Novel insight into the distribution and dissemination of <i>Candidatus</i> Liberibacter asiaticus, the causal agent of citrus Huanglongbing

QingLian, Wang; Xu, Yunlong; Yang, X. B.; Jin, Jia Yi; Zhou, Jiale; Zeng, Jiwu; Xiang, Yan; Li, Jinxue; Jian-qiang, Yue; Guo, Jun; Yang, Yi; ChangXiu, Xia; Hóng, Ní; Wang, Guoping; Peng, Shuang; Duan, Yongping; Hartung, John; Ding, Fang

doi:10.1111/pbi.13753

Cited by 9 publications

(1 citation statement)

References 6 publications

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“…Mandarin production is forecast to decrease to 26.5 million metric tons in 2023 due to unfavorable weather and reduced planted acreage resulting from Huanglongbing (HLB). HLB is the most destructive disease of citrus and has caused large losses in citrus cultivation worldwide, covering more than 50 nations in the tropics and subtropics of Asia and Africa, including India and Bangladesh. − In China, the disease is caused by infection by the unculturable α-proteobacterium Candidatus Liberibacter asiaticus ( Ca Las). There are significant differences in susceptibility to HLB among the main citrus species, and the degree of susceptibility is generally in the order of loose-skin mandarin > sweet orange > pomelo.…”

Section: Introductionmentioning

confidence: 99%

Screening Universal Stress-Response Terpenoids and Their Biosynthetic Genes via Volatile and Transcriptomic Profiling in Citrus

Wen,

Zhang,

Liu

et al. 2023

J. Agric. Food Chem.

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Volatile terpenoids accumulate in citrus and play important roles in plant defense against various stressors. However, the broad-spectrum response of terpenoid biosynthesis to ubiquitous stressors in citrus has not been comparatively investigated. In this study, volatile terpenoids were profiled under six stressors: high temperature, citrus miner, citrus red mite, citrus canker, Alternaria brown spot, and huanglongbing (HLB). Significant content changes in 15 terpenoids, including β-ocimene, were observed in more than four of the six stressors, implying their possibly universal stress-response effects. Notably, the emission of terpenoids, including β-caryophyllene, β-ocimene, and nerolidol glucoside, was significantly increased by HLB in HLB-tolerant "Shatian" pomelo leaves. The upregulation of CgTPS1 and CgTPS2 and their characterization in vivo identified them as mono-or sesquiterpenoid biosynthetic genes. This study provides a foundation for determining stress resistance mechanisms in citrus and biopesticide designations for future industrial applications.

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Section: Introductionmentioning

confidence: 99%

Screening Universal Stress-Response Terpenoids and Their Biosynthetic Genes via Volatile and Transcriptomic Profiling in Citrus

Wen,

Zhang,

Liu

et al. 2023

J. Agric. Food Chem.

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Engineering Extracellular Vesicles as Delivery Systems in Therapeutic Applications

Wang

et al. 2023

Advanced Science

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Extracellular vesicles (EVs) are transport vesicles secreted by living cells and released into the extracellular environment. Recent studies have shown that EVs serve as "messengers" in intercellular and inter-organismal communication, in both normal and pathological processes. EVs, as natural nanocarriers, can deliver bioactivators in therapy with their endogenous transport properties. This review article describes the engineering EVs of sources, isolation method, cargo loading, boosting approach, and adjustable targeting of EVs. Furthermore, the review summarizes the recent progress made in EV-based delivery systems applications, including cancer, cardiovascular diseases, liver, kidney, nervous system diseases, and COVID-19 and emphasizes the obstacles and challenges of EV-based therapies and possible strategies.

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Transforming native exosomes to engineered drug vehicles: A smart solution to modern cancer theranostics

Sahoo,

Tripathi,

Biswal

et al. 2024

Biotechnology Journal

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Exosomes have been the hidden treasure of the cell in terms of cellular interactions, transportation and therapy. The native exosomes (NEx) secreted by the parent cells hold promising aspects in cancer diagnosis and therapy. NEx has low immunogenicity, high biocompatibility, low toxicity and high stability which enables them to be an ideal prognostic biomarker in cancer diagnosis. However, due to heterogeneity, NEx lacks specificity and accuracy to be used as therapeutic drug delivery vehicle in cancer therapy. Transforming these NEx with their innate structure and multiple receptors to engineered exosomes (EEx) can provide better opportunities in the field of cancer theranostics. The surface of the NEx exhibits numeric receptors which can be modified to pave the direction of its therapeutic drug delivery in cancer therapy. Through surface membrane, EEx can be modified with increased drug loading potentiality and higher target specificity to act as a therapeutic nanocarrier for drug delivery. This review provides insights into promising aspects of NEx as a prognostic biomarker and drug delivery tool along with its need for the transformation to EEx in cancer theranostics. We have also highlighted different methods associated with NEx transformations, their nano‐bio interaction with recipient cells and major challenges of EEx for clinical application in cancer theranostics.

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Novel insight into the distribution and dissemination of Candidatus Liberibacter asiaticus, the causal agent of citrus Huanglongbing

Cited by 9 publications

References 6 publications

Screening Universal Stress-Response Terpenoids and Their Biosynthetic Genes via Volatile and Transcriptomic Profiling in Citrus

Screening Universal Stress-Response Terpenoids and Their Biosynthetic Genes via Volatile and Transcriptomic Profiling in Citrus

Engineering Extracellular Vesicles as Delivery Systems in Therapeutic Applications

Transforming native exosomes to engineered drug vehicles: A smart solution to modern cancer theranostics

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