Novel Insights into the Inhibitory Effect and Mechanism of Proanthocyanidins from Pyracantha fortuneana Fruit on α‐Glucosidase

Abstract

In this study, Pyracantha fortuneana fruit proanthocyanidins with a yield of 3.05% were identified for the first time as predominantly constituted of procyanidin with A-type and B-type linkage and coexistence of procyanidins glucoside. Proanthocyanidins from P. fortuneana fruit had higher anti-α-glucosidase activity value compared with positive control acarbose, which indicated that P. fortuneana fruit proanthocyanidins with a possibility to be used as novel natural antidiabetic agents in functional food industries.

Effects of different drying methods on the physicochemical property and edible quality of fermented Pyracantha fortuneana fruit powder

“…Li, a wild evergreen shrub or small arbour belonging to the Pyracantha of Osaceae apple subfamily, is mainly distributed in areas from eastern Asia to southern Europe. Pyracantha fortuneana fruit (PFF), as a new food resource, has become a research hotspot due to its rich nutrients and natural active ingredients, and it is even treated as a staple food in some areas in case of food shortage (Wei et al ., 2017; Wang et al ., 2019). However, most PFF are wild fruits, with several disadvantages for eating, such as small fruit size, rough and astringent taste, fresh fruit seasonality and intolerance to storage.…”

Review of traditionally consumed antidiabetic fruits in the diet

“…Pyracantha fortuneana fruit (PFF) is a fruit which is rich in proanthocyanin. The results of the research indicated that PFF inhibited αglucosidase in a non-competitive type with the IC 50 value of 0.15 μg/ml (Wei et al, 2017). The study also demonstrated the inhibitory mechanism of proanthocyanins on α-glucosidase.…”

“…For instance Sarcopoterium spinosum, Japanese apricot, Ficus deltoidea, Passiflora ligularis, Persea Americana, Rosa canina, Vaccinium myrtillus, Terminalia catappa L., Myristica fragrans, Pimenta dioica, Momordica charantia, Sarcopoterium spinosum, Mango, Pyracantha fortuneana, Chrysophyllum cainito L., Pometia pinnata, Malus communis L., Empetrum nigrum L., Momordica charantia, Zizyphus lotus, Xylopia aethiopica, Morinda Citrifolia L., Malus communis L., Coriandrum sativum L., Juglans regia L., Sorbus umbellate, Fritsch var. Cretica, Schneider and encapsulated Citrus limon Osbeck were reported for their inhibitory activity on α-amylase and αglucosidase enzymes (Smirin et al, 2010;Park et al, 2012;Misbah et al, 2013;Saravanan and Parimelazhagan, 2014;Oboh et al, 2014;Asghari et al, 2015;Guder et al, 2015;Adefegha et al, 2016;Loizzo et al, 2016;Khatib et al, 2017;Elyasiyan et al, 2017;Sekar et al, 2017;Putri et al, 2017;Wei et al, 2017;Doan et al, 2018;Sukiman et al, 2018;Yegin et al, 2018;Hyun and Kim 2018;Hwang, 2018;Yegin et al, 2018;Deniz et al, 2018;Raimov and Fakir., 2018;Incegul et al, 2018;Marmouzi et al, 2019;Mohammed et al, 2019;Simomara et al, 2019). Juniperus communis, Eugenia jambolana, Foeniculum vulgare, Secale cereale L., Carum carvi and Capparis spinosa L., Rosa canina L., Rhus coriaria L., Phaleria macrocarpa, Persea americana Mil., Pithecellobium dulcee Benth, Carum carvi, Vacciniummyrtillus, Backhousia citriodora oil, Vanilla planifolia Andrews were analyzed for their antidiabetic effects using STZ or alloxan induced rats (Medina et al, 1993;Kelkar and Kaklij (1997);Ozbek, 2002;Ozbek et al, 2002;Eddouks et al, 2004;Orhan et al, 2009;…”

Apple Tepache fermented with tibicos: Changes in chemical profiles, antioxidant activity and inhibition of digestive enzymes

“…The α-glucosidase is another digestive enzyme; it has been suggested that caffeic acid and procyanidin B dimer compounds insertion alters catalytic configuration reducing therefore its affinity to bind to the substrate (Wei et al, 2017). The caffeic acid and its derivatives, as 5-caffeoylquinic acid, have been reported as α-glucosidase inhibitors (Kalita et al, 2018).…”