Novel Macrolide from Wild Strains of the Phytopathogen Fungus <i>Colletotrichum Acutatum</i>

Mancilla, Gabriela; Jimenez‐Teja, Daniel; Femenia‐Rios, Marienca; Macı́as-Sánchez, Antonio J.; Collado, Isidro G.; Hernández-Galán, Rosario

doi:10.1177/1934578x0900400316

Cited by 9 publications

(7 citation statements)

References 18 publications

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“…monocillins I-III, monoorden, colletodiol, etc.) with phytotoxic and antimicrobial activities including novel macrolides produced by CAsc [ 93 – 96 ] . DMATS are overrepresented in Colletotrichum spp.…”

Section: Discussionmentioning

confidence: 99%

Gene family expansions and contractions are associated with host range in plant pathogens of the genus Colletotrichum

et al. 2016

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BackgroundMany species belonging to the genus Colletotrichum cause anthracnose disease on a wide range of plant species. In addition to their economic impact, the genus Colletotrichum is a useful model for the study of the evolution of host specificity, speciation and reproductive behaviors. Genome projects of Colletotrichum species have already opened a new era for studying the evolution of pathogenesis in fungi.ResultsWe sequenced and annotated the genomes of four strains in the Colletotrichum acutatum species complex (CAsc), a clade of broad host range pathogens within the genus. The four CAsc proteomes and secretomes along with those representing an additional 13 species (six Colletotrichum spp. and seven other Sordariomycetes) were classified into protein families using a variety of tools. Hierarchical clustering of gene family and functional domain assignments, and phylogenetic analyses revealed lineage specific losses of carbohydrate-active enzymes (CAZymes) and proteases encoding genes in Colletotrichum species that have narrow host range as well as duplications of these families in the CAsc. We also found a lineage specific expansion of necrosis and ethylene-inducing peptide 1 (Nep1)-like protein (NLPs) families within the CAsc.ConclusionsThis study illustrates the plasticity of Colletotrichum genomes, and shows that major changes in host range are associated with relatively recent changes in gene content.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-2917-6) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Gene family expansions and contractions are associated with host range in plant pathogens of the genus Colletotrichum

et al. 2016

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“…The synthesis of phenolic and flavonoidic antibiosis was early in all cultivars and organs. This very rapid accumulation of these constituents could be explained by their involvement in plant defense mechanisms (Broeckling et al, 2005;Suzuki et al, 2005;Naoumkina et al, 2007;Farag et al, 2009;Mancilla et al, 2009). Concerning flavonoids in particular, Chen et al (2007), Crawford et al (2004) and Calatayud et al (2011) found that resistance of cultivars of Carmellia oleifera and Lupinus angustifolius correlated with rapid and intense flavonoid production.…”

Section: Discussionmentioning

confidence: 98%

Physiological mechanism of resistance antibiosis to anthracnose of different Manihot varieties

Brou¹,

Moroh²,

Diabaté³

et al. 2020

Int. J. Bio. Chem. Sci

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Cassava is one of the main food crops in Africa, particularly in Côte d'Ivoire. However, the cultivated varieties are prone to attack by diseases. The present work focused on the role of phenolic and in particular flavonoid resistance markers in the Manihot esculenta-Colletotrichum gloeosporioides pathosystem. The aim was to elucidate the involvement of flavonoid antibiosis in the natural defense of three cultivars of M. esculenta when confronted with attacks by C. gloeosporioides. The quantitative dosage approach for total phenolics and flavonoids as well as the identification of flavonoid antibiosis have been carried out. The results revealed that the cultivars 9620A, TMS30572 and YACE of M. esculenta have, after the C. gloeosporioides inoculation tests, reacted early 2 days after inoculation (JAI) and accumulated relatively high levels of antibiosis phenolic and flavonoid 9JAI. The three cultivars accumulated constitutive flavonoid antibiosis and 3 neosynthesized antibiosis from 7JAI to 9JAI. The accumulation of flavonoid antibacterials neosynthesized in the stems and in the leaves testify to the expression of a systemic resistance of the cassava plants. The cultivars 9620A and TMS30572 are more tolerant than cultivar YACE. This study approach has made it possible to discriminate between cultivars and can therefore be used as a complementary selection tool to traditional selection tests.Keywords: Manihot esculenta, anthracnose, flavonoïd antibisis, glyphosate.

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“…This is very interesting because it can improve the prospects of produce compounds such as antifouling agents or to fight against epizootics in aquaculture in the future (Zhou et al, 2014). derivatives, diaporthacol (27), which was isolated as a triacetate derivative (28) (Khamthong, et al, 2014), R-mevalonolactone (29) (Amagata et al, 1998), dothiorelone C (30) (Sommart et al, 2009), (4S, 7S, 13S) -4.7dihydroxy-1,3-tetradeca-1,5-dienolide (31) (Mancilla et al 2009), 4b-acetoxy-9b, 10b, 15a-trihydroxyprobotrydial (32) (Collado et al, 1995 and O-methyldihydrobotrydial (33) (Kimura et al, 1988) (Figure 7). The eighth these compounds were isolated from the marine-derived fungi Diaporthaceae sp.…”

Section: Sesquiterpenoidsmentioning

confidence: 99%

Potential Marine-Derived Fungi Isolated From Sponge in Produce New and Beneficial Compounds

Tanod¹,

Muliadin²,

Adel³

et al. 2020

KAUDERNI J. Fish. Mar. Aquat. Sci.

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Marine organisms are a source of natural products and produce compounds with a molecular structure that is unique and useful. Thousands of new compounds have biological activitity for anticancer, antiviral, and antimicrobial. This compounds isolated from various marine organism, including from marine-derived fungi. Investigation of chemical compounds from marine-derived fungi isolated from sponge has increased steadily, indicating the important role of marine-derived fungi in the discovery of drug compounds. The sponge has produced various kinds of fungi, which have reported to provide a variety of pharmacologically active metabolites and structurally diverse. Study literature showed that many fungal genera isolated from the marine sponge dominated the genus Acremonium, Aspergillus, Penicillium, Phoma, and Fusarium. The high proportion of genera and new compounds showed that the fungi isolated from the sponge could develop.

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Novel Macrolide from Wild Strains of the Phytopathogen Fungus Colletotrichum Acutatum

Abstract: Three wild strains of C. acutatum have been investigated for their phytotoxic secondary metabolites involved in anthracnose disease. In addition to known compounds, a new macrolide 6 has been isolated and characterized by spectroscopic analysis.

Cited by 9 publications

References 18 publications

Gene family expansions and contractions are associated with host range in plant pathogens of the genus Colletotrichum

Gene family expansions and contractions are associated with host range in plant pathogens of the genus Colletotrichum

Physiological mechanism of resistance antibiosis to anthracnose of different Manihot varieties

Potential Marine-Derived Fungi Isolated From Sponge in Produce New and Beneficial Compounds

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