Novel low-shrinkage-stress bioactive nanocomposite with anti-biofilm and remineralization capabilities to inhibit caries

Filemban, Hanan; Bhadila, Ghalia; Wang, Xiaohong; Melo, Mary Anne S.; Oates, Thomas W.; Weir, Michael D.; Sun, Jirun; Xu, Hockin H.K.

doi:10.1016/j.jds.2021.09.032

Cited by 8 publications

(9 citation statements)

References 47 publications

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“…The lactate production was measured using a lactate dehydrogenase enzymatic method with the Lactic Acid Assay Kit (Nanjing Jiancheng Bio Engineering Institute, China) involving measuring OD340 nm, as previously reported. 38 The experiment involved using two samples from each group, and was repeated three times ( n = 6).…”

Section: Methodsmentioning

confidence: 99%

A low-shrinkage-stress and anti-bacterial adherent dental resin composite: physicochemical properties and biocompatibility

He,

Zhang,

Zhong

et al. 2024

J. Mater. Chem. B

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Section: Methodsmentioning

confidence: 99%

A low-shrinkage-stress and anti-bacterial adherent dental resin composite: physicochemical properties and biocompatibility

He,

Zhang,

Zhong

et al. 2024

J. Mater. Chem. B

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“…The researchers developed a hydrolytically stable low-shrinkage-stress polymer containing UDMA and TEG-DVBE (U1V1). It was mixed with dimethylaminododecyl methacrylate monomer (DMAHDM)-with a carbon chain length of 16, which is a highly effective, contact-killing, long-lasting antibacterial material [110][111][112][113][114]. Moreover, adding bioactive nanoparticles of amorphous calcium phosphate (NACP) was advantageous to dental tissues to regenerate the lost minerals and buffer the acidic environment by releasing calcium and phosphate ions to the enamel and dentin under low pH conditions [110][111][112][113][114].…”

Section: Using Hydrolytically Stable Monomers With Antibacterial and ...mentioning

confidence: 99%

“…Another study conducted by Filemban et al concluded that the novel resin composite reduced the stress without compromising other properties, Figure 4. Increasing the DMAHDM content increased the antibacterial effect in a dose-dependent manner [114]. In a study conducted by Albeshir et al, they formulated a novel flowable composite for minimally invasive treatment usages.…”

Section: Using Hydrolytically Stable Monomers With Antibacterial and ...mentioning

confidence: 99%

“…Biofilm metabolic activity was also substantially reduced compared to the control composite (p < 0.05). The novel bioactive flowable nanocomposite is promising to be used as pit and fissure sealants and as fillings in conservative cavities to inhibit recurrent caries and increase restoration Experimental control resin composite: 35% BT + 65% glass (denoted as BT control), Orange curve: 35% BT + 0% DMAHDM + 20% NACP + 45% glass (denoted as BT + 0%DMAHDM + NACP), Gray curve: 30% BT + 5% DMAHDM + 20% NACP + 45% glass (denoted as BT + 5% DMAHDM + NACP), Yellow curve: Experimental control resin composite: 35% UV + 65% glass (denoted as UV control), Light blue curve: 35% UV + 0% DMAHDM + 20% NACP + 45% glass (denoted as UV + 0% DMAHDM + NACP), Green curve: 30% UV + 5% DMAHDM + 20% NACP + 45% glass (denoted as UV + 5% DMAHDM + NACP)), Adapted with permission from reference [114]. Copyright 2021 Elsevier.…”

Section: Using Hydrolytically Stable Monomers With Antibacterial and ...mentioning

confidence: 99%

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Low-Shrinkage Resin Matrices in Restorative Dentistry-Narrative Review

et al. 2022

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Dimethacrylate-based resin composites restorations have become widely-used intraoral materials in daily dental practice. The increasing use of composites has greatly enhanced modern preventive and conservative dentistry. They have many superior features, especially esthetic properties, bondability, and elimination of mercury and galvanic currents. However, polymeric materials are highly susceptible to polymerization shrinkage and stresses that lead to microleakage, biofilm formation, secondary caries, and restoration loss. Several techniques have been investigated to minimize the side effects of these shrinkage stresses. The primary approach is through fabrications and modification of the resin matrices. Therefore, this review article focuses on the methods for testing the shrinkage, as well as formulations of resinous matrices available to reduce polymerization shrinkage and its associated stress. Furthermore, this article reviews recent cutting-edge developments on bioactive low-shrinkage-stress nanocomposites to effectively inhibit the growth and activities of cariogenic pathogens and enhance the remineralization process.

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“…Improving the longevity of dental restorations is a main goal in the dental material field; developing a bioactive LSS resin composite could enhance the marginal seal and prevent secondary caries [30][31][32]. Previously, it was shown that the sealing ability was enhanced with a low shrinkage-stress composite, which may inhibit secondary caries [31].…”

Section: Introductionmentioning

confidence: 99%

Novel Dental Low-Shrinkage-Stress Composite with Antibacterial Dimethylaminododecyl Methacrylate Monomer

Alhussein

AlSahafi

Wang

et al. 2023

JFB

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Objectives: Current dental resins exhibit polymerization shrinkage causing microleakage, which has the potential to cause recurrent caries. Our objectives were to create and characterize low-shrinkage-stress (LSS) composites with dimethylaminododecyl methacrylate (DMADDM) as an antibacterial agent to combat recurrent caries. Methods: Triethylene glycol divinylbenzyl ether and urethane dimethacrylate were used to reduce shrinkage stress. DMADDM was incorporated at different mass fractions (0%, 1.5%, 3%, and 5%). Flexural strength, elastic modulus, degree of conversion, polymerization stress, and antimicrobial activity were assessed. Results: The composite with 5% DMADDM demonstrated higher flexural strength than the commercial group (p < 0.05). The addition of DMADDM in BisGMA-TEGDMA resin and LSS resin achieved clinically acceptable degrees of conversion. However, LSS composites exhibited much lower polymerization shrinkage stress than BisGMA-TEGDMA composite groups (p < 0.05). The addition of 3% and 5% DMADDM showed a 6-log reduction in Streptococcus mutans (S. mutans) biofilm CFUs compared to commercial control (p < 0.001). Biofilm biomass and lactic acid were also substantially decreased via DMADDM (p < 0.05). Conclusions: The novel LSS dental composite containing 3% DMADDM demonstrated potent antibacterial action against S. mutans biofilms and much lower polymerization shrinkage-stress, while maintaining excellent mechanical characteristics. The new composite is promising for dental applications to prevent secondary caries and increase restoration longevity.

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Novel low-shrinkage-stress bioactive nanocomposite with anti-biofilm and remineralization capabilities to inhibit caries

Cited by 8 publications

References 47 publications

A low-shrinkage-stress and anti-bacterial adherent dental resin composite: physicochemical properties and biocompatibility

A low-shrinkage-stress and anti-bacterial adherent dental resin composite: physicochemical properties and biocompatibility

Low-Shrinkage Resin Matrices in Restorative Dentistry-Narrative Review

Novel Dental Low-Shrinkage-Stress Composite with Antibacterial Dimethylaminododecyl Methacrylate Monomer

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