Novel mono-, bi-, tri- and tetra-nuclear copper complexes that inhibit tumor growth through apoptosis and anti-angiogenesis

Wang, Xiaojun; Zhu, Minghui; Li, Shanhe; Xu, Gang; Zhang, Zhenlei; Yang, Feng

doi:10.1016/j.jinorgbio.2023.112403

Cited by 10 publications

(13 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, since the Pt complex effectively reduced the expression of Bcl-2, the relative level of Beclin-1 increased, leading to autophagy in tumor cells. At the same time, our previous studies showed that metal complexes can inhibit tumor angiogenesis by inducing lethal autophagy of vascular endothelial cells . In this study, platinum complexes exert antitumor activity through the combination of these three modes of actions.…”

Section: Resultsmentioning

confidence: 65%

See 1 more Smart Citation

Human Serum Albumin-Platinum(II) Agent Nanoparticles Inhibit Tumor Growth Through Multimodal Action Against the Tumor Microenvironment

Xu,

Luo,

Zhu

et al. 2023

Mol. Pharmaceutics

Self Cite

View full text Add to dashboard Cite

To overcome the limitations of traditional platinum (Pt)-based drugs and further improve the targeting ability and therapeutic efficacy in vivo, we proposed to design a human serum albumin (HSA)-Pt agent complex nanoparticle (NP) for cancer treatment by multimodal action against the tumor microenvironment.We not only synthesized a series of Pt(II) di-2-pyridone thiosemicarbazone compounds and obtained a Pt(II) agent [Pt-(Dp44mT)Cl] with significant anticancer activity but also successfully constructed a novel HSA−Pt(Dp44mT) complex nanoparticle delivery system. The structure of the HSA−Pt(Dp44mT) complex revealed that Pt(Dp44mT)Cl binds to the IIA subdomain of HSA and coordinates with His-242. The HSA-His242-Pt-Dp44mT NPs had an obvious effect on the inhibition of tumor growth, which was superior to that of Dp44mT and Pt(Dp44mT)Cl, and they had almost no toxicity. In addition, the HSA-His242-Pt-Dp44mT NPs were found to kill cancer cells by inducing apoptosis, autophagy, and inhibiting angiogenesis.

show abstract

Section: Resultsmentioning

confidence: 65%

“…At the same time, our previous studies showed that metal complexes can inhibit tumor angiogenesis by inducing lethal autophagy of vascular endothelial cells. 59 In this study, platinum complexes exert antitumor activity through the combination of these three modes of actions.…”

Section: Targeting Ability Of Hsa-his242-pt-dp44mt Nps In Vivomentioning

confidence: 97%

Human Serum Albumin-Platinum(II) Agent Nanoparticles Inhibit Tumor Growth Through Multimodal Action Against the Tumor Microenvironment

Xu,

Luo,

Zhu

et al. 2023

Mol. Pharmaceutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…As one of the important trace elements in the human body is copper, copper acts as an important role in many cellular mechanisms and signaling pathways. According to reports, active copper-based complexes have been reported to display multiple biological roles such as antitumor, − inhibition of tumor angiogenesis, − anti-inflammation, antivirus, , and even can load siRNA into tumor cells and vascular endothelial cells to perform the synergistic effect of vector chemotherapy and siRNA gene therapy . Early copper-based complex anticancer agents are mainly DNA-targeting drugs, topoisomerase I, II inhibitors, and proteasome inhibitors, while multifunctional anticancer copper-based complexes with synergistic effects of antitumor angiogenesis, anti-inflammation, and killing tumor cells have rarely been reported.…”

Section: Introductionmentioning

confidence: 99%

Arene–Arene Coupled Disulfamethazines (or Sulfadiazine)-Phenanthroline-Metal(II) Complexes were Synthesized by In Situ Reactions and Inhibited the Growth and Development of Triple-Negative Breast Cancer through the Synergistic Effect of Antiangiogenesis, Anti-Inflammation, Pro-Apoptosis, and Cuproptosis

Xu,

Jin,

Liu

et al. 2024

J. Med. Chem.

View full text Add to dashboard Cite

The novel metal(II)-based complexes HA-Cu, HA-Co, and HA-Ni with phenanthroline, sulfamethazine, and aromatic−aromatic coupled disulfamethazines as ligands were synthesized and characterized. HA-Cu, HA-Co, and HA-Ni all showed a broad spectrum of cytotoxicity and antiangiogenesis. HA-Cu was superior to HA-Co and HA-Ni, and even superior to DDP, showing significant inhibitory effect on the growth and development of tripe-negative breast cancer in vivo and in vitro. HA-Cu exhibited observable synergistic effects of antiproliferation, antiangiogenesis, anti-inflammatory, pro-apoptosis, and cuproptosis to effectively inhibited tumor survival and development. The molecular mechanism was confirmed that HA-Cu could downregulate the expression of key proteins in the VEGF/VEGFR2 signaling pathway and the expression of inflammatory cytokines, enhance the advantage of pro-apoptotic protein Bax, and enforce cuproptosis by weakening the expression of FDX1 and enhancing the expression of HSP70. Our research will provide a theoretical and practical reference for the development of metal-sulfamethazine and its derivatives as chemotherapy drugs for cancer treatment.

show abstract

“…One group of Schiff bases that have attracted a great deal of research attention due to their medical application in the treatment of such feared diseases as leprosy and tuberculosis in the 1950s are thiosemicarbazones (TSCs) and they also have antiviral, antibacterial, anticancer, anti-inflammatory, antimalarial, and anti-HIV activity [9,10]. They can also be used for metal analysis, device applications related to telecommunications, optical computing, storage, and information processing [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Structural Characterization and Electrochemical Properties of Copper(II) Complexes with Functionalized Thiosemicarbazones Derived from 5-Acetylbarbituric Acid

Castiñeiras,

Fernández-Hermida,

García-Santos

et al. 2024

Preprint

View full text Add to dashboard Cite

The reaction between 5-acetylbarbituric acid and 4-dimethylthiosemicarbazide or 4-hexamethyleneiminyl thiosemicarbazide produces 5-acetylbarbituric-4-dimethylthiosemicarbazone (H2AcbDM) and 5-acetylbarbituric-4N-hexamethyleneiminyl thiosemicarbazone (H2Acbhexim). Eight new complexes with different cooper (II) salts have been prepared and characterized using elemental analysis, molar conductance, UV–vis, ESI-HRMS, FT-IR, magnetic moment, EPR and cyclic voltammetry. In addition, three-dimensional molecular structures of [Cu(HAcbDM)(H2O)2](NO3)·H2O (3a), [Cu(HAcbDM)(H2O)2]ClO4 (4), and [Cu(HAcbHexim)Cl] (6) were determined by single crystal X-ray crystallography, and was carried out an analysis of their supramolecular structure. The H-bonded assemblies were further studied energetically using DFT calculations, MEP surface and QTAIM analyses. In these complexes, the thiosemicarbazone coordinates to the metal ion in an ONS-tridentate manner, in the O-enolate/S-thione form. The electrochemical behavior of the thiosemicarbazones and their copper(II) complexes has been investigated at room temperature using the cyclic voltammetry technique in DMFA. The Cu(II)/Cu(I) redox system was found to be consistent with the quasi-reversible diffusion-controlled process.

show abstract

Novel mono-, bi-, tri- and tetra-nuclear copper complexes that inhibit tumor growth through apoptosis and anti-angiogenesis

Cited by 10 publications

References 64 publications

Human Serum Albumin-Platinum(II) Agent Nanoparticles Inhibit Tumor Growth Through Multimodal Action Against the Tumor Microenvironment

Human Serum Albumin-Platinum(II) Agent Nanoparticles Inhibit Tumor Growth Through Multimodal Action Against the Tumor Microenvironment

Synthesis, Structural Characterization and Electrochemical Properties of Copper(II) Complexes with Functionalized Thiosemicarbazones Derived from 5-Acetylbarbituric Acid

Contact Info

Product

Resources

About