Novel Insights on Nutrient Management of Sarcopenia in Elderly

Rondanelli, Mariangela; Faliva, Milena Anna; Monteferrario, Francesca; Peroni, Gabriella; Repaci, Erica; Allieri, Francesca; Perna, Simone

doi:10.1155/2015/524948

Cited by 65 publications

(55 citation statements)

References 130 publications

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“…Recent studies suggest that caloric restriction can improve muscle regenerative capacity by improving satellite cell function in aging skeletal muscle accompanied by improve preservation of muscle mass and strength with aging [4, 5]. The rational approach to prevent sarcopenia is the combination of proper nutrition, possibly associated with the use of dietary supplements, and a regular exercise program [6]. …”

Section: Introductionmentioning

confidence: 99%

Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts

Lee

Leem

et al. 2017

PLoS ONE

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Prevention of age-associated reduction in muscle mass and function is required to manage a healthy life. Supplemental (-)-Epicatechin (EC) appears to act as a potential regulator for muscle growth and strength. However, its cellular and molecular mechanisms as a potential muscle growth agent have not been studied well. In the current study, we investigated a role of EC in differentiation of muscle progenitors to gain the molecular insight into how EC regulates muscle growth. EC enhanced myogenic differentiation in a dose-dependent manner through stimulation of promyogenic signaling pathways, p38MAPK and Akt. EC treatment elevated MyoD activity by enhancing its heterodimerization with E protein. Consistently, EC also positively regulated myogenic conversion and differentiation of fibroblasts. In conclusion, EC has a potential as a therapeutic or nutraceutical remedy to treat degenerative muscle diseases or age-related muscle weakness.

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Section: Introductionmentioning

confidence: 99%

Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts

Lee

Leem

et al. 2017

PLoS ONE

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“…Esse dado corrobora a literatura estudada, em que foram utilizados os critérios do EWGSOP, demonstrando que o IMC foi negativamente associado à sarcopenia. Indivíduos com IMC mais baixo foram mais propensos a serem sarcopê-nicos do que aqueles com IMC mais alto (36) . Isto pode ser um indicador importante para pesquisas futuras nessa população, pois o IMC é uma medida de fácil mensuração, não invasiva e com prognóstico para piores quantidades de massa muscular.…”

Section: Figura 1 Algoritmo Proposto Pelo Ewgsop Administrado Em Idounclassified

Idosos Quilombolas: Prevalência De Sarcopenia Utilizando O Algoritmo Proposto Pelo European Working Group on Sarcopenia in Older People

Neto¹,

Karnikowski²,

Osório³

et al. 2016

ACS

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Conflito de interesses: Não Contribuição dos autores:LSSN participou da concepção do projeto e elaboração do projeto, treinamento, coleta de dados, redação e revisão do manuscrito. MGOK realizou as análises, descrição dos resultados e da redação do manuscrito. NBO participou da coleta dos dados e da redação do manuscrito. LCP participou da redação do manuscrito. LBG participou da revisão do manuscrito. JPCM participou revisão crítica do conteúdo escrito e analisado, além da aprovação final e de ser corresponsável pela garantia da exatidão e integridade da obra. Contato para correspondência: Luiz Sinesio Silva Neto E-mail: luizneto@uft.edu. Descritores: Sarcopenia; Prevalência; Idoso; Grupo com Ancestrais do Continente Africano ABSTRACT Introduction: Sarcopenia is considered a geriatric syndrome. Currently, there is no agreed definition of sarcopenia, so it is still a challenge to establish the actual prevalence of sarcopenia in the elderly in different races / ethnicities, especially in elderly quilombolas. Objective: Identify sarcopenia in the elderly living in maroon settlement using the algorithm proposed by the European Working Group on Sarcopenia in Older People. Patients and Methods: This is a cross-sectional study with 70 participants (SD 65.58 ± 6.67 years) men and women living in the Quilombo communities called Malhadinha and Córrego Fundo, located in the city of Brejinho Nazaré-Tocantins-Brazil. For the diagnosis of sarcopenia we used the recommendations proposed by the European Working Group on Sarcopenia in Older People. Muscle mass was analyzed by the Dual-energy X-ray absorptiometry and the handgrip strength by hand dynamometer. The physical performance was analyzed using the walking speed test. We used the SF-36 questionnaire to analyze the quality of life. Results: We identified a prevalence of sarcopenia of 10% in the sample. The sarcopenic individuals were classified as low handgrip strength. All individuals in the sample had adequate physical performance. Conclusions:We conclude that the identification of the prevalence of sarcopenia in the elderly maroons was high. The algorithm proposed by the European Working Group on Sarcopenia in Older People had clinical applicability in the study population.

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“…We chose to address dietary protein intake as it has been demonstrated by Wolfe et al and other investigators that older adults often become deficient in certain amino acids, specifically leucine, which is vital for growth and maintenance of muscle [21, 22, 25-27]. In addition, the elderly also suffer from anabolic resistance which limits their ability to synthesis muscle as compared to younger adults using the same dose of protein [7, 22].…”

Section: Introductionmentioning

confidence: 99%

Feasibility of Conducting a 6-Months Long Home-based Exercise Program with Protein Supplementation in Elderly Community-dwelling Individuals with Heart Failure

et al. 2017

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Objective Cardiac cachexia is a condition associated with heart failure, particularly in the elderly, and is characterized by loss of muscle mass with or without the loss of fat mass. Approximately 15% of elderly heart failure patients will eventually develop cardiac cachexia; such a diagnosis is closely associated with high morbidity and increased mortality. While the mechanism(s) involved in the progression of cardiac cachexia is incompletely established, certain factors appear to be contributory. Dietary deficiencies, impaired bowel perfusion, and metabolic dysfunction all contribute to reduced muscle mass, increased muscle wasting, increased protein degradation, and reduced protein synthesis. Thus slowing or preventing the progression of cardiac cachexia relies heavily on dietary and exercise-based interventions in addition to standard heart failure treatments and medications. Methods The aim of the present study was to test the feasibility of an at-home exercise and nutrition intervention program in a population of elderly with heart failure, in an effort to determine whether dietary protein supplementation and increased physical activity may slow the progression, or prevent the onset, of cardiac cachexia. Frail elderly patients over the age of 55 with symptoms of heart failure from UAMS were enrolled in one of two groups, intervention or control. To assess the effect of protein supplementation and exercise on the development of cardiac cachexia, data on various measures of muscle quality, cardiovascular health, mental status, and quality of life were collected and analyzed from the two groups at the beginning and end of the study period. Results More than 50% of those who were initially enrolled actually completed the 6-month study. While both groups showed some improvement in their study measures, the protein and exercise group showed a greater tendency to improve than the control group by the end of the six months. Conclusion These findings suggest that with a larger cohort, this intervention may show significant positive effects for elderly patients who are at risk of developing cardiac cachexia.

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Novel Insights on Nutrient Management of Sarcopenia in Elderly

Cited by 65 publications

References 130 publications

Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts

Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts

Idosos Quilombolas: Prevalência De Sarcopenia Utilizando O Algoritmo Proposto Pelo European Working Group on Sarcopenia in Older People

Feasibility of Conducting a 6-Months Long Home-based Exercise Program with Protein Supplementation in Elderly Community-dwelling Individuals with Heart Failure

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