Novel Insights and Current Evidence for Mechanisms of Atherosclerosis: Mitochondrial Dynamics as a Potential Therapeutic Target

Li, Dan; Yang, Shengjie; Xing, Yanwei; Pan, Limin; Zhao, Ran; Zhao, Yang; Liu, Longtao; Wu, Min

doi:10.3389/fcell.2021.673839

Cited by 34 publications

(28 citation statements)

References 198 publications

(210 reference statements)

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“…More importantly, the elimination of the so-called junk foods that are high in trans fatty acids (TFA), TG, LDL, and low in HDL can significantly improve patients' lipid profiles. On the other hand, an increased level of TFA additionally increases the amount of pro-inflammatory cytokines, causing endothelial dysfunction and insulin resistance [78]. Artificial TFAs are associated with an increased risk of atherosclerosis and cardiovascular events [79].…”

Section: Atherosclerosis and The Action Of Lycopenementioning

confidence: 99%

Lycopene in the Prevention of Cardiovascular Diseases

Przybylska

Tokarczyk

2022

IJMS

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Cardiovascular diseases (CVDs) are the leading cause of human mortality worldwide. Oxidative stress and inflammation are pathophysiological processes involved in the development of CVD. That is why bioactive food ingredients, including lycopene, are so important in their prevention, which seems to be a compound increasingly promoted in the diet of people with cardiovascular problems. Lycopene present in tomatoes and tomato products is responsible not only for their red color but also for health-promoting properties. It is characterized by a high antioxidant potential, the highest among carotenoid pigments. Mainly for this reason, epidemiological studies show a number of favorable properties between the consumption of lycopene in the diet and a reduced risk of cardiovascular disease. While there is also some controversy in research into its protective effects on the cardiovascular system, growing evidence supports its beneficial role for the heart, endothelium, blood vessels, and health. The mechanisms of action of lycopene are now being discovered and may explain some of the contradictions observed in the literature. This review aims to present the current knowledge in recent years on the preventive role of lycopene cardiovascular disorders.

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Section: Atherosclerosis and The Action Of Lycopenementioning

confidence: 99%

Lycopene in the Prevention of Cardiovascular Diseases

Przybylska

Tokarczyk

2022

IJMS

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“…Mitochondrial shape affects the ability of cells to distribute their mitochondria to specific subcellular locations. Fusion and fission allow the mitochondrial exchange of lipid membranes and intramitochondrial content, which is crucial for maintaining the health of a mitochondrial population ( 51 ). For instance, MFN1 and MFN2 ablation in fibroblasts induce reduced respiratory capacity and great heterogeneity in mitochondrial shape and membrane potential ( 52 ).…”

Section: Regulation Of Mitochondrial Dynamicsmentioning

confidence: 99%

Mitochondrial Dynamics: Pathogenesis and Therapeutic Targets of Vascular Diseases

Luan

Ren

Luan

et al. 2021

Front. Cardiovasc. Med.

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Vascular diseases, particularly atherosclerosis, are associated with high morbidity and mortality. Endothelial cell (EC) or vascular smooth muscle cell (VSMC) dysfunction leads to blood vessel abnormalities, which cause a series of vascular diseases. The mitochondria are the core sites of cell energy metabolism and function in blood vessel development and vascular disease pathogenesis. Mitochondrial dynamics, including fusion and fission, affect a variety of physiological or pathological processes. Multiple studies have confirmed the influence of mitochondrial dynamics on vascular diseases. This review discusses the regulatory mechanisms of mitochondrial dynamics, the key proteins that mediate mitochondrial fusion and fission, and their potential effects on ECs and VSMCs. We demonstrated the possibility of mitochondrial dynamics as a potential target for the treatment of vascular diseases.

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“…In recent years, a growing number of studies have shown that atherosclerosis may be related to mitochondrial fusion and fission. 64 In recent years, a growing number of studies have shown that atherosclerosis may be related to mitochondrial fusion and fission. 64 During the early stages of atherosclerosis, increased ROS levels induce endothelial dysfunction, vascular inflammation, and accelerated accumulation of oxidized low-density lipoprotein (ox-LDL) in the arterial wall.…”

Section: Role Of Mitochondrial Dysfunctionmentioning

confidence: 99%

“…64 In recent years, a growing number of studies have shown that atherosclerosis may be related to mitochondrial fusion and fission. 64 During the early stages of atherosclerosis, increased ROS levels induce endothelial dysfunction, vascular inflammation, and accelerated accumulation of oxidized low-density lipoprotein (ox-LDL) in the arterial wall. Excessive LDL deposition can induce apoptosis of vascular cells through a dependent mitochondrial pathway after oxidative modification.…”

Section: Role Of Mitochondrial Dysfunctionmentioning

confidence: 99%

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Subclinical Vascular Damage: Current Insights and Future Potential

Mattioli¹,

Coppi²,

Manenti³

et al. 2021

VHRM

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The cardiovascular risk assessment must be carried out during all the different phases of life because the cardiovascular risk and the related prevention actions are dynamic and constantly evolving. As patients age, they change their exposure to various risk factors and accumulate comorbidities by changing their subjective cardiovascular risk, so it is necessary to undertake personalized early and preventive diagnostic actions. The main approach to asymptomatic vascular disease is based on primary prevention with the adoption of a healthy lifestyle. Indeed, lifestyle influences most of the traditional risk factors. In recent years, important differences between the sexes regarding cardiovascular risk factors have emerged and in particular, risk factors specific for female sex have been identified. Women are more likely to be categorized into lower risk categories for cardiovascular disease and, as a result, receive less lifestyle counseling than men, as well as less intensive prevention. This narrative review aims to analyze CVD risk prevention in asymptomatic atherosclerosis with a look at new emerging factors. In the end, we quickly analyzed the effects of the recent pandemic on lifestyle and cardiovascular risk and the potential negative effects in the long term.

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Novel Insights and Current Evidence for Mechanisms of Atherosclerosis: Mitochondrial Dynamics as a Potential Therapeutic Target

Cited by 34 publications

References 198 publications

Lycopene in the Prevention of Cardiovascular Diseases

Lycopene in the Prevention of Cardiovascular Diseases

Mitochondrial Dynamics: Pathogenesis and Therapeutic Targets of Vascular Diseases

Subclinical Vascular Damage: Current Insights and Future Potential

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