates an easy penetration to the gram-negative bacteria’s outer membrane with a high affinity to bacterial cells over body cells ( Gomer, 1991 ). Other PSs that have been considered safe and used to eradicate microorganisms involved in oral and dental diseases are synthetic fluorescent dyes such as the Indocyanine green ( Nikinmaa et al, 2021 ; Wadhwa et al, 2021 ), natural compounds such as Curcumin ( Mendez et al, 2021 ; Moradi et al, 2021 ), nanosized natural zeolite ( Ghazi et al, 2021 ), Riboflavin ( Moradi et al, 2021 ), and Rose Bengal ( Li et al, 2021 ). Various nanoparticle-integrated PSs have also been developed and investigated for their safety and efficacy in clinical applications ( Hendi et al, 2021 ; Shahmoradi et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

“…In recent years several clinical randomized controlled trials have also been designed to evaluate the efficacy of this method in treating oral infectious diseases such as periodontitis ( Wadhwa et al, 2021 ; Arsic et al, 2022 ), periimplantitis ( Shatha-Subhi et al, 2022 ; Shetty et al, 2022 ), halitosis ( Llanos do Vale et al, 2021 ; Romero et al, 2021 ), recurrent herpes labialis ( Ramalho et al, 2021 ), root canal disinfection ( Asnaashari et al, 2017 ; Okamoto et al, 2020 ), oral plaque and caries control ( Nikinmaa et al, 2021 ), and treating fungal diseases caused by candida albicans ( Alves et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Clinical applications of antimicrobial photodynamic therapy in dentistry

et al. 2023

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Given the emergence of resistant bacterial strains and novel microorganisms that globally threaten human life, moving toward new treatment modalities for microbial infections has become a priority more than ever. Antimicrobial photodynamic therapy (aPDT) has been introduced as a promising and non-invasive local and adjuvant treatment in several oral infectious diseases. Its efficacy for elimination of bacterial, fungal, and viral infections and key pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Candida albicans, and Enterococcus faecalis have been investigated by many invitro and clinical studies. Researchers have also investigated methods of increasing the efficacy of such treatment modalities by amazing developments in the production of natural, nano based, and targeted photosensitizers. As clinical studies have an important role in paving the way towards evidence-based applications in oral infection treatment by this method, the current review aimed to provide an overall view of potential clinical applications in this field and summarize the data of available randomized controlled clinical studies conducted on the applications of aPDT in dentistry and investigate its future horizons in the dental practice. Four databases including PubMed (Medline), Web of Science, Scopus and Embase were searched up to September 2022 to retrieve related clinical studies. There are several clinical studies reporting aPDT as an effective adjunctive treatment modality capable of reducing pathogenic bacterial loads in periodontal and peri-implant, and persistent endodontic infections. Clinical evidence also reveals a therapeutic potential for aPDT in prevention and reduction of cariogenic organisms and treatment of infections with fungal or viral origins, however, the number of randomized clinical studies in these groups are much less. Altogether, various photosensitizers have been used and it is still not possible to recommend specific irradiation parameters due to heterogenicity among studies. Reaching effective clinical protocols and parameters of this treatment is difficult and requires further high quality randomized controlled trials focusing on specific PS and irradiation parameters that have shown to have clinical efficacy and are able to reduce pathogenic bacterial loads with sufficient follow-up periods.

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Novel indocyanine green mediated antimicrobial photodynamic therapy in the management of chronic periodontitis - A randomized controlled clinico-microbiological pilot study

Cited by 8 publications

References 24 publications

Conceitos e aplicabilidade da terapia fotodinâmica na periodontia: revisão de literatura

Conceitos e aplicabilidade da terapia fotodinâmica na periodontia: revisão de literatura

Classic vs. Novel Antibacterial Approaches for Eradicating Dental Biofilm as Adjunct to Periodontal Debridement: An Evidence-Based Overview

Clinical applications of antimicrobial photodynamic therapy in dentistry

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