Novel methods for the quantification of toxic, residual phase transfer catalyst in fluorine-18 labeled radiotracers

Blevins, David W.; Rigney, Grant H.; Fang, Michael; Akula, Murthy R.; Osborne, Dustin

doi:10.1016/j.nucmedbio.2019.07.008

Cited by 11 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, when an antioxidant is present, these tests have been unable to produce a spot for TBA in our hands. Lastly, some new, quantitative methods for determining TBA have been proposed [6]. Of these methods, the spectrophotometric method seems to be the most promising, and would allow for unbiased and accurate determination of TBA, whilst producing analytical data that could be easily incorporated in electronic batch reports.…”

Section: Introductionmentioning

confidence: 99%

A Fast and Simple Method for the Determination of TBA in 18F-Labeled Radiopharmaceuticals

Halvorsen

Kvernenes

2020

Pharmaceuticals

View full text Add to dashboard Cite

A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various 18F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the 18F-radiopharmaceutical to be tested and TBA, then with deionized water or hydrogen peroxide (H2O2) solution, depending on if an antioxidant stabilizer is part of the pharmaceutical matrix. A distinct brown spot is visible at TBA concentrations of 50 µg/mL and up.

show abstract

Section: Introductionmentioning

confidence: 99%

A Fast and Simple Method for the Determination of TBA in 18F-Labeled Radiopharmaceuticals

Halvorsen

Kvernenes

2020

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…O LED RGB foi a opção mais viável para ser usada como fonte de luz e o luxímetro TSL2591 foi escolhido para detectar o fluxo luminoso. Ambos os componentes foram utilizados em trabalhos nas áreas médica e biomédica (BLEVINS et al, 2019;TEIKARI et al, 2012).…”

Section: Ensaios Realizados Nos Protótiposunclassified

Espectrofotômetro dedicado para dosagem de cloretos no suor

Saverio Spozito

View full text Add to dashboard Cite

show abstract

Faster detection method of 2.2.2 Kryptofix in radiopharmaceutical $$^{18}_{}{\text{F}}$$-FDG? Development and validation of analytical spot test

Krascsenits

Juračka

Galamboš

et al. 2023

J Radioanal Nucl Chem

View full text Add to dashboard Cite

Novel methods for the quantification of toxic, residual phase transfer catalyst in fluorine-18 labeled radiotracers

Cited by 11 publications

References 11 publications

A Fast and Simple Method for the Determination of TBA in 18F-Labeled Radiopharmaceuticals

A Fast and Simple Method for the Determination of TBA in 18F-Labeled Radiopharmaceuticals

Espectrofotômetro dedicado para dosagem de cloretos no suor

Faster detection method of 2.2.2 Kryptofix in radiopharmaceutical $$^{18}_{}{\text{F}}$$-FDG? Development and validation of analytical spot test

Contact Info

Product

Resources

About