Airborne equipment suffers a large overloaded force frequently due to the high dynamic characteristic of the airplane. To improve the performance of vibration isolation for overloaded payloads, an adaptive negative stiffness and sky-hook damping (ANS-SHD) control strategy is proposed based on a hybrid actuating system. The configuration and dynamic model of the system is illustrated and a simulation model of vibration isolation for time-variant payload with immense extents is established to validate the ability of proposed strategy. The simulation results demonstrate that the proposed strategy has a significant superiority compared with the sky-hook damping (SHD) control at 2-50 Hz and the vibration can be attenuated by 92.2% under the random excitation.