Novel insight into the liver-lung axis in alcohol-enhanced acute lung injury.

Abstract

for his expertise in acute lung injury, and Drs. Leah Siskind and Christopher States for their expertise in mechanistic toxicology. I would also like to thank the Roman group, especially Dr. Edilson Torres-Gonzáles for his training in surgical techniques and Jeffrey Ritzenthaler for his technical guidance, as well as Connie Schleuter in the Hoyle group for her assistance with pulmonary function measurements. Thank you to Dr. Jill Steinbach and her laboratory for providing not only the tamoxifen-loaded PLGA nanoparticles used in these studies, but also for their expertise with the guidance provided for working with these particles. Finally, the in-vivo studies presented in this dissertation would not have been possible without the constant guidance and assistance from Dr. Juliane Beier. Many thanks to all my lab mates, past and present: To Dr. Veronica Massey and Jenny Jokinen for investing countless valuable hours in my training as an undergraduate and beyond and to Dr. Deanna Davis for teaching me to be confident in my scientific intuition. I must also thank Calvin Nguyen-Ho for running endless v genotyping gels and qRT-PCR plates, as well as Christine Dolin, Shanice Hudson, Anna Lang, and Jamie Young for their support, experimentally and otherwise. I must thank my friends and family who have always supported and encouraged me, even when the demands of this dissertation drove me to be totally antisocial and insufferable-Veronica Massey, Tess Dupre, Michael Ringlein, Nikole Warner, and Gretchen Holz, among so many others. Finally, to my family-my mother, Janet Weiss, my father, Michael Poole, my sister, Meghan Poole, and my husband, David Hardy-you are what drives me to seek my highest potential. Last, but most certainly not least, I thank the faculty and staff of the Department of Pharmacology and Toxicology for providing the constant guidance and perfect environment for my growth as an independent scientist.