Novel long-acting brimonidine tartrate loaded-PCL/PVP nanofibers for versatile biomedical applications: fabrication, characterization and antimicrobial evaluation

Salim, Samar A.; Badawi, Noha M.; EL-Moslamy, Shahira H.; Kamoun, Elbadawy A.; Daihom, Baher

doi:10.1039/d3ra02244g

Cited by 9 publications

(1 citation statement)

References 51 publications

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“…In this sense, nanomedicine opened a new frontier for pharmacotherapeutic approaches that can improve the passive penetration of drugs [14,15]. Currently, nanoformulations are widely applied in cosmetic products [1,16]. Electrospun fibers are particularly intriguing for their versatility in the biomedical field [17].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibers Encapsulated with Natural Products: A Novel Strategy to Counteract Skin Aging

Serra,

Garroni,

Cruciani

et al. 2024

IJMS

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The skin is the primary tissue affected by wounds and aging, significantly impacting its protective function. Natural products are widely used in cosmetics, representing a new approach to preventing age-related damage. Nanomedicine combines nanotechnology and traditional treatments to create innovative drugs. The main targets of nanotechnological approaches are wound healing, regeneration, and rejuvenation of skin tissue. The skin barrier is not easily permeable, and the creation of modern nanodevices is a way to improve the passive penetration of substances. In this study, Helichrysum italicum oil (HO) was combined with different types of electrospun nanofibers to study their protective activity on the skin and to evaluate their future application for topical treatments. In the present research, we used biodegradable polymers, including polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP), which were characterized by a scanning electron microscope (SEM). All results show a positive trend in cell proliferation and viability of human skin stem cells (SSCs) and BJ fibroblasts pre-treated with combined nanofibers and then exposed to UV stress. Gene expression analysis revealed the activation of a molecular rejuvenation program in SSCs treated with functionalized nanofibers before UV exposure. Understanding the mechanisms involved in skin changes during aging allows for the future application of nanomaterials combined with HO directly to the patients.

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