Novel insights into the effects of levodopa on the up- and downstrokes of writing sequences

Broeder, Sanne; Boccuni, Leonardo; Vandendoorent, Britt; Verheyden, Geert; Meesen, Raf; Nieuwboer, Alice

doi:10.1007/s00702-022-02493-6

Cited by 1 publication

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 C). The task was sensitive to medication effects [ 24 ] and required producing a figure-8 pattern with increasing amplitudes [ 25 ]. Subjects were instructed to reproduce the targeted writing size at a comfortable speed for 45 s. A rest period (10 s) was applied in-between each trial.…”

Section: Methodsmentioning

confidence: 99%

Transcranial direct current stimulation enhances motor learning in Parkinson’s disease: a randomized controlled trial

et al. 2023

Self Cite

View full text Add to dashboard Cite

Writing training has shown clinical benefits in Parkinson’s disease (PD), albeit with limited retention and insufficient transfer effects. It is still unknown whether anodal transcranial direct current stimulation (atDCS) can boost consolidation in PD and how this interacts with medication. To investigate the effects of training + atDCS versus training + sham stimulation on consolidation of writing skills when ON and OFF medication. Second, to examine the intervention effects on cortical excitability. In this randomized sham-controlled double-blind study, patients underwent writing training (one session) with atDCS ( N = 20) or sham ( N = 19) over the primary motor cortex. Training was aimed at optimizing amplitude and assessed during online practice, pre- and post-training, after 24-h retention and after continued learning (second session) when ON and OFF medication (interspersed by 2 months). The primary outcome was writing amplitude at retention. Cortical excitability and inhibition were assessed pre- and post-training. Training + atDCS but not training + sham improved writing amplitudes at retention in the ON state ( p = 0.017, g = 0.75). Transfer to other writing tasks was enhanced by atDCS in both medication states ( g between 0.72 and 0.87). Also, training + atDCS improved continued learning. However, no online effects were found during practice and when writing with a dual task. A post-training increase in cortical inhibition was found in the training + atDCS group ( p = 0.039) but not in the sham group, irrespective of medication. We showed that applying atDCS during writing training boosted most but not all consolidation outcomes in PD. We speculate that atDCS together with medication modulates motor learning consolidation via inhibitory processes ( https://osf.io/gk5q8/ , 2018-07-17). Supplementary Information The online version contains supplementary material available at 10.1007/s00415-023-11669-3.

show abstract

Section: Methodsmentioning

confidence: 99%