Novel nanomedicine-based MRI contrast agents for gynecological malignancies

Mody, Vicky; Nounou, Mohamed Ismail; Bikram, Malavosklish

doi:10.1016/j.addr.2009.04.020

Cited by 112 publications

(119 citation statements)

References 110 publications

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“…The endohedral fullerene's strong electronic properties can strongly enhance diagnostics. Such compounds are currently being investigated as a platform to detect cancer [63] , atherosclerosis [64] and arthritis [65] . Present day diagnostic limitations of both sensitivity and specificity have stalled progress on accurate, enhanced patient imaging.…”

Section: Fullerenes As Diagnosticsmentioning

confidence: 99%

Application of Fullerenes in Nanomedicine: An Update

Dellinger¹,

et al. 2013

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Abstract:Fullerenes are carbon spheres presently being pursued globally for a wide range of applications in nanomedicine. These molecules have unique electronic properties that make them attractive candidates for diagnostic, therapeutic and theranostic applications. Herein, the latest research is discussed on developing fullerene-based therapeutics as antioxidants for inflammatory diseases, their potential as antiviral/bacterial agents, utility as a drug delivery device and the promise of endohedral fullerenes as new MRI contrast agents. The recent discovery that certain fullerene derivatives can stabilize immune effector cells to prevent or inhibit the release of proinflammatory mediators makes them potential candidates for several diseases such as asthma, arthritis and multiple sclerosis. Gadolinium-containing endohedral fullerenes are being pursued as diagnostic MRI contrast agents for several diseases. Finally, a new class of fullerene-based theranostics has been developed, which combine therapeutic and diagnostic capabilities to specifically detect and kill cancer cells. Figure 1C). Fullerenes have a unique cage structure with delocalized π-molecular orbital electrons. This structure confers unusual activity in electron transfer systems due to their low reorganization energy, low lying excited states (singlet and triplet) and extended triplet lifetimes. Furthermore, the spherical configuration of the planar benzene rings imposes an

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Section: Fullerenes As Diagnosticsmentioning

confidence: 99%

Application of Fullerenes in Nanomedicine: An Update

Dellinger¹,

et al. 2013

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“…However, the direct use of magnetic nanoparticles as in vivo MRI contrast agent results in biofouling of the particles in blood plasma and formation of aggregates that are quickly sequestered by cells of the reticular endothelial system (RES) such as macrophages [16,17]. Furthermore, aggregated nanoparticles change their superparamagnetic response [7]. Therefore, in order to minimize biofouling and aggregation of particles and escape from the RES for longer circulation times, the nanoparticles are usually coated with a layer of hydrophilic and biocompatible polymer such as dextran [18], dendrimers [19], poly(ethylene glycol) (PEG) [20], and poly(vinyl pyrrolidone) (PVP) [21][22][23].…”

mentioning

confidence: 99%

Synthesis and characterization of PVP-functionalized superparamagnetic Fe3O4 nanoparticles as an MRI contrast agent

Arsalani¹,

Fattahi²,

Nazarpoor³

2010

Express Polym. Lett.

236

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Abstract. The magnetite (Fe3O4) nanoparticles (MNPs) coated with poly(N-vinyl pyrrolidone) (PVP) via covalent bonds were prepared as T2 contrast agent for magnetic resonance imaging (MRI). The surface of MNPs was first coated with 3-(trimethoxysilyl) propyl methacrylate (silan A) by a silanization reaction to introduce reactive vinyl groups onto the surface, then poly(N-vinyl pyrrolidone) was grafted onto the surface of modified-MNPs via surface-initiated radical polymerization. The obtained nanoparticles were characterized by FT-IR (Fourier transform infrared spectroscopy), XRD (X-ray diffraction), TEM (transmission electron microscopy), VSM (vibrating sample magnetometer), and TGA (thermogravimetric analysis). The MNPs had an average size of 14 nm and exhibited superparamagnetism and high saturation magnetization at room temperature. T2-weighted MRI images of PVP-grafted MNPs showed that the magnetic resonance signal is enhanced significantly with increasing nanoparticle concentration in water. The r1 and r2 values per millimole Fe, and r2/r1 value of the PVP-grafted MNPs were calculated to be 2.6 , 72.1, and 28.1(mmol/l) -1 ·s -1 , respectively. These results indicate that the PVP-grafted MNPs have great potential for application in MRI as a T2 contrast agent. Vol.4, No.6 (2010) 329-338 Available online at www.expresspolymlett.com DOI: 10.3144/expresspolymlett.2010.42 region that they are accumulated, and hence cause negative contrast and provide a dark state in the image where the compounds are accumulated [15]. However, the direct use of magnetic nanoparticles as in vivo MRI contrast agent results in biofouling of the particles in blood plasma and formation of aggregates that are quickly sequestered by cells of the reticular endothelial system (RES) such as macrophages [16,17]. Furthermore, aggregated nanoparticles change their superparamagnetic response [7]. Therefore, in order to minimize biofouling and aggregation of particles and escape from the RES for longer circulation times, the nanoparticles are usually coated with a layer of hydrophilic and biocompatible polymer such as dextran [18], dendrimers [19], poly(ethylene glycol) (PEG) [20], and poly(vinyl pyrrolidone) (PVP) [21][22][23]. Of synthetic polymers, PVP is water-soluble, non-charged, non-toxic, and is used in various medical applications [24]. While there is a potential concern about covalent interaction between hydrophilic polymers and magnetic nanoparticles in order to increase their stability in physiological medium [25][26][27][28][29], PVP coating on Fe 3 O 4 nanoparticles in all previous works has been achieved through noncovalent interaction. Now, polymers grafting of magnetic nanoparticles is one of the most attractive methods of surface modification [30,31]. In the present study, we carried out chemical synthesis and characterization of PVP-functionalized magnetite (Fe 3 O 4 ) nanoparticles. Since the PVP was bonded to the surface of magnetite nanoparticles through covalent bonds, the prepared magnetic fluid (ferrofluid) was ve...

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“…Usually, accumulation of contrast agents is essential to achieve MR imaging (MRI) and high-resolution images. 7,8 Most of contrast agents for MRI are based on either iron oxide particle or gadolinium (III) (Gd(III))-chelated complexes. Gd(III)-based contrast agents have a low r 2 /r 1 ratio and are frequently used to generate positive contrast (increased signal intensity) in T 1 -weighted images.…”

Section: 6mentioning

confidence: 99%

“…Recently, various nanoscale carriers such as liposomes, micelles, and polymeric nanoparticles have been modified or incorporated with the MRI contrast agent Gd(III). 8,9 Liposomal nanocarriers are able to carry multiple reporter moieties such as peptides and antibodies for the efficient and selective delivery of contrast agents into the pathological sites.…”

Section: 6mentioning

confidence: 99%

Dual Functional Gd(III)-DOTA Liposomes for Cancer Therapy and Diagnosis as a Theragnostic Carrier

Han¹,

Jung²,

Seong³

et al. 2013

Bulletin of the Korean Chemical Society

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Development of dual functional liposome has been studied for cancer theragnostics. Therefore, we focused on ultrasound-sensitive liposomes with doxorubicin (DOX) and gadolinium (Gd) as a theragnostic carrier having a potential for cancer therapy and diagnosis. In this study, Gd(III)-DOTA-modified sonosensitive liposomes (GL) was developed using chemically synthesized Gd(III)-DOTA-DPPE lipid. Sonosensitivity of GL to 1 MHz ultrasound induced 25% of DOX release. The relaxivities (r 1 ) of GL were 7.33-10.34 mM, which was higher than that of MR-bester ® . Intracellular delivery of DOX from GL by ultrasound irradiation was evaluated according to ultrasound intensity, resulting in increase of uptake of DOX released from ultrasoundtriggered GLs compared to GL3 or Doxil ® without ultrasound. Taken together, this study shows that the paramagnetic and sonosensitive liposomes, GL, is a novel and highly effective delivery system for drug with the potential for broad applications in human disease.

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Novel nanomedicine-based MRI contrast agents for gynecological malignancies

Cited by 112 publications

References 110 publications

Application of Fullerenes in Nanomedicine: An Update

Application of Fullerenes in Nanomedicine: An Update

Synthesis and characterization of PVP-functionalized superparamagnetic Fe3O4 nanoparticles as an MRI contrast agent

Dual Functional Gd(III)-DOTA Liposomes for Cancer Therapy and Diagnosis as a Theragnostic Carrier

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