Aiming at the shortcomings of the traditional "support-confidence" association rules mining framework and the problems of mining negative association rules, the concept of interestingness measure is introduced. Analyzed the advantages and disadvantages of some commonly used interestingness measures at present, and combined the cosine measure on the basis of the interestingness measure model based on the difference idea, and proposed a new interestingness measure model. The interestingness measure can effectively express the relationship between the antecedent and the subsequent part of the rule. According to this model, an association rules mining algorithm based on the interestingness measure fusion model is proposed to improve the accuracy of mining. Experiments show that the algorithm has better performance and can effectively help mining positive and negative association rules.