Novel nanocapsule of α‐lipoic acid reveals pigmentation improvement: α‐Lipoic acid stimulates the proliferation and differentiation of keratinocyte in murine skin by topical application

Kubota, Yoshiki; Musashi, Mina; Nagasawa, Teruaki; Shimura, Nanako; Igarashi, Rie; Yamaguchi, Yoko

doi:10.1111/exd.13828

“…Developed novel nanocapsule of ALA, named α-Lipoactive (nLA), to improve skin permeability. In in vivo experiments, it was found that nLA is very effective for improving UV-induced pigmentation and epidermal thickening [151]. Demonstrated application of topical 30% poloxamer gel loaded with ALA cubosomes.…”

Section: G α-Lipoic Acidmentioning

confidence: 99%

Skin Aging and Modern Age Anti-Aging Strategies

AK¹

2019

Austin J Womens Health

0

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As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. With intrinsic aging, structural changes occur in the skin as a natural consequence of the biological changes over time and produce a certain number of histological, physiological, and biochemical modifications. Intrinsic aging is determined genetically (influence of gender and ethnic group), variable in function of skin site, and also influenced by hormonal changes. Visually it is characterized by fine wrinkles. By comparison, "photoaging" is the term used to describe the changes occurring in the skin, resulting from repetitive exposure to sunlight. The histological, physiological, and biochemical changes in the different layers of the skin are much more drastic. From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below the much more compliant adjacent layer of subcutaneous white adipose tissue. Upon exposure to a strain, such a multilayer system demonstrates structural instabilities in its stiffer layers, which in its simplest form is the wrinkling. These instabilities appear hierarchically when the mechanical strain in the skin exceeds some critical values. Their appearance is mainly dependent on the mismatch in mechanical properties between adjacent skin layers or between the skin and subcutaneous white adipose tissue, on the adhesive strength and thickness ratios between the layers, on their bending and tensile stiffness as well as on the value of the stress existing in single layers. Gradual reduction of elastic fibers in aging significantly reduces the skin's ability to bend, prompting an up to 4-fold reduction of its stability against wrinkling, thereby explaining the role of these fibers in skin aging. Anti-aging medicine is practiced by physicians, scientists, and researchers dedicated to the belief that the process of physical aging in humans can be slowed, stopped, or even reversed through existing medical and scientific interventions. This specialty of medicine is based on the very early detection and prevention of age-related diseases. Physicians practicing anti-aging medicine seek to enhance the quality of life as well as its length, limiting the period of illness and disability toward the end of one's life. Anti-aging medicine encompasses lifestyle changes (diet and exercise); hormone replacement therapies, as needed, determined by a physician through blood testing (DHEA, melatonin, thyroid, human growth hormone, estrogen, testosterone); antioxidants and vitamin supplements;...

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“…If we can be mesmerized by the plethora of experimental models and assays for human skin pigmentation control, the sheer snowstorm of touted melanogenesis agents used in these assays can be enthralling if not bamboozling. These range from the exotically and dare I say hypnotically named botanicals 10–12 to the repackaging of some of our own human elixiric juices, for example taken from either our intra‐uterine lives (eg placental extracts 13,14 ) or from our increasingly appreciated super‐lipids 9,15 . My own laboratory has indulged a bit in this area too, 12 but journal editors are increasingly taking a jaundiced view of this area of skin and hair science, as it is just so difficult to separate the wheat from the chaff; the clinically relevant pigmentation modulator from the, well, sadly: “figment‐modulators”.…”

Section: Figurementioning

confidence: 99%

How to design robust assays for human skin pigmentation: A “Tortoise and Hare challenge”

Tobin

¹

2021

Experimental Dermatology

2

0

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“…Though ALA is normally administered in oral or injection, it is rarely used topically because of its bad penetration. Kubota et.al, 2019 developed novel nanocapsule of ALA, named α-lipoactive (nLA), to improve skin permeability.In in vivo experiments, it was found that nLA is very effective for improving UV-induced pigmentation and epidermal thickening [151]. Sherif et.al, 2019 demonstrated application of topical 30% poloxamer gel loaded with ALA cubosomes.…”

Section: G α-Lipoic Acidmentioning

confidence: 99%

Skin Aging & Modern Age Anti-aging Strategies

Mohiuddin¹

2019

GJMR

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As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. With intrinsic aging, structural changes occur in the skin as a natural consequence of the biological changes over time and produce a certain number of histological, physiological, and biochemical modifications. Intrinsic aging is determined genetically (influence of gender and ethnic group), variable in function of skin site, and also influenced by hormonal changes. Visually it is characterized by fine wrinkles. By comparison, “photoaging” is the term used to describe the changes occurring in the skin, resulting from repetitive exposure to sunlight. The histological, physiological, and biochemical changes in the different layers of the skin are much more drastic. From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below the much more compliant adjacent layer of subcutaneous white adipose tissue.

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Novel nanocapsule of α‐lipoic acid reveals pigmentation improvement: α‐Lipoic acid stimulates the proliferation and differentiation of keratinocyte in murine skin by topical application

Cited by 18 publications

References 25 publications

Skin Aging and Modern Age Anti-Aging Strategies

Skin Aging and Modern Age Anti-Aging Strategies

How to design robust assays for human skin pigmentation: A “Tortoise and Hare challenge”

Skin Aging & Modern Age Anti-aging Strategies

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