Novel Insights on Sex-Related Differences in Asthma

Zhang, Peng; Zein, Joe

doi:10.1007/s11882-019-0878-y

Cited by 23 publications

(13 citation statements)

References 98 publications

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“…The menstrual cycle, pregnancy, and exogenous sex hormones supplementation, in females, affect asthma. Sexual differences in asthma also result from gene polimorphisms including sex specific asthma risk loci and thymic stromal lymphopoietin (TLSP) and estrogen receptor alpha (ESR1) gene polimorphisms [53]. Estrogens up regulate and androgens down regulate Th2 responses.…”

Section: Asthma and Rhinitismentioning

confidence: 99%

“…Also, obese adult females tend to show higher prevalence, incidence, and severity of asthma. The precise mechanism underlying sex specific association of asthma and obesity is still unclear, but recently was reported that human airway smooth muscle cells from obese subjects aged 20-40 had greater cell shortening and greater response to contractile agonists in females than in males [53]. Body fat percentage is lower in males than in females with the same body mass index, and they have higher percentage of visceral fat while the latter have more subcutaneous fat especially in the gluteal-femoral area.…”

Section: Asthma and Rhinitismentioning

confidence: 99%

“…In obese adult females, neutrophilic inflammation is suggested to play a significant role: were found high neutrophil counts in peripheral blood samples and sputum from obese asthmatic women and not in men [53]. E-Lacerda et al showed in a mouse model that the interaction between weight gain and sex alters the progression of allergic asthma: females develop airway remodeling at an earlier stage in respect to males [56].…”

Section: Asthma and Rhinitismentioning

confidence: 99%

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Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

Martinis

Sirufo

Suppa

et al. 2020

IJMS

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Allergies are rapidly worsening in recent decades, representing the most common immunological diseases. The mechanism of disorders such as asthma, rhinocongiuntivitis, urticaria, atopic dermatitis, food and drug allergies, and anaphylaxis still remain unclear and consequently treatments is mostly still symptomatic and aspecific while developments of new therapies are limited. A growing amount of data in the literature shows us how the prevalence of allergic diseases is different in both sexes and its changes over the course of life. Genes, hormones, environmental and immunological factors affect sex disparities associated with the development and control of allergic diseases, while they more rarely are considered and reported regarding their differences related to social, psychological, cultural, economic, and employment aspects. This review describes the available knowledge on the role of sex and gender in allergies in an attempt to improve the indispensable gender perspective whose potential is still underestimated while it represents a significant turning point in research and the clinic. It will offer insights to stimulate exploration of the many aspects still unknown in this relationship that could ameliorate the preventive, diagnostic, and therapeutic strategies in allergic diseases.

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Section: Asthma and Rhinitismentioning

confidence: 99%

Section: Asthma and Rhinitismentioning

confidence: 99%

Section: Asthma and Rhinitismentioning

confidence: 99%

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Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

Martinis

Sirufo

Suppa

et al. 2020

IJMS

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“…The levels of cytokines in women with IBS using hormonal contraceptives showed little difference from healthy controls either using or not using hormonal contraceptives. Although there is ample evidence that estrogen and other sex steroids influence cytokine levels (Kovats, 2015; Zhang & Zein, 2019), there is sparse research related to hormonal contraception in studies of cytokine levels in IBS. One recent study among individuals with IBS reported significantly higher levels of IL-1β among females compared to males, although hormonal contraceptive use and menstrual cycle phase were not considered (Lee et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Cytokine Levels and Symptoms Among Women with Irritable Bowel Syndrome: Considering the Role of Hormonal Contraceptive Use

Kamp

Han

Shulman

et al. 2020

Biological Research For Nursing

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Background: Young to middle-aged women are more likely than men to be diagnosed with irritable bowel syndrome (IBS). Immune dysfunction may be present in IBS, however, few studies have tested whether hormonal contraceptive use is linked to inflammatory markers. The purpose of this study was to compare cytokine levels between women (ages 18–45) with and without IBS and with and without hormonal contraceptive use and to examine the relationships of cytokine levels to IBS gastrointestinal (GI) and non-GI symptoms within those using and not using hormonal contraceptives. Methods: Seventy-three women with IBS and 47 healthy control women completed questionnaires (demographics, hormonal contraceptive use) and kept a 28-day symptom diary. Fasting plasma and LPS-stimulated pro-inflammatory (IL-1β, IL-6, IL-12p40, IL-12p70, IL-8, and TNF-α) and anti-inflammatory (IL-10) cytokines were assayed. Results: No differences were found in plasma or stimulated cytokine levels between IBS and control women. Levels of IL-1β ( p = 0.04) and TNF-α ( p = 0.02) were higher among women who did not use hormonal contraceptives compared to women who used hormonal contraceptives. Among women with IBS, significant correlations were found between daily psychological distress and plasma IL-10, IL-12p70, IL-1β, IL-6, and IL-8 cytokine levels. Conclusions: These results suggest that hormonal contraceptive use might reduce IL-1β and TNF-α cytokine levels in women with IBS. The impact of hormonal contraceptive use on innate immune activation among women with IBS requires further research.

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“…Thus, it may be useful to carry out sex-specific analyses of metabolic signatures in asthma patients and determine whether any observed differences are clinically significant, namely in terms of better predicting clinical and/or inflammatory asthma phenotypes in one of the sexes. This is all the more relevant since there is epidemiological and clinical evidence showing sex-related differences in asthma, at least in part related to sex hormones, which also affect many immunophysiological parameters (reviewed by Zhang and Zein) [ 134 ].…”

Section: Reproducibility and Stability Of Asthma-related Metabolic Signatures: Of Validation Cohorts Time Stability Age Sex And Other Facmentioning

confidence: 99%

Metabolic Phenotypes in Asthmatic Adults: Relationship with Inflammatory and Clinical Phenotypes and Prognostic Implications

et al. 2021

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Bronchial asthma is a chronic disease that affects individuals of all ages. It has a high prevalence and is associated with high morbidity and considerable levels of mortality. However, asthma is not a single disease, and multiple subtypes or phenotypes (clinical, inflammatory or combinations thereof) can be detected, namely in aggregated clusters. Most studies have characterised asthma phenotypes and clusters of phenotypes using mainly clinical and inflammatory parameters. These studies are important because they may have clinical and prognostic implications and may also help to tailor personalised treatment approaches. In addition, various metabolomics studies have helped to further define the metabolic features of asthma, using electronic noses or targeted and untargeted approaches. Besides discriminating between asthma and a healthy state, metabolomics can detect the metabolic signatures associated with some asthma subtypes, namely eosinophilic and non-eosinophilic phenotypes or the obese asthma phenotype, and this may prove very useful in point-of-care application. Furthermore, metabolomics also discriminates between asthma and other “phenotypes” of chronic obstructive airway diseases, such as chronic obstructive pulmonary disease (COPD) or Asthma–COPD Overlap (ACO). However, there are still various aspects that need to be more thoroughly investigated in the context of asthma phenotypes in adequately designed, homogeneous, multicentre studies, using adequate tools and integrating metabolomics into a multiple-level approach.

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Novel Insights on Sex-Related Differences in Asthma

Cited by 23 publications

References 98 publications

Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

Cytokine Levels and Symptoms Among Women with Irritable Bowel Syndrome: Considering the Role of Hormonal Contraceptive Use

Metabolic Phenotypes in Asthmatic Adults: Relationship with Inflammatory and Clinical Phenotypes and Prognostic Implications

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