Novel insights into fecal incontinence in men

Mazor, Yoav; Jones, Michael; Andrews, Alison; Kellow, John; Malcolm, Allison

doi:10.1152/ajpgi.00362.2016

Cited by 10 publications

(15 citation statements)

References 41 publications

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“…In this work, the etiological profile of refractory FI in men was different from that in women, including predominantly anal surgery and LARS. These data are, in part, comparable with those reported in the literature . The factors leading to FI in men are generally less well‐studied than those in women.…”

Section: Discussionsupporting

confidence: 87%

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Is Sacral Nerve Modulation a Good Option for Fecal Incontinence in Men?

Brochard

Mège

Bridoux

et al. 2019

Neuromodulation: Technology at the Neural Interface

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Section: Discussionsupporting

confidence: 87%

“…One might ask if this proportion is well‐representative of the proportion of men with FI. In the unit of Rennes, 11.1% of referred FI patients were men and were of similar age to women, which is in‐line with previous publications . It is thus interesting to consider why fewer men seek consultation for FI.…”

Section: Discussionsupporting

confidence: 82%

Is Sacral Nerve Modulation a Good Option for Fecal Incontinence in Men?

Brochard

Mège

Bridoux

et al. 2019

Neuromodulation: Technology at the Neural Interface

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“…The causes of RI are multifactorial, but a leading cause in humans is an aging-associated decrease in the IAS tone (AADI) and compromise in the fibroelastic properties (FEP) of the IAS 5–7 . Little is known about the molecular mechanisms underlying these phenomena, and this has impeded the development of a specific and safe treatment for debilitating AADI-related RI 5,8 .…”

Section: Introductionmentioning

confidence: 99%

Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone

Mohanty

Singh

Rattan

2019

Sci Rep

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Aging-associated decrease in internal anal sphincter (IAS) tone (AADI) is a major contributor in the rectoanal incontinence (RI). To determine the pathogenesis of AADI, we investigated the effect of aging on GPCR activation and related downstream signaling. We particularly investigated two GPCRs that characterize IAS smooth muscle cells (SMCs): thromboxane A 2 and angiotensin II type 1. Two groups of Fischer 344 rats (6-month-old [young group] and 26-month-old [old group]) were employed to determine the GPCR function by isometric contraction, the expressions of GPCRs, and their downstream regulatory signaling proteins (regulator of G-protein signaling 2, RGS2; GPCR Kinase 5, GRK5; and β-arrestin, Arrb2) using RT-PCR, qPCR, and western blot analyses. We used reversible biotinylation to monitor the GPCR trafficking using SMCs. Aging selectively attenuated thromboxane A 2 and Ang II-induced IAS contraction. RT-PCR, qPCR, and WB data revealed a significant decrease in the expressions of the GPCRs and increase in the expression of RGS2, GRK5, and Arrb2. The increased GPCR internalization and decreased recycling under aging were validated by reversible biotinylation. We conclude that downregulation of GPCR, accompanied by upregulation of regulatory proteins, plays an important role in receptor desensitization and may be important underlying mechanisms of RI in certain aging patients.

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“…However, because anorectal pressures during evacuation overlap between DD and healthy subjects, further studies are necessary to understand the relative contribution of manometric findings to the pathophysiology of DD 6 . ARM is also useful for identifying anal weakness and rectal sensory disturbances in fecal incontinence (FI), 7,8 and for assessing reflex relaxation of the IAS in response to rectal distension in patients being tested for Hirschsprung disease, as well as those with megarectum or megacolon 9,10 …”

Section: Introductionmentioning

confidence: 99%

Review of the indications, methods, and clinical utility of anorectal manometry and the rectal balloon expulsion test

Bharucha

Basilisco

Malcolm

et al. 2022

Neurogastroenterology Motil

Self Cite

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Anorectal manometry (ARM) is a sophisticated technique that quantifies several aspects of the complex and multifactorial mechanisms that regulate defecation and continence. 1 ARM records contractility and tone of the internal (IAS) and external anal sphincters (EAS); rectal sensitivity and compliance; the reflex relaxation of the IAS in response to rectal distension; the reflex contraction of the EAS in response to cough or Valsalva maneuver; and the dynamic changes of rectal and anal pressures during simulated evacuation. The technological advances of ARM and other techniques that assess colonic and anorectal functions (e.g., high-resolution colonic manometry and magnetic resonance imaging [MRI] proctography) have enhanced our understanding of the physiology of defecation and continence and related disorders. Anorectal manometry and the rectal balloon expulsion test are recommended initial tests for diagnosing DD in patients who have

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Novel insights into fecal incontinence in men

Cited by 10 publications

References 41 publications

Is Sacral Nerve Modulation a Good Option for Fecal Incontinence in Men?

Is Sacral Nerve Modulation a Good Option for Fecal Incontinence in Men?

Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone

Review of the indications, methods, and clinical utility of anorectal manometry and the rectal balloon expulsion test

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