Novel Ionophore for the Potentiometric Determination of Cetirizine Hydrochloride in Pharmaceutical Formulations and Human Urine

Rizk, Nashwa M. H.; Abbas, Samah S.; Elsayed, Fathy A.; Abo‐Bakr, Ahmed M.

doi:10.1016/s1452-3981(23)15150-9

Cited by 32 publications

(3 citation statements)

References 23 publications

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“…CTZ medications are generally obtained in tablet and syrup forms. The overindulgence of CTZ in the body can cause headache, unclear vision, constipation, and wooziness [4,5] …”

Section: Methodsmentioning

confidence: 99%

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Electrochemical Analysis of the Antihistamine Drug Cetirizine at a Poly(Glutamine) Modified Carbon Nanotube Paste Electrode

Pushpanjali,

Manjunatha,

Hareesha

et al. 2023

ChemistrySelect

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An inexpensive and efficient sensor was developed for the electrochemical analysis of the antihistamine drug cetirizine (CTZ). The active sites on the bare carbon nanotube paste electrode surface were improved by the electropolymerization of poly(Glutamine). This modified electrode enhances the electrochemical response of the examining molecule. The study was conducted using a cyclic voltammetry technique in phosphate buffer saline of physiological pH 7.0 at a scan rate of 0.1 V/s. The developed electrode possesses increased conductance and declined overpotential for the determination of CTZ. At the optimized conditions, the detection limit was evaluated by obtaining the current response of CTZ at the varied concentration, and it was obtained as 0.12 μM. The poly glutamine modified carbon nanotube paste electrode was successfully applied to determine CTZ in tablet and human urine samples with acceptable recovery.

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“…CTZ medications are generally obtained in tablet and syrup forms. The overindulgence of CTZ in the body can cause headache, unclear vision, constipation, and wooziness [4,5] …”

Section: Methodsmentioning

confidence: 99%

“…The overindulgence of CTZ in the body can cause headache, unclear vision, constipation, and wooziness. [4,5] Drug molecule testing is highly applicable in the field of quality control. Since, these molecules have many therapeutic applications, their quantification in the minute trace is of great significance.…”

mentioning

confidence: 99%

Electrochemical Analysis of the Antihistamine Drug Cetirizine at a Poly(Glutamine) Modified Carbon Nanotube Paste Electrode

Pushpanjali,

Manjunatha,

Hareesha

et al. 2023

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…Numerous approaches have been tried for the determination of CET, including gas chromatography [8], calorimetry [9], high-performance liquid chromatography [10], potentiometry [11], electrophoresis [12], and some spectroscopic methods [9,13]. These techniques are costly, time-consuming, and require the preparation of an excessive quantity of test samples.…”

Section: Introductionmentioning

confidence: 99%

Zinc Oxide–Graphene Nanocomposite-Based Sensor for the Electrochemical Determination of Cetirizine

et al. 2022

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A nanocomposite electrode of graphene (Gr) and zinc oxide (ZnO) nanoparticles was fabricated to study the electrochemical oxidation behavior of an anti-inflammatory drug, i.e., cetirizine (CET). The voltametric response of CET for bare CPE, Gr/CPE, ZnO/CPE, and the ZnO-Gr nanocomposite electrode was studied. The modifier materials were characterized using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and X-ray powder diffraction (XRD) to comprehend the surface morphology of the utilized modifiers. The influence of pH, scan rate, and accumulation time on the electrooxidation of CET was examined. It was found that the electrochemical oxidation of CET was diffusion-controlled, in which two protons and two electrons participated. The detection limit was found to be 2.8 × 10−8 M in a linearity range of 0.05–4.0 µM. Study of excipients was also performed, and it was found that they had negligible interference with the peak potential of CET. The validation and utility of the fabricated nanocomposite sensor material were examined by analyzing clinical and biological samples. Stability testing of the nanocomposite electrode was conducted to assess the reproducibility, determining that the developed biosensor has good stability and high efficiency in producing reproducible results.

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Flow injection–chemiluminescence determination of cetirizine dihydrochloride in pharmaceuticals using tris(2,2′‐bipyridyl)ruthenium (II)–Ag(III) complex reaction

et al. 2020

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A simple and sensitive flow injection–chemiluminescence (FI–CL) method was developed for determination of cetirizine dihydrochloride (CTZH) in pharmaceuticals. The method is primarily based on the enhancement effect of CTZH on the tris(2,2′‐bipyridyl)ruthenium (II)–diperiodatoargentate (III) ([Ru(bpy)3]2+–Ag(III) complex) CL system in an acidic medium. The optimum investigated variables of the CL reaction were: [Ru(bpy)3]2+, 50 × 10−6 mol/L; sulfuric acid, 1.0 × 10−3 mol/L; Ag(III) complex, 100 × 10−6 mol/L; potassium hydroxide, 1.0 × 10−3 mol/L; flow rate, 3.0 ml/min and sample loop volume, 300 μl. The detection and quantification limits were 2.0 × 10−4 and 5.0 × 10−4 mg/L (S/N of 3 and 10) respectively with a linear calibration range of 5.0 × 10−4 to 7.5 mg/L (R2 = 0.9999, n = 11), injection throughput of 110/h and the relative standard deviations of 1.5–3.5% over the range studied. The methodology was successfully applied to determine CTZH in different pharmaceutical samples and validated with a high‐performance liquid chromatography method, and resulted in the recovery of 94.6–108.6%. The probable CL reaction mechanism is described in brief.

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Novel Ionophore for the Potentiometric Determination of Cetirizine Hydrochloride in Pharmaceutical Formulations and Human Urine

Cited by 32 publications

References 23 publications

Electrochemical Analysis of the Antihistamine Drug Cetirizine at a Poly(Glutamine) Modified Carbon Nanotube Paste Electrode

Electrochemical Analysis of the Antihistamine Drug Cetirizine at a Poly(Glutamine) Modified Carbon Nanotube Paste Electrode

Zinc Oxide–Graphene Nanocomposite-Based Sensor for the Electrochemical Determination of Cetirizine

Flow injection–chemiluminescence determination of cetirizine dihydrochloride in pharmaceuticals using tris(2,2′‐bipyridyl)ruthenium (II)–Ag(III) complex reaction

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