Novel inflammatory biomarkers may reflect subclinical inflammation in young healthy adults with obesity

Abstract

Introduction: Obesity is often accompanied by low-grade inflammation. In recent years a few blood-based inflammatory markers-neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), lymphocyteto-monocyte ratio (LMR), and monocyte-to-high-density lipoprotein ratio (MHR)-have been identified. They have been proven to correlate well with established inflammatory markers such as hsCRP and have a prognostic value among others in patients with coronary artery disease, heart failure, and malignancies. The aim of the study was to find markers associated with obesity in young heathy adults. Material and methods: The study group included 321 young healthy adults aged 18-35 years (210 males and 111 females). Partial least squares regression analysis was used to find variables associated with body mass index (BMI). Analysed variables included complete blood count, lipid profile, sex hormone levels, acute-phase protein levels, and blood-based inflammatory markers. Results: Variables with the strongest association with BMI in the group of men were HDL% and apolipoprotein B, and in the group of women, HDL, HDL%, triglycerides, and MHR. Novel inflammatory markers were not associated with BMI, except MHR. We found significant (p < 0.001) correlations between novel biomarkers (NLR, dNLR) and hsCRP and fibrinogen levels in the group of subjects with obesity. Conclusions: Blood-based inflammatory markers significantly correlate with hsCRP and fibrinogen in young healthy adults with obesity, which may reflect the subclinical inflammation in this group of individuals.

The impact of asthma, toll-like receptors 7 and 8, genetic and clinical determinants on antiviral immune response

“…The common denominator between high BMI, oxidative stress and vitamin availability is, of course, diet. Obesity is associated with systemic inflammation and oxidative stress and one explanation is poor diet (Manna & Jain 2015;Osadnik et al 2019). Meta-analyses show that vitamin D supplementation, antioxidant flavonoid intake and probiotics decrease the incidence of respiratory infections, which supports our findings that vitamin availability and oxidative stress affect antiviral immunity (Martineau et al 2017;Quick 2015;Somerville, Braakhuis & Hopkins 2016).…”

Inflammation may be correlated with Symptomatic Neurosyphilis

“…Recently, hemogram is the most commonly, rapidly and widely available laboratory method, hence, it has been reported that NLR and PLR represent a novel composite inflammatory marker. They have been proven to correlate with CRP, as well as they have a prognostic value among patients with cancer, coronary artery disease, and some CNS diseases, such as traumatic brain injury, intracranial hemorrhage, and cerebral venous thorombosis [19][20][21][22][23], However, to be best of our knowledge, there was no study between NS and NLR. As clinically easily available biomarkers, CRP and NLR in the peripheral blood were used in our study to represent the inflammatory response.…”

Comparison of Laboratory Features of Symptomatic and Asymptomatic Neurosyphilis

“…Recently, Because of serum hemogram is cheap and easy, and it is the most commonly, rapidly and widely available laboratory method, hence, it has been reported that NLR and PLR represents a novel composite inflammatory marker, and they have been proven to correlate with CRP, as well as they have a prognostic value among patients with cancer, coronary artery disease, and some CNS diseases, such as traumatic brain injury, intracranial hemorrhage, and cerebral venous thorombosis [12][13][14][15][16][17][18], However, to be best of our knowledge, there was no study between NS and NLR. In this study, we analyzed the NLR in 111 NS patients and found that different clinical types of NS might present with different levels of NLR.…”