Novel markers of normal and neoplastic human plasmacytoid dendritic cells

Marafioti, Teresa; Paterson, Jennifer C.; Ballabio, Erica; Reichard, Kaaren K.; Tedoldi, Sara; Hollowood, Kevin; Dictor, Michael; Hansmann, Martin Leo; Pileri, Stefano; Dyer, Martin J. S.; Sozzani, Silvano; Đikić, Ivan; Shaw, Andréy S.; Petrella, Tony; Stein, Harald; Isaacson, Peter G.; Facchetti, Fabio; Mason, David Y.

doi:10.1182/blood-2007-10-117531

Cited by 202 publications

(185 citation statements)

References 127 publications

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“…The neoplastic cells are typically dim CD45 positive and may be TdT positive, compatible with blastic, immature cells (4,10,11). Although TdT expression is more commonly seen in precursor lymphoid neoplasms, in contrast to lymphoblastic leukemias, BPDCN will not exhibit lineage-specific markers such as CD3, CD19, CD79a, or cytoplasmic CD22, although expression of the T-cell associated antigens CD2 and CD7 has been reported (2).…”

Section: Discussionmentioning

confidence: 99%

“…Given that the neoplastic cells lack lineage-specific myeloid, B, or T-cell antigens, extensive immunophenotypic characterization must be employed to establish the diagnosis. The emergence of more specific PDC markers such as CD123 has made it possible to identify the PDC origin of BPDCN (10).…”

Section: Discussionmentioning

confidence: 99%

“…CD123 is a robust PDC marker which has been extensively studied in prior flow cytometric studies, however, may also be seen in other hematologic malignancies such as AML, lymphoblastic leukemias, and hairy cell leukemias (13,14). Additional immunohistochemical antibodies for use in tissue sections have become available to help identify PDC origin, including TCL1, BDCA-2, and CD2AP (10,15,16). These studies may be useful to correlate with the results of the flow cytometric analysis.…”

Section: Discussionmentioning

confidence: 99%

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Case study interpretation—New Orleans: Case 5

Roth

Robinson

2013

Cytometry Part B Clinical

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CASE HISTORYThe patient is an 81-year-old gentleman who was referred to the hematology/oncology service for worsening fatigue and skin lesions. His past medical history is significant for myelodysplastic syndrome diagnosed 5 months ago. He was symptomatically treated and followed a relatively stable course until approximately 1 month ago. At that time, he noticed multiple skin lesions over his trunk and legs, and also became increasingly fatigued with exertional dyspnea, finding himself short of breath after climbing one flight of stairs. Laboratory data were significant for 30% circulating blasts, neutropenia (ANC ¼ 0.96/mm 3 ), macrocytic anemia (Hgb 7.7 g/dL, MCV 109.6), and thrombocytopenia (52 Â

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Case study interpretation—New Orleans: Case 5

Roth

Robinson

2013

Cytometry Part B Clinical

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“…Th e plans are to continue his chemotherapy regimen with an eventual allogeneic bone marrow transplant. dendritic cells (2)(3)(4). Th is entity has been known under various names including agranular CD4 + natural killer (NK) cell leukemia, blastic NK-cell lymphoma, blastic NK leukemia, and agranular CD4 + , CD56 + hematodermic neoplasm.…”

Section: Case Reportmentioning

confidence: 99%

Blastic Plasmacytoid Dendritic Cell Neoplasm Following Acquired Erythropoietic Protoporphyria

Krause¹,

Baugh²,

Swink³

et al. 2017

Baylor University Medical Center Proceedings

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“…Low-level bone-marrow involvement is often seen at presentation or soon after [1,4,6,7]. Immunohistochemistry and flow cytometric analysis are essential tools for making the diagnosis and for evaluating new markers of disease; in particular, the adaptor protein CD2AP [8], BDCA-2 (CD303), and BDCA-4 (CD304) [1] were recently identified. Lymphadenopathy or splenomegaly or both are frequent.…”

Section: Diagnosis and Clinical Presentationmentioning

confidence: 99%

Plasmacytoid Dendritic Cell Leukemia: A Rapidly Evolving Disease Presenting with Skin Lesions Sensitive to Radiotherapy plus Hyperthermia

et al. 2009

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Plasmacytoid dendritic cell leukemia (pDCL) is a rapidly evolving disease, which frequently presents with skin lesions, particularly nodules and plaques with a typical reddish-brown or brown color. Treatment of pDCL is based on multiagent chemotherapy followed by allogeneic hematopoietic stem cell transplant, but skin lesions may be refractory to therapy. Here, we report on a 61-year-old patient affected by pDCL who first presented with multiple cutaneous nodules and plaques on the trunk. Lesions showed an excellent response to radiotherapy plus hyperthermia. Although this treatment did not avoid the systemic evolution of disease, it resolved skin lesions and prevented their relapse, thus representing a therapeutic option to be used in combination with chemotherapy regimens. The case presentation is followed by a general discussion with an emphasis on the diagnosis and treatment of this rare malignancy. The Oncologist 2009;14:1205-1208 CASE PRESENTATIONA 61-year-old white man was referred with a diagnosis of acute monocytic leukemia cutis manifesting with a 3-month history of skin nodules. The patient presented with reddishbrown or brown multiple skin nodules and plaques up to 5 cm in diameter on the trunk and neck. Brown macules were also present on the upper trunk. Lesions were moderately itchy and painful. He had no systemic symptoms. Physical examination revealed axillary lymphadenopathies. Routine blood tests and a peripheral blood smear were negative. The bone marrow aspirate showed low-level involvement (20%) by medium/large-sized agranular blast cells present-

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Novel markers of normal and neoplastic human plasmacytoid dendritic cells

Cited by 202 publications

References 127 publications

Case study interpretation—New Orleans: Case 5

Case study interpretation—New Orleans: Case 5

Blastic Plasmacytoid Dendritic Cell Neoplasm Following Acquired Erythropoietic Protoporphyria

Plasmacytoid Dendritic Cell Leukemia: A Rapidly Evolving Disease Presenting with Skin Lesions Sensitive to Radiotherapy plus Hyperthermia

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