Novel inulin-based mucoadhesive micelles loaded with corticosteroids as potential transcorneal permeation enhancers

Prima, Giulia Di; Saladino, Silvia; Bongiovì, Flavia; Adamo, Giorgia; Ghersi, Giulio; Pitarresi, Giovanna; Giammona, Gaetano

doi:10.1016/j.ejpb.2017.05.005

Cited by 50 publications

(39 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These interesting outcomes proved that the CAC value strongly depends on the ionic strength of the external medium and the pH of the buffer solutions ( Di Prima et al, 2019 ). These results were consistent with those of Di Prima et al (2017) , who found the CAC values for the same inulin derivatives with a similar method, reaching 0.136 mg/mL. In contrast, the CAC for the formation of self-assembling inulin-LA conjugate micelles was demonstrated to be 0.0669 mg/ml ( Wang et al, 2018 ).…”

Section: Chemistry and Synthesis Of Hmisupporting

confidence: 90%

“…Furthermore, Tripodo, Chlapanidas et al (2015) and Tripodo, Pasut et al (2015) prepared INVITE bioconjugates with varying DS and designed a drug delivery system based on mesenchymal stromal cells (MSCs) for the therapy of neurodegenerative diseases, which obtained practical achievements regarding the drug delivery profile. In addition, HMI such as amine derivatives have been grafted with biotin, retinoic acid, and vitamin E to produce mucoadhesive micelles, which exhibit transcorneal permeation properties, as well as long-circulating carriers for receptor-mediated targeted drug delivery ( Di Prima et al, 2017 ; Mandracchia et al, 2018 ). Studies have revealed that inulin serves as a promising transporter for colonic drug delivery because it is not digested in the stomach and small intestine ( Wang et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Potential applications of hydrophobically modified inulin as an active ingredient in functional foods and drugs - A review

Usman

Zhang

Patil

et al. 2021

Carbohydrate Polymers

View full text Add to dashboard Cite

show abstract

Section: Chemistry and Synthesis Of Hmisupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Potential applications of hydrophobically modified inulin as an active ingredient in functional foods and drugs - A review

Usman

Zhang

Patil

et al. 2021

Carbohydrate Polymers

View full text Add to dashboard Cite

show abstract

“…At three different time points (6, 12, and 24 h), the PS and ZP of the dispersions were measured as mentioned previously. Also, the turbidity of the incubated dispersions was evaluated by measuring the transmittance % (T%) spectrophotometrically at λ max 500 nm (Shimadzu UV-1601PC, Kyoto, Japan) (Di Prima et al., 2017 ). The turbidity was calculated according to the following equation (Abdelbary and Tadros, 2013 ): …”

Section: Methodsmentioning

confidence: 99%

Solutol HS15 based binary mixed micelles with penetration enhancers for augmented corneal delivery of sertaconazole nitrate: optimization, in vitro, ex vivo and in vivo characterization

2018

View full text Add to dashboard Cite

Keratomycosis is a serious corneal disease that can cause a permanent visual disability if not treated effectively. Sertaconazole nitrate (STZ), a novel broad spectrum antifungal drug, was suggested as a promising treatment. However, its utility in the ocular route is restricted by its poor solubility, along with other problems facing the ocular delivery like short residence time, and the existing corneal barrier. Therefore, the objective of this study was to formulate STZ loaded binary mixed micelles (STZ-MMs) enriched with different penetration enhancers using thin-film hydration method, based on a 31.22 mixed factorial design. Different formulation variables were examined, namely, type of auxiliary surfactant, type of penetration enhancer, and total surfactants: drug ratio, and their effects on the solubility of STZ in MMs (SM), particle size (PS), polydispersity index (PDI), and zeta potential (ZP) were evaluated. STZ-MMs enhanced STZ aqueous solubility up to 338.82-fold compared to free STZ. Two optimized formulations (MM-8 and MM-11) based on the desirability factor (0.891 and 0.866) were selected by Design expert® software for further investigations. The optimized formulations were imaged by TEM which revealed nanosized spherical micelles. Moreover, they were examined for corneal mucoadhesion, stability upon dilution, storage effect, and ex vivo corneal permeation studies. Finally, both in vivo corneal uptake and in vivo corneal tolerance were investigated. MM-8 showed superiority in the ex vivo and in vivo permeation studies when compared to the STZ-suspension. The obtained results suggest that the aforementioned STZ loaded mixed micellar system could be an effective candidate for Keratomycosis-targeted therapy.

show abstract

“…The combination of natural and synthetic polymers has been proven to provide greater mechanical stability and improve biocompatibility, acquiring from the synergistic properties of both materials. Interestingly, various combinations of collagen with other natural polymers such as inulin [16], or combination of alginate, gelatin and fibrin [17] have been transformed into formulations of injectable hydrogel enabling in situ formation [18]. Due to their ease of encapsulation of cells/biomolecules and subsequent administration in the absence of significant toxic effects, the use of injectable hydrogels represents an interesting strategy for tissue engineering and cell therapy [19].…”

Section: Introductionmentioning

confidence: 99%

Production of Injectable Marine Collagen-Based Hydrogel for the Maintenance of Differentiated Chondrocytes in Tissue Engineering Applications

Rigogliuso

Salamone

Barbarino

et al. 2020

IJMS

Self Cite

View full text Add to dashboard Cite

Cartilage is an avascular tissue with limited ability of self-repair. The use of autologous chondrocyte transplants represent an effective strategy for cell regeneration; however, preserving the differentiated state, which ensures the ability to regenerate damaged cartilage, represents the main challenge during in vitro culturing. For this purpose, we produced an injectable marine collagen-based hydrogel, by mixing native collagen from the jellyfish Rhizostoma pulmo with hydroxy-phenyl-propionic acid (HPA)-functionalized marine gelatin. This biocompatible hydrogel formulation, due to the ability of enzymatically reticulate using horseradish peroxidase (HPR) and H2O2, gives the possibility of trap cells inside, in the absence of cytotoxic effects, during the cross-linking process. Moreover, it enables the modulation of the hydrogel stiffness merely varying the concentration of H2O2 without changes in the concentration of polymer precursors. The maintenance of differentiated chondrocytes in culture was then evaluated via morphological analysis of cell phenotype, GAG production and cytoskeleton organization. Additionally, gene expression profiling of differentiation/dedifferentiation markers provided evidence for the promotion of the chondrogenic gene expression program. This, combined with the biochemical properties of marine collagen, represents a promising strategy for maintaining in vitro the cellular phenotype in the aim of the use of autologous chondrocytes in regenerative medicine practices.

show abstract

Novel inulin-based mucoadhesive micelles loaded with corticosteroids as potential transcorneal permeation enhancers

Cited by 50 publications

References 30 publications

Potential applications of hydrophobically modified inulin as an active ingredient in functional foods and drugs - A review

Potential applications of hydrophobically modified inulin as an active ingredient in functional foods and drugs - A review

Solutol HS15 based binary mixed micelles with penetration enhancers for augmented corneal delivery of sertaconazole nitrate: optimization, in vitro, ex vivo and in vivo characterization

Production of Injectable Marine Collagen-Based Hydrogel for the Maintenance of Differentiated Chondrocytes in Tissue Engineering Applications

Contact Info

Product

Resources

About