Novel microsphere-packing synthesis, microstructure, formation mechanism and in vitro biocompatibility of porous gelatin/hydroxyapatite microsphere scaffolds

Zhu, Yuhua; Chen, Song; Zhang, Cunfang; Ikoma, Toshiyuki; Guo, Hongmei; Zhang, Xinyan; Li, Xiaona; Chen, Weiyi

doi:10.1016/j.ceramint.2021.08.111

Cited by 29 publications

(14 citation statements)

References 32 publications

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“…In bone tissue engineering, numerous studies have been reported in which hydroxyapatite, bioglass, or silicate-like inorganics (as bioactive additives), and also collagen (as a supportive biopolymer) are incorporated into polymer matrices in order to promote osteogenic activity and to mimic bone tissue [ [84] , [92] , [93] , [94] , [95] , [96] ]. In addition to the successful results of those studies, our study here presents decellularized bone particles composed of both hydroxyapatite and collagen as a natural additive.…”

Section: Resultsmentioning

confidence: 99%

3D printed gelatin/decellularized bone composite scaffolds for bone tissue engineering: Fabrication, characterization and cytocompatibility study

Kara¹,

Distler²,

Polley³

et al. 2022

Materials Today Bio

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Section: Resultsmentioning

confidence: 99%

3D printed gelatin/decellularized bone composite scaffolds for bone tissue engineering: Fabrication, characterization and cytocompatibility study

Kara¹,

Distler²,

Polley³

et al. 2022

Materials Today Bio

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“…Therefore, it is particularly important to develop hydrogel dressings with a simple preparation process, good physical properties, and biological effects, using natural polymers. Gelatin-based hydrogels have been widely studied and applied in spite of their good biocompatibility and biodegradability [ 15 , 16 ]. However, due to the complex preparation process of gelatin-based hydrogels, its superior biological activity function cannot be better demonstrated.…”

Section: Introductionmentioning

confidence: 99%

A physicochemical double-cross-linked gelatin hydrogel with enhanced antibacterial and anti-inflammatory capabilities for improving wound healing

Zhao

et al. 2022

J Nanobiotechnol

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Background Skin tissue is vital in protecting the body from injuries and bacterial infections. Wound infection caused by bacterial colonization is one of the main factors hindering wound healing. Wound infection caused by colonization of a large number of bacteria can cause the wound to enter a continuous stage of inflammation, which delays wound healing. Hydrogel wound dressing is composed of natural and synthetic polymers, which can absorb tissue fluid, improve the local microenvironment of wound, and promote wound healing. However, in the preparation process of hydrogel, the complex preparation process and poor biological efficacy limit the application of hydrogel wound dressing in complex wound environment. Therefore, it is particularly important to develop and prepare hydrogel dressings with simple technology, good physical properties and biological effects by using natural polymers. Results In this study, a gelatin-based (Tsg-THA&Fe) hydrogel was created by mixing trivalent iron (Fe3+) and 2,3,4-trihydroxybenzaldehyde (THA) to form a complex (THA&Fe), followed by a simple Schiff base reaction with tilapia skin gelatin (Tsg). The gel time and rheological properties of the hydrogels were adjusted by controlling the number of complexes. The dynamic cross-linking of the coordination bonds (o-phthalmictriol-Fe3+) and Schiff base bonds allows hydrogels to have good self-healing and injectable properties. In vitro experiments confirmed that the hydrogel had good biocompatibility and biodegradability as well as adhesion, hemostasis, and antibacterial properties. The feasibility of Tsg-THA&Fe hydrogel was studied by treating rat skin trauma model. The results showed that compared with Comfeel® Plus Transparent dressing, the Tsg-THA&Fe hydrogel could obvious reduce the number of microorganisms, prevent bacterial colonization, reduce inflammation and accelerate wound healing. Local distribution of the Tsg-THA&Fe hydrogel in the skin tissue did not cause organ toxicity. Conclusions In summary, the preparation process of Tsg-THA&Fe hydrogel is simple, with excellent performance in physical properties and biological efficacy. It can effectively relieve inflammation and control the colonization of wound microbes, and can be used as a multi-functional dressing to improve wound healing. Graphical Abstract

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“…Similar to chitosan, there were typical amino peaks in the range 3200-3500 cm −1 , but there were large numbers of imine groups in gelatin, so there was no obvious peak similar to those of chitosan. In addition, there was a strong peak at 1720 cm −1 , which confirmed that there were more carbonyl groups in gelatin [19]. Then, we compared the main functional groups of modern commercial ink and antique ink (Fig.…”

Section: Analyses Of the Properties Of Gelatin Chitosan And Inksmentioning

confidence: 92%

“…As shown in Fig. 2B, gelatin is composed of various protein segments, so it contained many of the common functional groups of proteins, such as amino groups, carboxyl groups and even disulfide bonds [18,19]. Similar to chitosan, there were typical amino peaks in the range 3200-3500 cm −1 , but there were large numbers of imine groups in gelatin, so there was no obvious peak similar to those of chitosan.…”

Section: Analyses Of the Properties Of Gelatin Chitosan And Inksmentioning

confidence: 99%

Reproducing ancient Chinese ink depending on gelatin/chitosan and modern experimental methodology

Liu

2022

Herit Sci

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Chinese ink has very special significance for presentation of artistic effects and preservation of works of art; however, wasted nonrenewable resources, potential toxicity, and complex and inefficient production technologies have limited the development of inks for traditional Chinese culture. Herein, environmentally friendly, practical and antibacterial Chinese ink was prepared by facile heating-stirring of gelatin and the natural polysaccharide chitosan. The internal composition, viscosity, morphology, particle size and antibacterial properties of the ink were characterized by Fourier transform-infrared spectroscopy, X-ray photoelectron spectroscopy, scanning electron microscopy and bacteriostatic zone tests. The results showed that commercial ink (CM) spread easily on Xuan paper and led to imperfect artwork, while the chitosan and gelatin ink (CG) showed good adhesion and stability on Xuan paper. Based on this study, we believe that the good performance of CG ink should be attributed to restrictions arising from its internal chitosan and gelatin network, which restrict diffusion. Finally, the author used CG ink to display traditional Chinese calligraphy and landscape painting and believes that it has significant application prospects and will be used in large-scale production.

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Novel microsphere-packing synthesis, microstructure, formation mechanism and in vitro biocompatibility of porous gelatin/hydroxyapatite microsphere scaffolds

Cited by 29 publications

References 32 publications

3D printed gelatin/decellularized bone composite scaffolds for bone tissue engineering: Fabrication, characterization and cytocompatibility study

3D printed gelatin/decellularized bone composite scaffolds for bone tissue engineering: Fabrication, characterization and cytocompatibility study

A physicochemical double-cross-linked gelatin hydrogel with enhanced antibacterial and anti-inflammatory capabilities for improving wound healing

Reproducing ancient Chinese ink depending on gelatin/chitosan and modern experimental methodology

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