Novel nanofibrous electrically conductive scaffolds based on poly(ethylene glycol)s-modified polythiophene and poly(ε-caprolactone) for tissue engineering applications

Hatamzadeh, Maryam; Najafi-Moghadam, Peyman; Baradar-Khoshfetrat, Ali; Jaymand, Mehdi; Massoumi, Bakhshali

doi:10.1016/j.polymer.2016.11.012

Cited by 39 publications

(13 citation statements)

References 50 publications

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“…This allows us to manipulate a cell's behavior by altering the properties of its immediate environment. For example, by modifying the charge and wettability of a surface we can limit bacterial adhesion (Kohnen & Jansen, ; Terada, Okuyama, Nishikawa, Tsuneda, & Hosomi, ), and increasing the conductivity of a surface may cause some stem cells to activate differentiation mechanisms (Hatamzadeh, Najafi‐Moghadam, Baradar‐Khoshfetrat, Jaymand, & Massoumi, ; Yuan, Arkonac, Chao, & Vunjak‐Novakovic, ). As one of the main sources of contamination in the food processing industry is direct‐contact surfaces, such as those on knives, belts, production equipment, and containers (Marriott & Gravani, ), new bio‐active surfaces could be incorporated into processing equipment to provide cost‐effective, long‐term protection from food‐borne pathogens.…”

Section: Nanotechnology and Materials Science In Food Processingmentioning

confidence: 99%

“…For example, the differentiation rates of myoblasts seeded on scaffolds with incorporated polyaniline, an organic conductive polymer, were shown to increase as the concentrations of polyaniline increased in the scaffolds. Electrical stimulation of fibroblasts, myoblasts, and chondrocytes has been shown to increase their adhesion, differentiation, and ECM deposition (Hatamzadeh et al., ; Yuan et al., ). The electrical signals generated by the myoblasts could potentially transmit through the conductive polyaniline surface and provide a catalyst for differentiation.…”

Section: Nanotechnology and Materials Science In Food Processingmentioning

confidence: 99%

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Integration of Emerging Biomedical Technologies in Meat Processing to Improve Meat Safety and Quality

Ravensdale

Coorey

Dykes

2018

Comp Rev Food Sci Food Safe

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Modern-day processing of meat products involves a series of complex procedures designed to ensure the quality and safety of the meat for consumers. As the size of abattoirs increases, the logistical problems associated with large-capacity animal processing can affect the sanitation of the facility and the meat products, potentially increasing transmission of infectious diseases. Additionally, spoilage of food from improper processing and storage increases the global economic and ecological burden of meat production. Advances in biomedical and materials science have allowed for the development of innovative new antibacterial technologies that have broad applications in the medical industry. Additionally, new approaches in tissue engineering and nondestructive cooling of biological specimens could significantly improve organ transplantation and tissue grafting. These same strategies may be even more effective in the preservation and protection of meat as animal carcasses are easier to manipulate and do not have the same stringent requirements of care as living patients. This review presents potential applications of emerging biomedical technologies in the food industry to improve meat safety and quality. Future research directions investigating these new technologies and their usefulness in the meat processing chain along with regulatory, logistical, and consumer perception issues will also be discussed.

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Section: Nanotechnology and Materials Science In Food Processingmentioning

confidence: 99%

Section: Nanotechnology and Materials Science In Food Processingmentioning

confidence: 99%

Integration of Emerging Biomedical Technologies in Meat Processing to Improve Meat Safety and Quality

Ravensdale

Coorey

Dykes

2018

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

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“…These properties can be reached with the addition of a small amount (generally less than 10% wt/wt) 34 of a conductive polymer in the matrix. This factor is reflected in the low values of percolation limits obtained for most blends of these materials 35–37 …”

Section: Introductionmentioning

confidence: 99%

Development of scaffolds based in blends of poly(N‐vinylcaprolactam) and poly(N‐vinylcaprolactam‐co‐butylacrylate) with poly(3‐hexylthiophene) for tissue engineering: Synthesis, processing, characterization, and biological assay

Nahra

Oliveira

Macedo

et al. 2022

J of Applied Polymer Sci

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Conductive polymers can stimulate the adhesion and proliferation of several cell types being an interesting material to be applied in the field of tissue engineering. In this application, the addition of a thermosensitive polymer has been pointed out as an attractive strategy to improve mechanical strength and to provide conformation changes at temperature close to human body temperature. The main goal of this work was to evaluate the physical–chemical properties and promotion of cell proliferation and possible application as scaffolds for tissue engineering of blends of poly(N‐vinylcaprolactam) (PNVCL) and poly(N‐vinylcaprolactam‐co‐butylacrylate) (PNVCL‐co‐ABu) with poly(3‐hexylthiophene) (P3HT). Both polymers were synthesized and their chemical structures were confirmed by Fourier Transform Infrared (FT‐IR) and nuclear magnetic resonance (NMR) analyses. The materials were processed in films form for structural characterization, impedance measurements, and thermogravimetric analysis. The in vitro biological assays were performed using the materials as electrospun mats. The FT‐IR was also used to characterize the blends. The addition of P3HT did not change thermal stability and showed low conductivity values of the blends. Comparing the in vitro behavior of the blends and the polymers it was possible to conclude that the presence of P3HT improved cytocompatibility and promoted cell proliferation.

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“…Poly(ε-caprolactone) (PCL) is a biodegradable semi-crystalline polymer that has been widely used in tissue engineering [ 1 , 2 , 3 , 4 , 5 ]. The crystalline structure offers PCL unique thermal and mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Smooth Muscle Cell Responses to Poly(ε-Caprolactone) Triacrylate Networks with Different Crosslinking Time

Wang

Liu

Wang

et al. 2020

IJMS

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Poly(ε-caprolactone) triacrylate (PCLTA) is attractive in tissue engineering because of its good biocompatibility and processability. The crosslinking time strongly influences PCLTAs cellular behaviors. To investigate these influences, PCLTAs with different molecular weights were crosslinked under UV light for times ranging from 1 to 20 min. The crosslinking efficiency of PCLTA increased with decreasing the molecular weight and increasing crosslinking time which could increase the gel fraction and network stiffness and decrease the swelling ratio. Then, the PCLTA networks crosslinked for different time were used as substrates for culturing rat aortic smooth muscle cells (SMCs). SMC attachment and proliferation all increased when the PCLTA molecular weight increased from 8k to 10k and then to 20k at the same crosslinking time. For the same PCLTA, SMC attachment, proliferation, and focal adhesions increased with increasing the crosslinking time, in particular, between the substrates crosslinked for less than 3 min and longer than 5 min. This work will provide a good experimental basis for the application of PCLTA.

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Novel nanofibrous electrically conductive scaffolds based on poly(ethylene glycol)s-modified polythiophene and poly(ε-caprolactone) for tissue engineering applications

Cited by 39 publications

References 50 publications

Integration of Emerging Biomedical Technologies in Meat Processing to Improve Meat Safety and Quality

Integration of Emerging Biomedical Technologies in Meat Processing to Improve Meat Safety and Quality

Development of scaffolds based in blends of poly(N‐vinylcaprolactam) and poly(N‐vinylcaprolactam‐co‐butylacrylate) with poly(3‐hexylthiophene) for tissue engineering: Synthesis, processing, characterization, and biological assay

Smooth Muscle Cell Responses to Poly(ε-Caprolactone) Triacrylate Networks with Different Crosslinking Time

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