Novel isomarabarican triterpenes, exhibiting selective anti-proliferative activity against vascular endothelial cells, from marine sponge Rhabdastrella globostellata

Aoki, Shunji; Sanagawa, Mami; Watanabe, Yasuo; Setiawan, Andi; Arai, Masayoshi; Kobayashi, Mariko

doi:10.1016/j.bmc.2007.04.070

Cited by 38 publications

(33 citation statements)

References 13 publications

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“…Especially, bastadin 6 completely blocked the VEGF-or bFGF-induced in vivo neovascularization in the mice corneal assay and also suppressed the growth of the s.c.-inoculated A431 solid tumor in nude mice [4]. In the continuous screening from medicinal plant resources, we isolated triterpenoidal saponins [7][8][9] [senegin II (1), senegin III (2), senegin IV (3), senegasaponin a (4), and senegasaponin b (5)] as selective anti-proliferative substances against human umbilical vein endothelial cells (HUVECs) from Polygala senega. Senega Radix, the root of Polygala senega, has been used clinically as an expectorant.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, we isolated several anti-angiogenic substances such as bastadin 6 [4] (a cyclic tetramer of brominatedtyrosine derivative), globostellatic acid X methyl esters [5] (novel isomarabarican triterpenes), and cortistatins [6] (novel steroidal alkaloids) from marine sponges. Especially, bastadin 6 completely blocked the VEGF-or bFGF-induced in vivo neovascularization in the mice corneal assay and also suppressed the growth of the s.c.-inoculated A431 solid tumor in nude mice [4].…”

Section: Introductionmentioning

confidence: 99%

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Anti-angiogenic effect of triterpenoidal saponins from Polygala senega

et al. 2010

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Senegasaponins [senegin II (1), senegin III (2), senegin IV (3), senegasaponin a (4), and senegasaponin b (5)] from Polygala senega were re-discovered as selective anti-proliferative substances against human umbilical vein endothelial cells (HUVECs). Senegasaponins (1-5) showed anti-proliferative activity against HUVECs with IC(50) values in the range 0.6-6.2 μM, and the selective index was 7-100-fold in comparison with those for several cancer cell lines, while the desacyl mixture of senegasaponins (6) and tenuifolin (7) lost anti-proliferative activity, indicating that the 28-O-glycoside moiety and methoxycinnamoyl group were essential for the HUVEC-selective growth inhibition of senegasaponins. Senegin III (2) inhibited the vascular endothelial growth factor (VEGF)-induced in vitro tubular formation of HUVECs and basic fibroblast growth factor (bFGF)-induced in vivo neovascularization in the mouse Matrigel plug assay. Moreover, senegin III (2) suppressed tumor growth in the ddY mice s.c.-inoculated murine sarcoma S180 cells. The analysis of the action mechanism of senegin III (2) suggested that the induction of pigment epithelium-derived factor (PEDF) would contribute to the anti-angiogenic effects of senegasaponins.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-angiogenic effect of triterpenoidal saponins from Polygala senega

et al. 2010

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“…Globostellatic acid X methyl esters and isomarabarican-type triterpenes, isolated from Rhabdastrella globostellata, exhibited selective anti-proliferative activity as well as bFGF-induced tubular formation and VEGF-induced migration in HUVECs [151]. It induced apoptosis in endothelial cells, and the antiproliferative activity did not correlated to an inhibition of the VEGF-induced phosphorylation of ERK1/2 in HUVECs.…”

Section: Compounds That Inhibit One or Several Specific Functions Ofmentioning

confidence: 98%

Marine Sponge Derived Antiangiogenic Compounds

Quesada

Martínez‐Poveda

Rodriguez-Nieto³

et al. 2014

Handbook of Anticancer Drugs From Marine Origin

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Angiogenesis plays an essential role in tumor growth, invasion, and metastasis. Inhibition of angiogenesis has become a major challenge in the development of new anticancer agents, with a countless number of antiangiogenic strategies being tested in preclinical and clinical trials. Nowadays the clinical development of antiangiogenic therapies seems to be unstoppable, not only for cancer, but also for an increasing number of non-neoplasic angiogenesis-related diseases. Although most of the natural compounds previously described as inhibitors of angiogenesis have been isolated from plants and terrestrial microorganisms, increasing attention is being paid to the development of marine-derived antiangiogenic agents. Marine organisms produce interesting and singular pharmacological lead compounds, derived from the large diversity of marine habitats and environmental conditions. Among the many different types of marine organisms used as a source for drug discovery, sponges represent one of the most promising sources of leads in the research of new cancer drugs. There are different strategies for angiogenesis intervention, based on the modulation of any of the different steps of the angiogenic process. In this chapter, we will provide an overview of the angiogenesis inhibitors isolated from marine sponges based on the available information regarding their primary targets or mechanism of action.

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“…Corticium simplex A family of alkaloids named cortistatins A (24) to D (27), with a highly oxidized and rearranged steroidal skeleton, was identified from the Indonesian marine sponge Corticium simplex as HUVEC-selective anti-proliferative substances 30) ( Fig. 5).…”

Section: Cortistatins From the Marine Spongementioning

confidence: 99%

Search for Anti-angiogenic Substances from Natural Sources

Kotoku

Arai

Kobayashi

2016

CHEMICAL & PHARMACEUTICAL BULLETIN

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As angiogenesis is critical for tumor growth and metastasis, potent and selective anti-angiogenic agents with novel modes of action are highly needed for anti-cancer drug discovery. In this review, our studies focusing on the search for anti-angiogenic substances from natural sources, such as bastadins, globostellatic acid X methyl esters and cortistatins from marine sponges, and pyripyropenes from marine-derived fungus, together with senegasaponins from medicinal plant, are summarized.

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Novel isomarabarican triterpenes, exhibiting selective anti-proliferative activity against vascular endothelial cells, from marine sponge Rhabdastrella globostellata

Cited by 38 publications

References 13 publications

Anti-angiogenic effect of triterpenoidal saponins from Polygala senega

Anti-angiogenic effect of triterpenoidal saponins from Polygala senega

Marine Sponge Derived Antiangiogenic Compounds

Search for Anti-angiogenic Substances from Natural Sources

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