Novel modalities of delivering herbal medicines for wound healing: A review

Abstract

BackgroundThroughout the classical era, medicinal plants have already been employed as a resource for medicine and in the healing of wounds. Chronic wounds are linked to significant healthcare and socioeconomic consequences despite standard medication. The development of effective wound‐healing therapies with improved wound repair mechanisms may result from the emergence of innovative wound‐healing techniques utilizing medicinal plants in combination with nanotechnology. This review combines herbal formulations like biodegradable nanoparticles, films, fibres, hydrogels, and ointments with antibacterial, antioxidant, and anti‐inflammatory characteristics with herbal medicines to promote wound healing.ObjectiveThis article aims to provide an overview of the numerous cellular and molecular elements involved in skin healing.FindingsThis article overviews the numerous cellular and molecular elements involved in skin healing. Following the commencement of a tissue lesion, a series of molecular and cellular actions take place to restore the injured tissue. This process is known as regeneration and tissue repair. Sequential events involving the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells result in the exudative, proliferative, and extracellular matrix remodelling stages.ConclusionThe development of tissue edema is aided by exudative processes after damage. By recruiting myofibroblasts and fibroplasia, the proliferative stage aims to decrease the area of tissue damage. The mechanisms of angiogenesis and re‐epithelialization are still observed at this point.

The wound healing effect of polycaprolactone-chitosan scaffold coated with a gel containing Zataria multiflora Boiss. volatile oil nanoemulsions

“…On the other hand, applications of sustained drug delivery systems in regenerative medicine, especially in wound healing, have increased drastically [33][34][35][36]. Meanwhile, the use of herbal medicinal extracts in wound healing has attracted the attention of many researchers due to its advantages, such as few side effects, ease of extraction, and reasonable price [37,38]. Amongst, Zataria Multiflora Boiss (ZM), called in Persian "Shirazi thyme", has anti-inflammatory, antioxidant, and immunomodulatory effects, making it a suitable option for use in wound healing scaffolds [39][40][41].…”