Novel low‐grade renal spindle cell neoplasm with HEY1::NCOA2 fusion that is distinct from mesenchymal chondrosarcoma

Abstract

HEY1‐NCOA2 fusion is most described in mesenchymal chondrosarcoma. This is the first case report of a primary renal spindle cell neoplasm of uncertain malignant potential with a HEY1::NCOA2 fusion identified by Fusionplex RNA‐sequencing that is histologically distinct from mesenchymal chondrosarcoma. The neoplasm was identified in a 33‐year‐old woman without significant past medical history who underwent partial nephrectomy for an incidentally discovered renal mass. The histologic features of the mass included spindle cells with variable cellularity and monotonous bland cytology forming vague fascicles and storiform architecture within a myxoedematous and collagenous stroma with areas of calcification. The morphologic and immunophenotypic features were not specific for any entity but were most similar to low‐grade fibromyxoid sarcoma. To date, the patient has not had recurrence, and the malignant potential of the neoplasm is uncertain.

Palmitic acid activates GPRs/KLF7/HEY1 signal axis to promote the occurrence and development of endometrial carcinoma

“…It has been con rmed that the abnormal expression of HEY1 is closely related to the occurrence, metastasis and prognosis of many kinds of tumors, and is expected to become an indicator of poor clinical prognosis, such as pancreatic cancer, colorectal cancer, esophageal cancer and thyroid cancer. 31,32,[44][45][46] In addition, a study by IsoT et al found that HEY1, as a transcriptional suppressor, can directly bind to E-Box inhibiting the expression of E-Cadherin, and promoting the occurrence of EMT. 47 In the present study, we found for the rst time that KLF7 can promote tumorigenesis through targeted regulation of HEY1/E-Cadherin pathway in endometrial cancer.…”