Novel monodisperse PEG-grafted polystyrene resins: synthesis and application in gel-phase 13C NMR spectroscopy

Synthesis and Application of Monodisperse Oligo(Oxyethylene)-Grafted Polystyrene Resins for Solid-Phase Organic Synthesis

“…As shown in preliminary research, swelling properties, loading (Table ) and gel-phase NMR characteristics have been demonstrated to be excellent . As a result, resin 4d with eight ethylene glycol units has shown the best performance in terms of loading capacity combined with spectral quality.…”

“…Finally, we present a convenient three-step synthesis: monoprotection of glycols, attachment to solid-phase and deprotection. This synthetic approach as well as the implications of the linker length for the 13 C gel-phase NMR spectroscopy have previously been reported by our group . However, the full experimental details and a characterization of the resins are given in this manuscript.…”

“…Finally, for the deprotection, resins 3a – f were swollen in THF and treated with a solution of TBAF in THF to give monodisperse PEG-grafted resins 4a – f in quantitative yield as determined by 13 C gel-phase NMR spectroscopy (Figure ). For a systematic investigation of the effect of the PEG group length on the quality of gel-phase 13 C NMR spectra, a sensor molecule (4-(dimethylamino)-butanoic acid, hydrochloride) was attached and resulted in resins 5a – f . The sensor molecule was attached to the resins’ hydroxyl groups using a carbodiimide-based coupling method…”

Effective Reaction Monitoring of Intermediates by ATR-IR Spectroscopy Utilizing Fibre Optic Probes

“…The physical and chemical properties of these modified materials often depend to a large extent on the number of repetition units of the OEG moiety. For a systematic investigation of the influence of chain length, novel polystyrene-oligo(oxyethylene) graft copolymers containing monodisperse OEG units have been synthesized (Braunshier et al, 2008). For the preparation of these resins, access to well-defined oligo(ethylene glycols) of up to 12 units was required.…”

Copolumers obtained by grafting of vinyl monomers on starch - influence of amines on synthesis and degradation processes in environment

“…Kalemljeni kopolimer PEG i PS je dobijen uz korišćenje praha bakra i KOH kao katalizatora u N,N-dimetilformamidu (DMF-u) na 140-150 0 C pri trajanju reakcije od 6 h [95]. Kalemljeni kopolimeri PEG-a i PS mogu se koristiti kao smola u gel-faznoj 13 C NMR spektroskopiji [96] i kao smola koja podrţava sintezu peptida u čvrstoj fazi [97]. Pored ovih primena PEG kalemljen na PS se moţe koristiti i u biomedicini kao model sistem za proučavanje veštačkih ćelija [98,99].…”