Novel ion-doped mesoporous glasses for bone tissue engineering: Study of their structural characteristics influenced by the presence of phosphorous oxide

Abstract

Ion-doped binary SiO 2 -CaO and ternary SiO 2 -CaO-P 2 O 5 mesoporous bioactive glasses were synthesised and characterised to evaluate the influence of P 2 O 5 in the glass network structure.Strontium, copper and cobalt oxides in a proportion of 0.8 mol% were selected as dopants because the osteogenic and angiogenic properties reported for these elements. Although the four glass compositions investigated presented analogous textural properties, TEM analysis revealed that the structure of those containing P 2 O 5 exhibited an increased ordered mesoporosity. Furthermore, 29 Si NMR revealed that the incorporation of P 2 O 5 increased the network connectivity and that this compound captured the Sr 2+, Cu 2+ and Co 2+ ions preventing them to behave as modifiers of the silica network. In addition, 31 P NMR results revealed that the nature of the cation directly influences the characteristics of the phosphate clusters. In this study, we have proven that phosphorous oxide entraps doping-metallic ions, granting these glasses with a greater mesopores order.

Chitosan/hydroxyapatite composite bone tissue engineering scaffolds with dual and decoupled therapeutic ion delivery: copper and strontium

“…TMIs are a main focus of current biomaterials research as they can positively interact with cells and provide a wide range of beneficial effects depending on the specific selected ion (angiogenesis, osteogenesis, improved proliferation or differentiation, antibacterial properties among others). 25,26 Traditional approaches to use TMIs in biomaterials usually aim to combine the beneficial properties of ions embedded in particulate inorganic fillers together with a rather inert polymer matrix by means of composites fabrication. In this pilot study, a further improvement is proposed: the possibility to use TMI-carrying biomaterials in both phases of the composite is explored, effectively increasing the spectrum of properties that the final construct is able to deliver.…”

Applications of Metals for Bone Regeneration

“…Together, the different metal ions have functional roles in the physiological cellular environment as well as in the course of bone healing. Thus, the application of metal ions in combination with the above-mentioned bone substitutes or singularly, is of special interest for bone regeneration [ 46 , 47 , 48 ]. To provide an overview of the regenerative potential of the different metal ions, the present review summarizes the knowledge about their involvement in cellular processes and the bone healing process, with a further focus on studies that have already analyzed the regenerative potential of bone substitutes, including metals.…”

Applications of Metals for Bone Regeneration

“…Altogether, the different metal ions have functional roles in the physiological cellular environment and also in the course of bone healing. Thus, the application of metal ions in combination with the above-mentioned bone substitutes or solely is of special interest for bone regeneration [46][47][48]. To give an overview of the regenerative potential of the different metal ions the present review summarizes the knowledge about their involvement in cellular processes and the bone healing process.…”