Novel Insight of CircRNAs in Cervical Cancer: Potential Biomarkers and Therapeutic Target

Wu, Maomao; Han, Yanxun; Gong, X. G.; Wan, Ke; Liu, Yuchen; Zhou, Yi; Zhang, Lizhi; Tang, Guozheng; Fang, Hui; Chen, Bangjie; Yang, Fan; Zhao, Qing; Wang, Genbao; Zhanghuang, Chenghao; Zhang, Yunling

doi:10.3389/fmed.2022.759928

Cited by 7 publications

(2 citation statements)

References 83 publications

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“…Transcriptome analyses in CC have identified changes in the expression of genes involved in cell transformation and immune response. Moreover, other RNAs involved in the disease have been identified, such as miRNAs, circRNAs, and long ncRNAs, that play essential roles in cancer pathogenesis as tumor promoters or suppressors ( 73 – 75 ). Salmerón-Bárcenas et al.…”

Section: New Advances In Molecular Characterization Of Cervical Cancermentioning

confidence: 99%

Molecular aspects of cervical cancer: a pathogenesis update

Vallejo-Ruiz,

Gutiérrez-Xicotencatl,

Medina-Contreras

et al. 2024

Front. Oncol.

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Cervical cancer (CC) is a significant health problem, especially in low-income countries. Functional studies on the human papillomavirus have generated essential advances in the knowledge of CC. However, many unanswered questions remain. This mini-review discusses the latest results on CC pathogenesis, HPV oncogenesis, and molecular changes identified through next-generation technologies. Interestingly, the percentage of samples with HPV genome integrations correlates with the degree of the cervical lesions, suggesting a role in the development of CC. Also, new functions have been described for the viral oncoproteins E5, E6, and E7, resulting in the acquisition and maintenance of cancer hallmarks, including proliferation, immune response evasion, apoptosis, and genomic instability. Remarkably, E5 oncoprotein affects signaling pathways involved in the expression of interferon-induced genes and EGFR-induced proliferation, while E6 and E7 oncoproteins regulate the DNA damage repair and cell cycle continuity pathways. Furthermore, next-generation technologies provide vast amounts of information, increasing our knowledge of changes in the genome, transcriptome, proteome, metabolome, and epigenome in CC. These studies have identified novel molecular traits associated with disease susceptibility, degree of progression, treatment response, and survival as potential biomarkers and therapeutic targets.

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Section: New Advances In Molecular Characterization Of Cervical Cancermentioning

confidence: 99%

Molecular aspects of cervical cancer: a pathogenesis update

Vallejo-Ruiz,

Gutiérrez-Xicotencatl,

Medina-Contreras

et al. 2024

Front. Oncol.

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“…Tang et al . noticed that patients with squamous CC and low serum circFoxO3a levels had a poorer prognosis [ 178 , 183 ]. On the other hand, the overexpression of circEIF4G2 was found to be linked to tumor size and lymph node metastasis.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Circular RNAs and cervical cancer: friends or foes? A landscape on circRNA-mediated regulation of key signaling pathways involved in the onset and progression of HPV-related cervical neoplasms

Heydarnia,

Dorostgou,

Hedayati

et al. 2024

Cell Commun Signal

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Cervical cancer (CC) is a common gynecologic malignancy, accounting for a significant proportion of women death worldwide. Human papillomavirus (HPV) infection is one of the major etiological causes leading to CC onset; however, genetic, and epigenetic factors are also responsible for disease expansion. Circular RNAs (circRNAs), which are known as a particular subset of non-coding RNA (ncRNA) superfamily, with covalently closed loop structures, have been reported to be involved in the progression of diverse diseases, especially neoplasms. In this framework, abnormally expressed circRNAs are in strong correlation with CC pathogenesis through regulating substantial signaling pathways. Also, these RNA molecules can be considered as promising biomarkers and therapeutic targets for CC diagnosis/prognosis and treatment, respectively. Herein, we first review key molecular mechanisms, including Wnt/β-catenin, MAPK, and PI3K/Akt/mTOR signaling pathways, as well as angiogenesis and metastasis, by which circRNAs interfere with CC development. Then, diagnostic, prognostic, and therapeutic potentials of these ncRNA molecules will be highlighted in depth.

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Hsa_circ_0000069 Accelerates Cervical Cancer Progression by Sponging miR-1270 to Facilitate CPEB4 Expression

Gong,

Ge,

et al. 2023

Biochem Genet

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Novel Insight of CircRNAs in Cervical Cancer: Potential Biomarkers and Therapeutic Target

Cited by 7 publications

References 83 publications

Molecular aspects of cervical cancer: a pathogenesis update

Molecular aspects of cervical cancer: a pathogenesis update

Circular RNAs and cervical cancer: friends or foes? A landscape on circRNA-mediated regulation of key signaling pathways involved in the onset and progression of HPV-related cervical neoplasms

Hsa_circ_0000069 Accelerates Cervical Cancer Progression by Sponging miR-1270 to Facilitate CPEB4 Expression

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