Novel microvascular invasion-based prognostic nomograms to predict survival outcomes in patients after R0 resection for hepatocellular carcinoma

Feng, Long-Hai; Dong, Hui; Lau, W. Y.; Yu, Hua; Zhu, Yuyao; Zhao, Yun; Lin, Yuxi; Chen, Jia; Wu, Mengchao; Wang, Cong

doi:10.1007/s00432-016-2286-1

Cited by 115 publications

(105 citation statements)

References 24 publications

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“…The presence of MVI has been confirmed to be associated with intrahepatic metastasis, and the risk of MVI increasing with tumor size and tumor numbers . Literatures had showed that MVI was detected in 15.0%‐57.1% of HCC, and 60%‐90% of tumor sizes greater than 5 cm .…”

Section: Discussionmentioning

confidence: 93%

Nomograms to predict the long‐time prognosis in patients with alpha‐fetoprotein negative hepatocellular carcinoma following radical resection

Huang

Liu

et al. 2020

Cancer Medicine

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Background:To develop and validate nomograms that can be used to predict outcomes in individuals suffering alpha-fetoprotein (AFP) negative hepatocellular carcinoma (HCC) after radical resection. Methods: A total of 509 AFP-negative HCC patients who in our center were randomized into training and validation cohorts. Nomograms for both overall and recurrence-free survival (OS and RFS, respectively) were established based on the predictors in the training cohort. Nomograms performance and discriminative power were assessed with concordance index (C-index) values and decision curve analyses (DCA). The results were validated in the validation cohort. Results: Alkaline phosphatase, liver cirrhosis, tumor size, satellite lesions, microvascular invasion, and Edmondson-Steiner grade were significantly linked to OS and RFS. Sex and tumor number were additional predictors for RFS. The OS nomogram had a C-index value of 0.742, which was better than that for the AJCC eighth edition (0.632), BCLC system (0.553), and JIS score (0.557) (all P < .001). The RFS nomogram C-index was 0.669, which was also superior to that of the AJCC eighth (0.608), BCLC stage (0.554), JIS score (0.551), and model of Gan et al (0.636) (P < .05 for all). Calibration curves indicated a good agreement between observed actual outcomes and predicted values. Kaplan-Meier curves and DCA indicated that nomograms were powerful in discrimination and clinical usefulness. These results were supported by the validation cohort. Conclusions: These nomograms presented more accurate prognostic prediction in patients with AFP-negative HCC after hepatectomy. K E Y W O R D Salpha-fetoprotein, carcinoma, hepatectomy, hepatocellular, nomogram 2792 | HUANG et Al.

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Section: Discussionmentioning

confidence: 93%

Nomograms to predict the long‐time prognosis in patients with alpha‐fetoprotein negative hepatocellular carcinoma following radical resection

Huang

Liu

et al. 2020

Cancer Medicine

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“…However, this referenced study did not consider differences in baseline characteristics, which might influence the prognosis analysis . In addition, the presence of MVI is widely reported to be a significant prognostic factor for HCC . Even for patients with small HCCs up to 3 cm, MVI enhances the rate of tumor recurrence and dramatically shortens long‐term survival .…”

Section: Introductionmentioning

confidence: 98%

“…8 In addition, the presence of MVI is widely reported to be a significant prognostic factor for HCC. [9][10][11] Even for patients with small HCCs up to 3 cm, MVI enhances the rate of tumor recurrence and dramatically shortens long-term survival. 12,13 Meanwhile, the tumor biology and condition of the underlying liver, instead of tumor size, were determined to be better indicators of the prognosis and should be given more attention.…”

Section: Introductionmentioning

confidence: 99%

Microvascular invasion predicts a poor prognosis of solitary hepatocellular carcinoma up to 2 cm based on propensity score matching analysis

Wang

2018

Hepatology Research

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“…Numerous studies have revealed that vascular invasion is an independent risk factor for the prognosis of HCC patients who underwent surgical treatment [22][23][24]. The presence of vascular invasion of the portal or hepatic veins is associated with a high risk of tumour recurrence and is regarded as a prerequisite for systemic tumour dissemination [25,26].…”

Section: Discussionmentioning

confidence: 99%

Role of the E3 Ubiquitin Ligase TRIM4 in Predicting the Prognosis of Hepatocellular Carcinoma

Dong¹,

Zhou²,

Sun³

et al. 2020

J. Cancer

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The E3 ubiquitin ligase TRIM4 has been reported to regulate the assembly of the antiviral signalling complex, induce mitochondrial aggregation and sensitize cells to H 2 O 2 -induced death. However, the relationship between TRIM4 and human malignancies, including hepatocellular carcinoma (HCC), is unclear. In this study, we detected the expression of TRIM4 in 134 pairs of HCC tissues and peritumoural tissues and investigated the association of TRIM4 expression with the prognosis of HCC. We found that the TRIM4 expression was much lower in HCC tissues than in peritumoural tissues and was significantly associated with vascular invasion, tumour capsule and Hong Kong Liver Cancer (HKLC) stage. Univariate and multivariate analyses revealed that the TRIM4 expression was an independent prognostic factor for overall survival (OS) and recurrence-free survival (RFS) in our HCC cohort. Patients with higher TRIM4 expression had a lower incidence of intrahepatic recurrence and a higher OS rate (p<0.001 and p<0.01, respectively). These results were further validated in another independent cohort of 200 HCC patients. In conclusion, the TRIM4 level in HCC tissues is an independent prognostic factor for HCC patients. Close clinical monitoring is recommended for patients with low TRIM4 expression.

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Novel microvascular invasion-based prognostic nomograms to predict survival outcomes in patients after R0 resection for hepatocellular carcinoma

Abstract: The novel classification system of MVI and the nomograms enabled more accurate predictions of risk of tumor recurrence and overall survival in patients with HCC after R0 liver resection.

Cited by 115 publications

References 24 publications

Nomograms to predict the long‐time prognosis in patients with alpha‐fetoprotein negative hepatocellular carcinoma following radical resection

Nomograms to predict the long‐time prognosis in patients with alpha‐fetoprotein negative hepatocellular carcinoma following radical resection

Microvascular invasion predicts a poor prognosis of solitary hepatocellular carcinoma up to 2 cm based on propensity score matching analysis

Role of the E3 Ubiquitin Ligase TRIM4 in Predicting the Prognosis of Hepatocellular Carcinoma

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