Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase

Genome mining and biosynthesis of fumitremorgin-type alkaloids in ascomycetes

“…All of these compounds were isolated from several fungal strains. [5][6][7] Some of these substances have been found to show interesting biological and pharmacological activities. For example, 2 and 3 as well as their diastereomeres were found to exhibit cytotoxicity toward various cancer cell lines, even more potent than etoposide.…”

Diastereoselective Hydrogenation in the Preparation of Fine Chemicals

“…A large number of natural diketopiperazines contain a proline structure and the biological activity of this class of diketopiperazines varies considerably [47][48][49][50][51]. Our study of the diastereoselective hydrogenation of pyrazine derivatives [24], which is discussed in Section 2.5, revealed the stereoselective formation of a new diketopiperazine derivative (1d, figure 1).…”

tert-Butyl (2S,3R,4R)-7′-bromo-4-methyl-2′,5-dioxo-4,5-dihydro-3H-spiro[furan-2,3′-indoline]-3-carboxylate

“…Spirocyclic oxindoles are important structures in many biologically active molecules and natural products (Cui et al, 1996). The key structural characteristic of these compounds is the spiro ring fused at the 3-position of the oxindole core (Cerisoli et al, 2016) with varying degrees of substitution around it (Trost & Brennan, 2009;Wang et al, 2013;Monari et al, 2015).…”