Novel insights on the treatment of hypercholesterolemia

Predieri, Barbara; Bruzzi, Patrizia

doi:10.1586/17446651.2015.1033373

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Hypercholesterolemia was defined as total cholesterol ≥90 th percentile and borderline elevation as 75–90 th percentile for age and sex. Results below the 75 th percentile was defined as normal 25 …”

Section: Methodsmentioning

confidence: 99%

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The effect of COVID‐19 restriction on metabolic syndrome in primary hypertension

Leventoğlu

Şişik

Çelik

et al. 2022

Pediatrics International

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Background Primary hypertension (HT) has been increasingly reported in parallel to the increase in the prevalence of obesity in children, both of which are important components of metabolic syndrome. The aim of this study was to investigate the effects of COVID‐19 restrictions, which are believed to induce lifestyle changes and physical inactivity, on the parameters of metabolic syndrome in children with primary hypertension. Methods This was an observational, pre‐post study conducted on pediatric patients with primary HT. The first phase of the study was the period prior to when COVID‐19 restrictions were put in place in Turkey, and the second phase was up to the date when the restrictions were lifted. Anthropometric and blood pressure measurements, laboratory tests, and hypertensive‐mediated organ damage at both phases of the study were compared. Results Severe restrictions due to the COVID‐19 pandemic were associated with an increase in mean ± standard deviation body mass index (BMI) (26.4 ± 7.3 vs. 27.2 ± 7.1, P = 0.002), antihypertensive drug use (n = 53 (57.6%) vs. n = 59 (64.1%), P < 0.0001), fasting blood glucose level (89.4 ± 12.6 vs. 94.1 ± 14.2, P = 0.013), and a borderline elevation in total cholesterol (21 [22.8%] vs. 28 [30.4%], P < 0.0001). These increases negatively affected end organs, with an increased frequency of interventricular septum hypertrophy (n = 12 [13%] vs. n = 17 [18.5%], P = 0.031). Conclusions COVID‐19 restrictions were associated with an increased risk of parameters associated with metabolic syndrome in patients with primary hypertension. Physicians should carefully monitor the weight, blood pressure, fasting plasma glucose level, and total cholesterol levels in patients during periods of movement/activity restrictions such as during the COVID‐19 pandemic.

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Section: Methodsmentioning

confidence: 99%

“…Results below the 75 th percentile was defined as normal. 25 Twenty-four-hour urine samples were analyzed for the evaluation of proteinuria and microalbuminuria. Twenty-fourhour protein and microalbumin excretion of >4 mg/m 2 /h and >30 mg/d were defined as proteinuria and microalbuminuria, respectively.…”

Section: Data Collectionmentioning

confidence: 99%

The effect of COVID‐19 restriction on metabolic syndrome in primary hypertension

Leventoğlu

Şişik

Çelik

et al. 2022

Pediatrics International

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Pectin penta-oligogalacturonide reduces cholesterol accumulation by promoting bile acid biosynthesis and excretion in high-cholesterol-fed mice

Zhu

Sun

Hou

et al. 2017

Chemico-Biological Interactions

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Cardiometabolic risk in children and adolescents with obesity: a position paper of the Italian Society for Pediatric Endocrinology and Diabetology

Valerio,

Di Bonito,

Calcaterra

et al. 2024

Ital J Pediatr

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Despite the implementation of preventive measures to counteract the obesity epidemics, the prevalence of childhood obesity is still alarming all over the world. Childhood obesity is the most common risk factor for both cardiovascular and metabolic diseases. In fact, an earlier onset of obesity can cause a greater risk of adiposity tracking across the lifespan and consequently a longer exposure to cardiometabolic risk factors. Accumulating evidence provided by prospective and intervention studies demonstrated the link between pediatric obesity and selected subclinical signs of cardiovascular damage (atherosclerosis and left ventricular hypertrophy), or fatal and not fatal cardiovascular events as early as 40 years of age.The numerous guidelines and scientific documents published in the last years demonstrate the relevance of assessing cardiometabolic risk factors in children and adolescents with OB.This Position paper, released by experts of the “Childhood Obesity study group” within the Italian Society for Pediatric Endocrinology and Diabetology, aims to review the assessment of cardiometabolic risk factors and comorbidities in children and adolescents with OW/OB on the light of the most recent scientific evidence.The main recommendations are: (a) early detection of comorbidities, including hypertension, dyslipidemia, prediabetes/type 2 diabetes, metabolic dysfunction-associated steatotic liver disease, polycystic ovary syndrome, inactivity, obstructive sleep apnea and decline in kidney function; (b) weight loss treatment, which is associated with a reduction of all cardiometabolic risk factors; (c) specific treatment of comorbidities, through lifestyle modifications or pharmacological treatment added to lifestyle for suitable individuals; d). monitoring comorbidities for mitigating future morbidity and mortality.

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Novel insights on the treatment of hypercholesterolemia

Cited by 3 publications

References 21 publications

The effect of COVID‐19 restriction on metabolic syndrome in primary hypertension

The effect of COVID‐19 restriction on metabolic syndrome in primary hypertension

Pectin penta-oligogalacturonide reduces cholesterol accumulation by promoting bile acid biosynthesis and excretion in high-cholesterol-fed mice

Cardiometabolic risk in children and adolescents with obesity: a position paper of the Italian Society for Pediatric Endocrinology and Diabetology

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