Novel mechanosensory role for acid sensing ion channel subtype 1a in evoking the exercise pressor reflex in rats with heart failure

Butenas, Alec L.; Rollins, Korynne S.; Parr, Shannon K.; Hammond, Stephen T.; Ade, Carl J.; Hageman, K. Sue; Musch, Timothy I.; Copp, Steven W.

doi:10.1113/jp282923

Cited by 7 publications

(3 citation statements)

References 86 publications

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“…It is one of the major causes of mortality and mobility worldwide ( Tomasoni et al, 2019 ; Sinnenberg & Givertz, 2020 ; McDonagh et al, 2021 ). Patients with HF experience impaired tolerance for even mild exercise, exacerbated fatigue, and elevated cardiovascular risk most likely because they have an exacerbated EPR ( Butenas et al, 2022 ).…”

Section: Asic Channels In the Cardiac Afferent Innervationmentioning

confidence: 99%

“…All three ASIC subunits expressed in afferent endings innervating skeletal muscle, 1a, 2a and 3, are mediating the signaling of the metabolic component of the EPR ( Gibbons et al, 2015 ; Ducrocq et al, 2019 ; Li et al, 2023 ). Recently, ASIC1a was found to participate in the mechanical component of EPR in HF animals but not in healthy animals ( Butenas et al, 2022 ). Taken together, this information suggests that ASIC-targeted strategies may have relevant clinical implications for patients with HF.…”

Section: Asic Channels In the Cardiac Afferent Innervationmentioning

confidence: 99%

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The role of acid sensing ion channels in the cardiovascular function

López-Ramírez¹,

González-Garrido

2023

Front. Physiol.

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Acid Sensing Ion Channels (ASIC) are proton sensors involved in several physiological and pathophysiological functions including synaptic plasticity, sensory systems and nociception. ASIC channels have been ubiquitously localized in neurons and play a role in their excitability. Information about ASIC channels in cardiomyocyte function is limited. Evidence indicates that ASIC subunits are expressed in both, plasma membrane and intracellular compartments of mammalian cardiomyocytes, suggesting unrevealing functions in the cardiomyocyte physiology. ASIC channels are expressed in neurons of the peripheral nervous system including the nodose and dorsal root ganglia (DRG), both innervating the heart, where they play a dual role as mechanosensors and chemosensors. In baroreceptor neurons from nodose ganglia, mechanosensation is directly associated with ASIC2a channels for detection of changes in arterial pressure. ASIC channels expressed in DRG neurons have several roles in the cardiovascular function. First, ASIC2a/3 channel has been proposed as the molecular sensor of cardiac ischemic pain for its pH range activation, kinetics and the sustained current. Second, ASIC1a seems to have a critical role in ischemia-induced injury. And third, ASIC1a, 2 and 3 are part of the metabolic component of the exercise pressure reflex (EPR). This review consists of a summary of several reports about the role of ASIC channels in the cardiovascular system and its innervation.

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Section: Asic Channels In the Cardiac Afferent Innervationmentioning

confidence: 99%

Section: Asic Channels In the Cardiac Afferent Innervationmentioning

confidence: 99%

The role of acid sensing ion channels in the cardiovascular function

López-Ramírez¹,

González-Garrido

2023

Front. Physiol.

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“…Studies are carried out until the skill is fully formed in all control broods. [6] Tests to examine sensorimotor disorders in adult animals: To examine the degree of sensorimotor disorders in adult rats, a variety of methods are employed: the Bederson test, the modified neurological deficit depth test, the Garcia test, the angle test, the paw stretch test, the open field test.…”

Section: Introductionmentioning

confidence: 99%

Neurological Deficit Methodical Approaches to Experimental Study

Maksimovich,

Lizaveta,

Vishnevskaya

et al. 2023

JCRCT

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Freasibility of studying pathology of the brain in the experiment leeds to the need for adequate ways to assess the neurological deficit that occurs in animals, including sensorimotor and behavioral disorders, as well as disorders of higher nervous activity (memory, gnosis, praxis, emotional behavior, etc.). The rat is one of the adequate objects of experimental research to study brain disorders in various pathologies. The review summarizes the literature data on possible ways to evaluate sensory-motor reflexes, learning ability and memory in experimental animals at different ages. In the early postnatal period, reflexes are evaluated: "flipping on the plane", "negative geotaxis", "avoidance of breakage", "acoustic stimulus response", "olfactory reaction" and "muscle strength". To study the degree of neurological and behavioral disorders in adult animals, a number of methods can be used: the Bederson test, the test for evaluating modified indicators of the depth of neurological deficit, the Garcia test, the angular test, the paw pulling test, the "open field" test.

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