Novel interpenetrating smart polymer networks grafted onto polypropylene by gamma radiation for loading and delivery of vancomycin

Muñoz‐Muñoz, Franklin; Ruíz, Juan-Carlos; Alvarez‐Lorenzo, Carmen; Bucio, Emilio

doi:10.1016/j.eurpolymj.2009.04.023

Cited by 41 publications

(16 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some IPN systems have been designed to switch drug release on and off as a function of temperature. Despite the abundant information about IPNs, few papers report the use of ionizing radiation for preparing smart IPNs [190][191][192]. IPNsbased on poly (NIPAAm), and poly (N-acryloxysuccinimide), PNAS, were prepared by a sequential method.…”

Section: Interpenetrating Polymer Networkmentioning

confidence: 99%

“…PNIPAAm, which was polymerized and crosslinked by gamma irradiation, was swelled in a solution of PNAS/polylysine. The phase transition or LCST of PNIPAAm was not affected with the introduction of PNAS in the structure, but compared to PNAS networks the IPN showed a fast response rate to external changes of temperature, improving their potential in field of high performance devices or systems such as rapid actuators and artificial organs [190][191][192]. …”

Section: Interpenetrating Polymer Networkmentioning

confidence: 99%

See 1 more Smart Citation

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

Contreras-García¹,

Bucio²

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

Self Cite

View full text Add to dashboard Cite

By definition, nanomaterials are multifunctional due to the co-incorporation of both therapeutic and bioimaging agents. Among the therapeutic applications of the polymeric nanomaterials are found drug, protein or gene delivery, tissue engineering. Other advances in bioapplications include cell-labeling, cell membrane modeling, agent delivery and targeting. Additionally, imaging nanobiotechnology is applied to sensorization and diagnosis with biosensors and biomarkers for biodetection and bioimaging, respectively. In this chapter are described the different polymeric nanostructures applied to therapy and diagnosis such as polymeric-based core-shell colloid, proteins and peptides, drug conjugates and complexes with synthetic polymers, dendrimers, vesicles, micelles, carbon nanotubes, biopolymers, smart nano polymers, metal-polymer complexes, enzyme-responsive nanoparticles, and hybrid polymeric nanomaterials. The different types of polymers are fabricated using several approaches ranging from conventional chemical methods to more sophisticated processes such as surface modification using ionizing radiation to obtain layers free of pollutants without purification and isolation processes among other advantages.

show abstract

Section: Interpenetrating Polymer Networkmentioning

confidence: 99%

Section: Interpenetrating Polymer Networkmentioning

confidence: 99%

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

Contreras-García¹,

Bucio²

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

Self Cite

View full text Add to dashboard Cite

show abstract

“…Acrylic acid sodium salt was identified as suitable for interacting with the drug. Then, interpenetrated networks of poly(acrylic acid) and PNIPAAm were prepared by grafting to the substrate one of the networks followed by polymerization/cross-linking of the second network [284]. The resultant functionalized surfaces were dually pH and temperature responsive (Figure 18.20), exhibited a synergistic loading mechanism, and were able to release vancomycin at a rate suitable to prevent in vitro the formation of methicillin-resistant Staphylococcus aureus (MRSA) biofilms [283,285].…”

Section: Grafting Onto Medical Devicesmentioning

confidence: 99%

Nanostructures and Nanostructured Networks for Smart Drug Delivery

Álvarez-Lorenzo

Puga

2012

Biomimetic Approaches for Biomaterials Development

Self Cite

View full text Add to dashboard Cite

“…Este polímero presentó una alta sensibilidad a la temperatura y al pH del medio, y adicionalmente mostró alta capacidad de carga de vancomicina. Sin embargo, luego fue realizada la síntesis de estas IPNs, utilizando radiación γ en todas las etapas involucradas en su síntesis, con la finalidad de reducir los riesgos tóxicos de incluir iniciadores redox para la polimerización de AAc [93].…”

Section: Redes Inteligentes Interpenetradas (Ipns)unclassified

Radiación gamma para el diseño de sistemas inteligentes en liberación controlada de fármacos e ingeniería de tejidos

Muñoz‐Muñoz¹,

Contreras-García²,

Bucio³

et al.

Biomateriais Aplicados Ao Desenvolvimento De Sistemas Terapêuticos Avançados

Self Cite

View full text Add to dashboard Cite

A navegação consulta e descarregamento dos títulos inseridos nas Bibliotecas Digitais UC Digitalis, UC Pombalina e UC Impactum, pressupõem a aceitação plena e sem reservas dos Termos e Condições de Uso destas Bibliotecas Digitais, disponíveis em https://digitalis.uc.pt/pt-pt/termos.Conforme exposto nos referidos Termos e Condições de Uso, o descarregamento de títulos de acesso restrito requer uma licença válida de autorização devendo o utilizador aceder ao(s) documento(s) a partir de um endereço de IP da instituição detentora da supramencionada licença.Ao utilizador é apenas permitido o descarregamento para uso pessoal, pelo que o emprego do(s) título(s) descarregado(s) para outro fim, designadamente comercial, carece de autorização do respetivo autor ou editor da obra.Na medida em que todas as obras da UC Digitalis se encontram protegidas pelo Código do Direito de Autor e Direitos Conexos e demais legislação aplicável, toda a cópia, parcial ou total, deste documento, nos casos em que é legalmente admitida, deverá conter ou fazer-se acompanhar por este aviso.Radiación gamma para el diseño de sistemas inteligentes en liberación controlada de fármacos e ingeniería de tejidos Autor(es):

show abstract

Novel interpenetrating smart polymer networks grafted onto polypropylene by gamma radiation for loading and delivery of vancomycin

Cited by 41 publications

References 35 publications

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

Nanostructures and Nanostructured Networks for Smart Drug Delivery

Radiación gamma para el diseño de sistemas inteligentes en liberación controlada de fármacos e ingeniería de tejidos

Contact Info

Product

Resources

About