Novel mefenamic acid PVC membrane sensor based on a new Cd Schiff's base complex containing a phenanthroline unit

Abstract

and can be applied for at least 5 months without any significant divergence in the currents.

Sericin-Based Bio-Inspired Nano-Engineering of Heterometallic AgAu Nanocubes for Attomolar Mefenamic Acid Sensing in the Mobile Phone-Based Surface Plasmon-Coupled Interface

“…In general, although pharmaceuticals are used to support the growth of livestock and in the prevention of diseases, the never-ending eco-toxicological effects observed on account of their extensive usage have recently turned out to be a perpetual threat to the ecosystem . Mefenamic acid is a fenamate class of non-steroidal anti-inflammatory (as well as analgesic, antipyretic) drugs that are generally administered to adults for the short-term treatment of many pathological conditions such as menstrual pain, osteoarthritis, muscle pain, tooth and headaches, musculoskeletal disorders, non-articular rheumatism post-surgical pain, and fever. − The pharmacological functionality of mefenamic acid is on account of its influence on cyclooxygenase (COX) pathways. This is also reported to cause an imbalance in the sex hormone production (effecting reproduction) and act as an endocrine disrupter. − Unregulated concentrations of mefenamic acid do not have any specific antidotes and include symptoms such as lethargy, drowsiness, nausea, hypertension, acute renal failure, respiratory depression, hepatic necrosis, vomiting, intestinal ulcers, colitis, epigastric pain, and gastrointestinal bleeding on account of accumulation of toxic metabolites in the human body. − Furthermore, in addition to the harmful effects generated in the human body, this pharmaceutical drug is reported to be extremely hazardous to the endocrine system in wildlife as well as aquatic ecosystem, where they are frequently detected .…”

“…This high enhancement in fluorescence was utilized for attomolar detection of biologically relevant mefenamic acid [chemical name: 2-[(2,3-dimethlyphenyl) amino]­benzoic acid; N -(2,3-xyly) anthranilic acid], taking into consideration its close interaction with rhodamine B-radiating dipoles . On account of its harmful effects and need for early monitoring in biological and environmental samples, different methods including spectrophotometry, chromatography, potentiometry, chemiluminescence, capillary zone electrophoresis titration, spectrofluorimetry, electrochemical analysis, atomic absorption spectrometry, nuclear magnetic resonance spectroscopy, and flow injection analysis have been developed for the determination of trace levels of this non-steroidal anti-inflammatory drug, which is listed as a chemical pollutant. − …”

Determination of mefenamic acid in aqueous solutions using merging zone – continuous flow injection

“…For future developments, new sensors could be integrated into this technique, such as electromagnetic sensors nanosensors (Shojaei et al 2016;Ryecroft et al 2019Ryecroft et al , 2021Mohammadian et al 2022) or membrane sensors (Babakhanian 2012;Noroozi & Keypour 2017).…”

Long-Term Stability Monitoring of Printed Proteins on Paper-Based Membranes

“…20,21 Colorimetric/immunosensing platforms are widely used in various viruses, antigens, and pollutant detection systems; however, most of the studies of these paper-based sensors focus on detection sensitivity and not stability or storage conditions. 22−24 In addition, a large number of paper-based sensing membrane systems have adopted chemically treated membranes to enhance protein/antibody adsorption and stability, 25−27 but comparative studies of protein stability and detection sensitivity on different paper-based membranes are rare. To verify the stability of printed proteins on paper-based membranes and to fill the gaps in research, we conducted systematic studies of protein stability and sensitivity on three different paper-based membranes.…”

“…Detection and sensing of viruses, pollutants, and other related proteins have received much attention with the Zika and MERS outbursts in recent years. − To be considered a good detection and sensing platform, stability and detection sensitivity as well as ease of use and maintenance should be guaranteed. , There are several careful studies of paper-based sensing membranes that provide a cheap and convenient option for virus/pollutant detection. − To date, a large number of novel paper-based sensing technologies, including nanoparticle-based and electronic-based sensors, have been developed to increase detection sensitivity. − However, many of these technologies require a significant amount of detection time, function only under certain storage conditions and are quite often expensive. As alternatives to these high technology sensing platforms, colorimetric and immunosensors are still popular in clinical use. − These immunosensors are based on immobilized capturing antibodies, and virus particles/antigens captured on antibodies were detected by detection antibodies. , Colorimetric/immunosensing platforms are widely used in various viruses, antigens, and pollutant detection systems; however, most of the studies of these paper-based sensors focus on detection sensitivity and not stability or storage conditions. − In addition, a large number of paper-based sensing membrane systems have adopted chemically treated membranes to enhance protein/antibody adsorption and stability, − but comparative studies of protein stability and detection sensitivity on different paper-based membranes are rare. To verify the stability of printed proteins on paper-based membranes and to fill the gaps in research, we conducted systematic studies of protein stability and sensitivity on three different paper-based membranes.…”