Novel microemulsion-based gels for topical delivery of indomethacin: Formulation, physicochemical properties and in vitro drug release studies

Froelich, Anna; Osmałek, Tomasz; Snela, Agnieszka; Kunstman, Paweł; Jadach, Barbara; Olejniczak, Marta; Roszak, Grzegorz; Białas, W.

doi:10.1016/j.jcis.2017.08.011

Cited by 72 publications

(38 citation statements)

References 83 publications

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“…In other words, water, oil, and surfactant (or a combination of surfactants) are mixed to form a macroscopically homogeneous system from two or more immiscible compounds. In fact, because of its versatility [1,2], the technological application of emulsions is vast among industries that include food [3][4][5], pharmaceutics [6][7][8], and cosmetics [9][10][11]. Among the different types of emulsions, micro-and nanoemulsions present the most appealing properties due to their higher stability and possibility to serve as potential carriers of functionalities [12].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Optimization of Nanoemulsions Using the Natural Surfactant Saponin from Quillaja Bark

et al. 2020

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Replacing synthetic surfactants by natural alternatives when formulating nanoemulsions has gained attention as a sustainable approach. In this context, nanoemulsions based on sweet almond oil and stabilized by saponin from Quillaja bark with glycerol as cosurfactant were prepared by the high-pressure homogenization method. The effects of oil/water (O/W) ratio, total surfactant amount, and saponin/glycerol ratio on their stability were analyzed. The formation and stabilization of the oil-in-water nanoemulsions were analyzed through the evaluation of stability over time, pH, zeta potential, and particle size distribution analysis. Moreover, a design of experiments was performed to assess the most suitable composition based on particle size and stability parameters. The prepared nanoemulsions are, in general, highly stable over time, showing zeta potential values lower than −40 mV, a slight acid behavior due to the character of the components, and particle size (in volume) in the range of 1.1 to 4.3 µm. Response surface methodology revealed that formulations using an O/W ratio of 10/90 and 1.5 wt% surfactant resulted in lower particle sizes and zeta potential, presenting higher stability. The use of glycerol did not positively affect the formulations, which reinforces the suitability of preparing highly stable nanoemulsions based on natural surfactants such as saponins.

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Section: Introductionmentioning

confidence: 99%

Formulation and Optimization of Nanoemulsions Using the Natural Surfactant Saponin from Quillaja Bark

et al. 2020

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“…Generally, microemulsions (MEs) are composed of surfactant, water, oil, and alcohol. They have numerous advantages that have gained a lot of attention, especially, as potential carriers of effective compounds in drug delivery [1][2][3]. Since MEs are isotropic and thermodynamically stable oil-in-water (o/w) Article Related Abbreviations: AA, acrylamide; APS, ammonium persulfate; CA, cellulose acetate; HPC, hydroxypropyl cellulose; HPMC, hydroxypropyl methylcellulose; ME, microemulsion; MEEKC, microemulsion electrokinetic chromatography; MQ, ultrapure water; O/W, oil-in-water; PF, partial filling; STC, sodium salt of taurocholic acid.…”

Section: Introductionmentioning

confidence: 99%

Extraction of male steroids and progesterone from water by vegetable oil gels and their determination by partial filling capillary micellar electrokinetic chromatography

Sirén

Fellah

2019

J of Separation Science

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Microemulsion gels were synthetized from macadamia, linseed, olive, walnut, rapeseed, sesame, and coconut oils and frying oil made from sunflower, palm, and rapeseed oils. The gels were similar as polyacrylamide–based gels with exception of replacing dodecyl sulfate with vegetable oils. The gels were modified with celluloses, cotton, or lignin to make the emulsions sustainable for water purification. They were used to compare sorption properties when they were used as solid‐phase adsorbents in isolation of steroids from water. Hydrophobicity features of the gels were compared by detecting adsorption and extraction efficiency of nonpolar androstenedione, testosterone, and progesterone, which exist in wastewater and drinking water. Quantification was done with partial filling–micellar electrokinetic chromatography with 29.5 mM sodium dodecyl sulfate–3.4 mM sodium taurocholate as the micelle and 20 mM ammonium acetate (pH 9.68) as the electrolyte. UV‐detection was used. Methanol was the best eluent for extraction of steroids from gels. The highest recoveries were from frying oil and rapeseed oil gels modified with celluloses. They also possessed the best floating properties on water surface. Lignin modified gels were too hydrophilic, when in touch with water they filled up with water. They also had the lowest capacity.

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“…Considerable attention is devoted to the solution of this problem. For this purpose, micellar systems, microemulsions, solid lipid and polymeric particles have been explored [17][18][19][20][21]. However, there are still no optimal nanocontainers for indomethacin, which completely meet the requirements for drug delivery systems in living organisms, such as high loading degree, size of less than 200 nm, controlled release of drug, and low toxicity.…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte nanocontainers: Controlled binding and release of indomethacin

Mirgorodskaya

Kushnazarova

Nikitina

et al. 2018

Journal of Molecular Liquids

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Herein, polyelectrolyte capsules containing anti-inflammatory drug indomethacin were formed using layer-by-layer strategy, which involves alternative deposition of oppositely charged polyelectrolytes, such as poly(acrylic acid) and poly(ethyleneimine) (or chitosan) onto the drug substrate. Two variants of encapsulation have been implemented: direct deposition of polyelectrolytes onto indomethacin dispersed in water at рН 6, and preliminary formation of soft matrix by solubilization of indomethacin in micellar solutions of cationic surfactants. The inclusion of indomethacin into nanosized polyelectrolyte capsules (hydrodynamic diameter of three-and five-layer capsules is 90-180 nm) has given a new form of indomethacin with the drug content of 0.20-0.25%, which exceeds its limiting solubility in water nearly by the factor of 40. The choice of materials and procedures used for preparation of capsules, as well as the number of polyelectrolyte layers that form shell has provided the control of the drug release from capsule and resulted in the design of pharmaceutical dosage forms with long-lasting effect.

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Novel microemulsion-based gels for topical delivery of indomethacin: Formulation, physicochemical properties and in vitro drug release studies

Cited by 72 publications

References 83 publications

Formulation and Optimization of Nanoemulsions Using the Natural Surfactant Saponin from Quillaja Bark

Formulation and Optimization of Nanoemulsions Using the Natural Surfactant Saponin from Quillaja Bark

Extraction of male steroids and progesterone from water by vegetable oil gels and their determination by partial filling capillary micellar electrokinetic chromatography

Polyelectrolyte nanocontainers: Controlled binding and release of indomethacin

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