Novel insights of disability assessment in adult myositis

Espinosa-Ortega, Fabricio; Moreno-Ramírez, Mariana; Alexanderson, Helene

doi:10.1097/bor.0000000000000433

Cited by 5 publications

(2 citation statements)

References 47 publications

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“…In clinical practice just as much as in clinical studies, clinical scales are required that allow a quick and reliable comparison of two visits of the patient (see [ 165 ] for a recent overview). This is indispensable for a consistent evaluation of the treatment and decisions of dose escalation including the switch to a more aggressive drug.…”

Section: Assessments Of the Disease Course And Overview Of Relevant Cmentioning

confidence: 99%

Current Classification and Management of Inflammatory Myopathies

Schmidt

2018

Journal of Neuromuscular Diseases

235

199

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Inflammatory disorders of the skeletal muscle include polymyositis (PM), dermatomyositis (DM), (immune mediated) necrotizing myopathy (NM), overlap syndrome with myositis (overlap myositis, OM) including anti-synthetase syndrome (ASS), and inclusion body myositis (IBM). Whereas DM occurs in children and adults, all other forms of myositis mostly develop in middle aged individuals. Apart from a slowly progressive, chronic disease course in IBM, patients with myositis typically present with a subacute onset of weakness of arms and legs, often associated with pain and clearly elevated creatine kinase in the serum. PM, DM and most patients with NM and OM usually respond to immunosuppressive therapy, whereas IBM is largely refractory to treatment. The diagnosis of myositis requires careful and combinatorial assessment of (1) clinical symptoms including pattern of weakness and paraclinical tests such as MRI of the muscle and electromyography (EMG), (2) broad analysis of auto-antibodies associated with myositis, and (3) detailed histopathological work-up of a skeletal muscle biopsy. This review provides a comprehensive overview of the current classification, diagnostic pathway, treatment regimen and pathomechanistic understanding of myositis.

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Section: Assessments Of the Disease Course And Overview Of Relevant Cmentioning

confidence: 99%

Current Classification and Management of Inflammatory Myopathies

Schmidt

2018

Journal of Neuromuscular Diseases

235

199

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“…HAQ, when performed as an isolated tool, does not cover all areas included in the International Classification of Functioning, Disability and Health. Although it provides a detailed assessment in the field of activity limitation and to some extent participation restriction it does not assess impairment resulting from body functions and structures and also neglects the importance of environmental and personal factors [18]. Moreover, it does not include social or mental health as well as sensory organ impairment [6].…”

Section: Study Limitations and Advantagesmentioning

confidence: 99%

Disability in idiopathic inflammatory myopathies: questionnaire-based study

2019

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Idiopathic inflammatory myopathies (IIM) are progressive, debilitating diseases that can lead to severe impairment. The aim of the study was to evaluate the level of disability and compare it between different subtypes of IIM as well as to estimate clinical symptoms associated with greater risk of disability and distinguish the most troublesome activities in this group of patients. A online form concerning clinical symptoms, comorbidities and limitations in daily living was created and distributed to online support groups for patients with IIM. Health Assessment Questionnaire was used to estimate disability and physical limitations while visual analogue scales enabled to assess the intensity of clinical symptoms. 361 out of 377 responders were included for further evaluation. High prevalence of disability was observed in each subtype yet predominantly in patients with inclusion body myositis (IBM) as 51.43% of them fulfilled the criteria of severe to very severe disability. Level of disability correlated with muscle weakness, tolerance of physical activity and level of fatigue. 45.62% of responders in general required walking devices and 43.50% of participants declared using facilitating devices for maintaining hygiene. Patients with IIM encounter multitude physical limitations that can be partially compensated by usage of facilitating devices or aid of the caregivers. IBM seems to be the most disabling subtype.

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Assessment of Physical Activity and Muscle Function in Adult Inflammatory Myopathies

Gregory

Saygın

2022

Curr Rheumatol Rep

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Novel insights of disability assessment in adult myositis

Cited by 5 publications

References 47 publications

Current Classification and Management of Inflammatory Myopathies

Current Classification and Management of Inflammatory Myopathies

Disability in idiopathic inflammatory myopathies: questionnaire-based study

Assessment of Physical Activity and Muscle Function in Adult Inflammatory Myopathies

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