Novel Insights in Fetal Cardiomyopathy due to in utero Herpes Simplex Virus Infection

Pahlitzsch, Tamara Margit Jutta; Helbig, Elisa T; Sarioglu, N.; Hinkson, Larry; Weizsäcker, Katharina; Henrich, Wolfgang

doi:10.1159/000475814

Cited by 2 publications

(1 citation statement)

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“…Неясна роль других ГВ при ВУИ: вируса Эпштейна-Барр (ВЭБ), вирусов герпеса человека 6 и 7 типов (ВГЧ-6, -7) -мало изучена их распространенность у беременных, детей разного возраста, их клиническое значение, не разработаны рекомендации по ведению ВЭБ-инфекции (за исключением инфекционного мононуклеоза) и ВГЧ-6-инфекции (ВГЧИ-6). ВЭБИ у новорожденных может приводить к поражению различных органов и патологической иммуносупрессии [10]. ВГЧИ-6 сопровождается неспецифичными симптомами, но в даль-нейшем при воздействии неблагоприятных факторов возможна ее реактивация с развитием внезапной экзантемы, лихорадки неясного генеза, синдрома хронической усталости, иммунной нейтропении, также была выявлена взаимосвязь между ВГЧ-6 и рассеянным склерозом [11,12].…”

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The role of opportunistic pathogens as etiological agents of intrauterine infections

et al. 2019

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The study showed a high prevalence of markers of herpesvirus infections among mothers — from 71% to 98% of HSV, EBV and CMV infections and from 29% to 58% of HHV-6 infection. HSV remains the most common etiological agent of intrauterine infections among herpesviruses — markers of active infection caused by this virus were found in 28.3% samples. The difficulty of determining the source of infection in the absence of data in the early stages of pregnancy is presented on 4 out of 10 cases of active HHV-6 infection. Markers of active pneumocystic infection were detected only in mothers: in the group with children under the age of 21 days — in 21—27% of cases, with children aged 22 to 28 days — in 15—21%. In addition to non-specific multiple organ failure during intrauterine infections (26.3%), only one organ system was observed: hypoxic-hemorrhagic lesions of the central nervous system were diagnosed more often — 17%, as well as meningitis/encephalitis, or hepatitis, or pneumonia, or disorders of hematopoiesis, or rash. In 17.5% of children from the comparison group, i.e. without any clinical manifestations of intrauterine infections, markers of active herpes virus infections were detected.

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The role of opportunistic pathogens as etiological agents of intrauterine infections

et al. 2019

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Fetal and neonatal abnormalities due to congenital herpes simplex virus infection: a literature review

Laup

Mandelbrot

et al. 2020

Prenatal Diagnosis

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Objective Herpes simplex virus (HSV) infection during pregnancy can cause severe neonatal infections. It is also a rare cause of congenital infections. We aimed to describe fetal and neonatal abnormalities of congenital HSV infection in order to define the features that are accessible to prenatal diagnosis during ultrasound screening and/or during a work‐up for congenital malformations. Methods We analysed all cases of congenital HSV infection (CHI) described before and/or after birth and identified in Pubed and classified the findings as accessible or not to prenatal diagnosis. Results Thirty‐six cases of congenital herpes infection were reported, of which 15 were described prenatally and 21 postnatally. The most frequently reported malformations accessible to prenatal diagnosis were cerebral anomalies. The most common abnormalities described after birth were skin lesions and keratitis, which are not considered amenable to prenatal ultrasound detection. CHI can due to either HSV1 or HSV2 infection, whether primary or non‐primary infection, with or without the presence of maternal symptoms. Conclusion Prenatal ultrasound abnormalities due to CHI are rare, varied and non‐specific. There is no clear role for fetal ultrasound in the routine management of women with primary or non‐primary HSV infection in pregnancy. However, in fetuses with ultrasound abnormalities suggestive of congenital infection, HSV should still be considered as a differential diagnosis after the more common in utero infections, such as cytomegalovirus, are excluded.

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Novel Insights in Fetal Cardiomyopathy due to in utero Herpes Simplex Virus Infection

Cited by 2 publications

References 20 publications

The role of opportunistic pathogens as etiological agents of intrauterine infections

The role of opportunistic pathogens as etiological agents of intrauterine infections

Fetal and neonatal abnormalities due to congenital herpes simplex virus infection: a literature review

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