Novel Nanocarriers for Ethnopharmacological Formulations

Sivapriya, V.; Ponnarmadha, S.; Nazeer, Abdul Azeez; Sudarshanadeepa, V.

doi:10.22159/ijap.2018v10i4.26081

Cited by 13 publications

(13 citation statements)

References 48 publications

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“…These standards are designed to establish the allowed packaging processes and propose a sustainable extraction and allowed processes [109][110][111][112]. Various challenges in formulating herbal cosmetics have been overcome through various novel delivery systems [113][114].…”

Section: Discussionmentioning

confidence: 99%

Challenges in Formulating Herbal Cosmetics

D.k.

Jain

2018

Int J App Pharm

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The herbal cosmetics are prepared by phytochemicals that occur in a variety of botanical sources, that influences the physiology of skin and provide nutrients that are necessary for the healthy skin or hair. These products are utilized for daily purposes, which include herbal shampoo, herbal conditioner, herbal face wash, herbal soap, etc. These products are classified as a different category by regulatory agencies. However, guidelines of these certifying agencies have no harmonization, and many cosmetic industries prepare and package these formulations in an irrationalway. Many cosmetic products have natural products in their formulation that perform a specific biological function, but these products should be evaluated on their toxicological and efficacy aspects. The contribution of developing countries is very poor in global herbal business because of lack of standardization measures and quality control. The lack of safety and efficacy data on herbal cosmetics renders it difficult to meet the criteria needed for supporting its use worldwide. This review article discusses challenges related to regulatory status, quality control, standardization, certification, drug processing and the opportunities for herbal cosmetics in local as well as the global scenario. The search criteria used in the present review were the keywords mentioned in the manuscript and articles from major scientific resources were cited. The articles from 1952 to 2018 were specifically referred, but few references from 19 century were also cited to support the prevalence of scientific principles in the development of herbal cosmetics in the ancient era.

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Section: Discussionmentioning

confidence: 99%

Challenges in Formulating Herbal Cosmetics

D.k.

Jain

2018

Int J App Pharm

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“…The PLNs development for Cinnamomum burmanii extract is expected to be a prospectus formula for further study on its efficacy on the animal model. Nanotechnology applied to herbal delivery has a profound impact on its permeability and bioavailability [16].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Study on the Impact of Polymer-Lipid Types and Ratio to Polymeric-Lipid Hybrid Nanoparticle

et al. 2021

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Objective: This study aims to determine the best lipid to polymer ratios in polymeric-lipid nanoparticles using various types and ratios of polymers and lipids. Method: Polymeric-lipid nanoparticle was prepared using the modified one-step nanoprecipitation method. This study used chitosan and Na alginate as polymers and lecithin and egg phosphatidylcholine as lipids. The lipid was crossed-combined with polymer in various ratios, i. e 12.5%, 25.0%, and 37.5%. On its preparation, Cinnamomum burmanii extract was loaded into the resulted polymeric-lipid nanoparticle as an active substance model. The results were assessed its particle surface characteristics including particle size, polydispersity index, and zeta potential. Results: Twelve formulas resulted from crossed-combination between the lipid and polymer were used in this study. Polymeric-lipid nanoparticles resulted from the combination of egg phosphatidylcholine/Na alginate has particle size, polydispersity index, and zeta potential of 380.07±3.52 nm, 0.66±002, and-30.6±1.15 mV, respectively. Conclusions: The best lipid to polymer ratio and type was observed in egg phosphatidylcholine: Na alginate. The particle surface characteristics were better compared to other combinations.

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“…Nanostructured lipid carriers (NLCs) could be a solution to the problem of the short residence time of topical eye drops for DED [9]. In particular, the NLCs made from lipid assemblages have been shown to have strong mucoadhesiveness to corneal epithelium [10][11][12]. This means that they have a higher dwell time in the eye and hence could release its lipids through disintegration over a much longer period.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Nanostructured Lipid Carriers With Human Meibum

et al. 2019

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Objective: This study aimed to determine the possibility of nanostructured lipid carriers (NLCs) as a bionic tear film by determining the surface activities of the developed NLCs and their interaction with human meibomian lipid films. Methods: NLCs with different types of solid lipids and surfactants were prepared by a high-pressure homogenizer. The particle size was determined by dynamic light scattering. The surface activities of the NLCs and NLCs mixed with meibomian lipids were measured using a Langmuir trough and the resulting surface pressure area (Π-A) profiles were compared. These lipid films were further analyzed using fluorescence microscopy and scanning electron microscopy (SEM). Results: The particle size of prepared NLCs varied from 38–280 nm based on types of solid lipid and surfactant. All NLCs were highly surface active as indicated by their maximum surface pressure (Πmax). The Π-A profiles of meibum seeded with NLCs showed higher surface pressure than meibum alone and the shape of profiles were dominated by the meibomian lipids. These findings were in agreement with fluorescence and SEM micrographs, which revealed that the NLCs could adsorb and integrate to the meibomian lipid films as well as diffuse from the subphase to the lipid films. Conclusion: NLCs are surface active and can integrate with meibomian lipid films formed stable films. The type of interaction can be tailored by altering the solid lipids used in the formulation of the NLCs which could provide the means to develop efficient formulations for targeting dry eye disease related to a non-functional tear film lipid layer.

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Novel Nanocarriers for Ethnopharmacological Formulations

Cited by 13 publications

References 48 publications

Challenges in Formulating Herbal Cosmetics

Challenges in Formulating Herbal Cosmetics

Preliminary Study on the Impact of Polymer-Lipid Types and Ratio to Polymeric-Lipid Hybrid Nanoparticle

Interaction of Nanostructured Lipid Carriers With Human Meibum

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