Novel isonahocol E3 exhibits anti-inflammatory and anti-angiogenic effects in endothelin-1-stimulated human keratinocytes

Sah, Shrawan Kumar; Kim, Byung-Hak; Park, Geon Tae; Kim, Sunghwan; Jang, Kyu‐Ha; Jeon, Ju Eun; Shin, Jongheon

doi:10.1016/j.ejphar.2013.09.077

Cited by 11 publications

(8 citation statements)

References 30 publications

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“…Some purified compounds of Sargassum , which have been tested for anti-inflammatory activity, include: (1) Terpenoid compounds, such as tuberatolide B, loliolide, sargachromenol, sargachromanol D, sargachromanol G, sargaquinoic acid, sargahydroquinoic acid, isoketochabrolic acid/IKCA, isonahocol E3, and fucosterol fucosterol [19,26,116,117,118,119,120,121,122,123,124,125,126,127,128,129]; (2) fucoxanthin and apo-9’-fucoxanthinone [27,117,130,131,132,133]; (3) the polysaccharide group, including alginic acid and pure FCSPs [134,135,136,137,138,139,140,141]; (4) phenolic compounds (phlorotannins) [142,143]; and (5) other groups, such as aryl polyketide lactones and grasshopper ketones [65,144,145]. A summary can be seen in Table 3 and Table 4.…”

Section: Sargassum Species Are a Source Of Anti-inflammatory Agentsmentioning

confidence: 99%

“…Alongside the trends occurring in crude extract screening studies, studies on the anti-inflammatory activity of Sargassum purified compounds are still dominated by subtropical samples [19,27,65,108,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,137,140,141,142,143,145,147]. Studies on the anti-inflammatory activity of tropical Sargassum purified compounds were carried out by Fernando et al [26], Maneesh and Chakraborty [136,144], Sarithakumari et al [138], and Sarithakumari and Kurup [139].…”

Section: The Potency Of Tropical Sargassum As An Anti-inflammatorymentioning

confidence: 99%

“…An NF-kB-dependent luciferase activity assay is able to monitor NF-kB binding into the DNA binding site [83,132]. Activation of the MAPK protein is usually indicated by levels of the phosphorylated MAPK protein (p38, JNK, and/or ERK1/2) in the cytoplasmic cell extract [26,69,73,75,100,103,116,118,127,128,129,132,135,147] or by an AP-1-dependent luciferase activity assay [132]. Besides inhibiting NF-kB and MAPK group activation, the Sargassum bioactive compound (ethanolic extract of S .…”

Section: Anti-inflammatory Mechanisms Of Bioactive Compounds Of Samentioning

confidence: 99%

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Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

et al. 2019

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Sargassum is recognized both empirically and scientifically as a potential anti-inflammatory agent. Inflammation is an important response in the body that helps to overcome various challenges to body homeostasis such as microbial infections, tissue stress, and certain injuries. Excessive and uncontrolled inflammatory conditions can affect the pathogenesis of various diseases. This review aims to explore the potential of Sargassum's anti-inflammatory activity, not only in crude extracts but also in sulfated polysaccharides and purified compounds. The tropical region has a promising availability of Sargassum biomass because its climate allows for the optimal growth of seaweed throughout the year. This is important for its commercial utilization as functional ingredients for both food and non-food applications. To the best of our knowledge, studies related to Sargassum's anti-inflammatory activity are still dominated by subtropical species. Studies on tropical Sargassum are mainly focused on the polysaccharides group, though there are some other potentially bioactive compounds such as polyphenols, terpenoids, fucoxanthin, fatty acids and their derivatives, typical polar lipids, and other groups. Information on the modulation mechanism of Sargassum's bioactive compounds on the inflammatory response is also discussed here, but specific mechanisms related to the interaction between bioactive compounds and targets in cells still need to be further studied.

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Section: Sargassum Species Are a Source Of Anti-inflammatory Agentsmentioning

confidence: 99%

Section: The Potency Of Tropical Sargassum As An Anti-inflammatorymentioning

confidence: 99%

Section: Anti-inflammatory Mechanisms Of Bioactive Compounds Of Samentioning

confidence: 99%

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Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

et al. 2019

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“…ET-1 is also known to be an autocrine growth factor for keratinocytes [35,36]. Therefore, the increase in ET-1 production in keratinocytes stimulated with HDM extracts in the present study implies the possibility that HDM-derived allergens may be also involved in enhanced proliferation of keratinocytes in the skin of AD patients.…”

Section: Discussionmentioning

confidence: 52%

House Dust Mites Induce Production of Endothelin-1 and Matrix Metalloproteinase-9 in Keratinocytes via Proteinase-Activated Receptor-2 Activation

Yamada¹,

Matsumoto²

2017

Int Arch Allergy Immunol

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Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunction and abnormal immune response. House dust mites (HDM) are a major source of allergens, some of which have cysteine and serine protease activities. Keratinocytes stimulated by HDM-derived proteases have been suggested to contribute to the pathogenesis of AD by producing various cytokines. However, whether keratinocytes contribute to the induction of pruritus in AD, especially by producing pruritus-related mediators upon stimulation with HDM-derived proteases, has not been fully elucidated. Methods: We examined whether the production of endothelin-1 (ET-1), matrix metalloproteinase (MMP)-2, and MMP-9 in keratinocytes can be induced by stimulation with Dermatophagoides farinae extracts, and if so, whether pretreatment with a protease inhibitor or proteinase-activated receptor-2 (PAR-2) antagonist affects the production of these mediators in keratinocytes. Results: Although MMP-2 levels were undetectable in the culture supernatants, the production of ET-1 and MMP-9 was increased upon stimulation with HDM extracts in a concentration- and time-dependent manner and suppressed by pretreatment of HDM extracts with serine protease inhibitor, but not with cysteine protease inhibitor. Mite-derived serine proteases also induced ET-1 and MMP-9 production in a concentration- and time-dependent manner. Moreover, pretreatment with a PAR-2 antagonist inhibited the production of ET-1 and MMP-9 in keratinocytes. Conclusion: These results suggest that the activation of PAR-2 on keratinocytes by HDM-derived serine proteases induces the production of ET-1 and MMP-9, and may contribute to the induction of pruritus in AD.

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“…In addition to its vasoconstrictive properties, some of the important functions of ET-1 include regulating cell signalling and inflammatory processes [16][17][18] , and increased ET-1 expression is found in many diseases [19][20][21][22][23] . Besides its systemic functions, ET-1 exerts important biological functions in the skin, including in keratinocyte proliferation, leukocyte migration, and angiogenesis, which are also characteristic features of psoriasis 10,24 . Furthermore, it was recently reported that ET-1-stimurated bone-marrow-derived dendritic cells (BMDCs) prime T cells to produce Th1 and Th17 cytokines 18 .…”

mentioning

confidence: 99%

Topical application of endothelin receptor A antagonist attenuates imiquimod-induced psoriasiform skin inflammation

Nakahara

Kido‐Nakahara

Ulzii

et al. 2020

Sci Rep

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Endothelin-1 (ET-1) is well known as the most potent vasoconstrictor, and can evoke histamineindependent pruritus. Recently, its involvement in cutaneous inflammation has begun to draw attention. The upregulation of ET-1 expression in the epidermis of human psoriasis patients has been reported. It was also demonstrated that ET-1 can stimulate dendritic cells to induce Th17/1 immune responses. However, the role of the interaction between ET-1 and ET-1 receptors in the pathogenesis of psoriasis remains elusive. Here, we investigated the effects of ET-1 receptor antagonist on imiquimod (IMQ)-induced psoriasiform dermatitis in mouse. Psoriasis-related cytokines such as IL-17A and TNF-α induced ET-1 expression in human keratinocytes. Topical application of selective endothelin A receptor (ETAR) antagonist ambrisentan significantly attenuated the development of IMQ-induced psoriasiform dermatitis and also significantly inhibited the histological inflammation and cytokine expression (TNF-α, IL-12p40, IL-12 p19, and IL-17) in the lesional skin of the mouse model. Furthermore, topical application of ambrisentan suppressed phenotypic and functional activation of dendritic cells in lymph nodes. Our findings indicate that the ET-1 and ETAR axis plays an important role in the pathogenesis of psoriasis and is a potential therapeutic target for treating psoriasis.

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Novel isonahocol E3 exhibits anti-inflammatory and anti-angiogenic effects in endothelin-1-stimulated human keratinocytes

Cited by 11 publications

References 30 publications

Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

House Dust Mites Induce Production of Endothelin-1 and Matrix Metalloproteinase-9 in Keratinocytes via Proteinase-Activated Receptor-2 Activation

Topical application of endothelin receptor A antagonist attenuates imiquimod-induced psoriasiform skin inflammation

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