Novel method for early signs of clinical shock detection by monitoring blood capillary/vessel spatial pattern

Kanawade, Rajesh; Klämpfl, Florian; Riemann, Max; Knipfer, Christian; Tangermann-Gerk, Katja; Schmidt, Michael; Stelzle, Florian

doi:10.1002/jbio.201300065

Cited by 9 publications

(8 citation statements)

References 35 publications

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“…The observation of the human capillary structure by means of DRS/DRI has already been reported in the literature-however, the dimensions of the capillary structures underlying these studies are significantly different from anatomically correct values 10,11 . The present study is therefore intended to investigate whether it is possible to detect capillary structures of realistic size and shape (diameter: 10 µm , length: 50 µm 12 , loop shape) employing our self-developed method of shifted position-diffuse reflectance imaging (SP-DRI), which is presented here for the first time.…”

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confidence: 89%

Towards shifted position-diffuse reflectance imaging of anatomically correctly scaled human microvasculature

Späth

Hohmann

Roider

et al. 2020

Sci Rep

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Due to significant advantages, the trend in the field of medical technology is moving towards minimally or even non-invasive examination methods. In this respect, optical methods offer inherent benefits, as does diffuse reflectance imaging (DRI). The present study attempts to prove the suitability of DRI—when implemented alongside a suitable setup and data evaluation algorithm—to derive information from anatomically correctly scaled human capillaries (diameter: $$10\,\upmu \hbox {m}$$ 10 μ m , length: $$45\,\upmu \hbox {m}$$ 45 μ m ) by conducting extensive Monte–Carlo simulations and by verifying the findings through laboratory experiments. As a result, the method of shifted position-diffuse reflectance imaging (SP-DRI) is established by which average signal modulations of up to 5% could be generated with an illumination wavelength of $$\lambda =424\,\hbox {nm}$$ λ = 424 nm and a core diameter of the illumination fiber of $$50\,\upmu \hbox {m}$$ 50 μ m . No reference image is needed for this technique. The present study reveals that the diffuse reflectance data in combination with the SP-DRI normalization are suitable to localize human capillaries within turbid media.

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confidence: 89%

Towards shifted position-diffuse reflectance imaging of anatomically correctly scaled human microvasculature

Späth

Hohmann

Roider

et al. 2020

Sci Rep

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“…The diameter (3.5-6 μm), length (23.3-270 μm) and width (32-46.1 μm) of the capillary loop were 4.75 μm, 42 μm and 45 μm, respectively [25]. The capillary loop was positioned at a depth of 150 μm from the skin surface [26].…”

Section: ) Cutaneous Capillariesmentioning

confidence: 99%

Millimeter-Wave Induced Heating of Cutaneous Nerves and Capillaries

et al. 2023

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In this study, we quantify microscale heating at the level of cutaneous nerves and capillaries due to continuous and pulsed plane-wave exposure at 60 GHz. The thermal properties of the nerves and capillaries were derived using mixture equations based on their water content. The electromagnetic problem was solved in conjunction with Pennes bioheat equation and Arrhenius equation using finite element method to evaluate the spatial and temporal evolution of temperature along with thermal damage within cutaneous nerves and capillaries. Although, the maximum power density within the nerve (41.6 kW/m 3 ) and capillary (20 kW/m 3 ) was 37.3% and 30.2% higher than surrounding skin for a continuous exposure at 10 W/m 2 , the peak temperature elevation ( T ) within the nerve (93.3 n°C) and capillary (90.7 n°C) occurred after 5 μs and 10 μs of exposure and was 19.2% and 17.7% higher than surrounding skin, respectively. The nerve and capillary attained thermal equilibrium with skin after roughly 10 ms. The maximal T within the nerve (0.5 °C) and capillary (0.25 °C) due to nano-and micro-second 60 GHz pulses with highest fluence (0.48 kJ/m 2 ) permitted under ICNIRP guidelines was 34% and 24% higher than in the surrounding skin. Ten 3 μs 60 GHz pulses (power density = 13.4 GW/m 2 ) separated by 10 s of cooling period were used to demonstrate the possibility of selective thermal ablation of cutaneous nerves [damage index (Ω)=1.1)] without damaging skin (Ω = 0.15). The results provide valuable insights into local millimeter-wave induced heating within various skin substructures.INDEX TERMS Finite element method, human skin, millimeter waves, thermal dosimetry.This article has been accepted for inclusion in a future issue of this journal. Content is final as presented, with the exception of pagination. This article has been accepted for inclusion in a future issue of this journal. Content is final as presented, with the exception of pagination.

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“…The data processing method used for the reduced-/oxyhemoglobin concentration and oxygen saturation determinations is explained elsewhere. 16,27,28 Taylor series expansion is used to Please do not adjust margins Please do not adjust margins build three equations from the measured diffuse reflectance spectra for three adjacent wavelengths λ 0 , λ 1 , and λ 2. 16,27,28 (1)…”

Section: Blood Oxygenation Calculationmentioning

confidence: 99%

“…16,27,28 Taylor series expansion is used to Please do not adjust margins Please do not adjust margins build three equations from the measured diffuse reflectance spectra for three adjacent wavelengths λ 0 , λ 1 , and λ 2. 16,27,28 (1)…”

Section: Blood Oxygenation Calculationmentioning

confidence: 99%

“…25,26 The applicability of DRS techniques to detect real-time oxygenation changes associated with tissue and blood vessel spatial patterns for early clinical shock detection has been reported elsewhere. 27 Thus, considering the above advantages, the aim of the study is to prove the applicability of DRS to monitoring localized blood oxygenation parameters from the fingertips of male and female healthy subjects of various age groups. Effort was focused on improving the accuracy of the real-time reduced hemoglobin, oxyhemoglobin, and oxygen saturation monitoring techniques for intensive care units and for emergency & rescue teams.…”

Section: Introductionmentioning

confidence: 99%

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Diffuse reflectance-based spectroscopic technique for real-time estimation of localized blood oxygenation parameters from human fingertips: a preliminary study

et al. 2022

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Novel method for early signs of clinical shock detection by monitoring blood capillary/vessel spatial pattern

Cited by 9 publications

References 35 publications

Towards shifted position-diffuse reflectance imaging of anatomically correctly scaled human microvasculature

Towards shifted position-diffuse reflectance imaging of anatomically correctly scaled human microvasculature

Millimeter-Wave Induced Heating of Cutaneous Nerves and Capillaries

Diffuse reflectance-based spectroscopic technique for real-time estimation of localized blood oxygenation parameters from human fingertips: a preliminary study

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