This chapter presents a comprehensive overview of nutrient management practices tailored for optimizing maize production. It covers critical aspects, including soil testing protocols, advanced fertilizer application methods, organic and inorganic amendments, precision nutrient management approaches, integrated strategies, and conservation agriculture-based practices. Recognizing maize’s significance for global food security and economic prosperity, the chapter emphasizes efficient and sustainable nutrient management to achieve high yields. Precision technologies enable targeted fertilizer applications, while organic and inorganic amendments enhance soil fertility and nutrient cycling. Integrated nutrient management reduces environmental risks and improves long-term soil fertility. Conservation agriculture-based practices, such as reduced tillage and cover cropping, positively influence maize yield and sustainability by enhancing nutrient retention and water management. Overall, adopting appropriate nutrient management practices is crucial for maximizing maize production while ensuring food security and environmental well-being.