Novel nanoparticle materials for drug/food delivery-polysaccharides

Chen, Lei; Liu, Xingxun; Wong, Ka Hing

doi:10.1515/psr-2016-0053

Cited by 8 publications

(4 citation statements)

References 219 publications

(170 reference statements)

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“… Slow medication release under neutral conditions and increased acidity helped to enhance tumor therapy. [ 94 ] P-Graft-Copolymers with poly (vinyl alcohol) and their NCs. 5-fluorouracil After 300 min in a phosphate buffer solution at pH 7.4 the NCs release was determined to be 93% and 99.1% of 5-fluorouracil respectively.…”

Section: Pectin and Its Modified Ncs For Drug Delivery Applicationsmentioning

confidence: 99%

Pharmaceutical and drug delivery applications of pectin and its modified nanocomposites

Kedir¹,

Deresa²,

Diriba³

2022

Heliyon

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Section: Pectin and Its Modified Ncs For Drug Delivery Applicationsmentioning

confidence: 99%

Pharmaceutical and drug delivery applications of pectin and its modified nanocomposites

Kedir¹,

Deresa²,

Diriba³

2022

Heliyon

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“…This hydrophilic molecular cage exhibits a hydrophobic interior that enables the encapsulation of hydrophobic molecules. Widely employed in diverse industries such as pharmaceuticals, agrochemicals, food, and cosmetics, , β-cyclodextrin can be structurally modified to yield various amphiphilic derivatives. , The inclusion of hydrophobic drugs within the hydrophobic cavities of amphiphilic cyclodextrins enhances their water solubility and bioavailability by facilitating the formation of drug delivery systems. , Furthermore, this approach allows for the creation of drug-loaded nanoparticles that prolong drug residence time in the body and enhance their effective utilization rate. − …”

Section: Introductionmentioning

confidence: 99%

“…29,30 The inclusion of hydrophobic drugs within the hydrophobic cavities of amphiphilic cyclodextrins enhances their water solubility 31 and bioavailability by facilitating the formation of drug delivery systems. 32,33 Furthermore, this approach allows for the creation of drug-loaded nanoparticles that prolong drug residence time in the body and enhance their effective utilization rate. 34−36 Our previous study demonstrated that insecticide nanoformulations, utilizing plant endogenous polymer materials as carriers, significantly enhance the systemic translocation of original insecticides in plants.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Systemic Translocation of Insecticides via Nanoformulations Incorporating β-Cyclodextrin Octadecarboxylate as a Carrier

Huang,

Xiong,

et al. 2024

J. Agric. Food Chem.

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The conversion of contact-killing pesticides into systemic pesticides can significantly enhance the bioavailability of pesticides, thereby reducing pesticide usage and environmental harm. A series of β-cyclodextrin fatty acid esters with varying branch chains were synthesized and employed as carriers in nanoformulation of insecticide. The investigation revealed that nanoformulations prepared using β-cyclodextrin octadecarboxylate (β-CDs) exhibited superior stability and remarkable systemic translocation within plants. Six contact-killing insecticide nanoformulations were developed utilizing β-CDs as carriers, and tests indicated that β-CDs significantly enhanced the systemic translocation of insecticides in plants compared to carrier-free nanoformulations. It was found that β-CDs increased the level of systemic translocation of insecticides by 5−12 times. Additionally, characterization results from λ-cyhalothrin-β-CDs nanoformulation demonstrated their superior ability to improve photolysis resistance, prolong release time, and extend insecticidal duration. Consequently, β-CDs can be utilized as a green additive in pesticide production to enhance the systemic translocation of pesticides in plants and increase their bioavailability.

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“…The polymers used are chitosan and k-carrageenan. These two opposite charge biopolymers can react to form polyelectrolyte 14,15) . Formation complex coacervation is start with adding the core material to polymer solutions, emulsification of this aqueous, adding the other polysaccharides along with dilution water, and following with adjusting the pH below the isoelectric point of protein to start electrostatic interactions and form agglomerates.…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of Rice Bran Oil by Complex Coacervation Using Chitosan – k-carrageenan: Influence of Glutaraldehyde and Tween 20

Fadilah¹,

Distantina²,

Susanti³

et al. 2023

Evergreen

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Rice bran oil (RBO) is obtained by extracting rice bran, a byproduct of the rice milling process. It contains vitamins, antioxidants, and nutrients that are very beneficial for the human body. In order to maintain its biological and functional characteristics, the microencapsulation technology is chosen. In this research the coacervation technique was applied using chitosan and k-carrageenan. The influence of the amount of glutaraldehyde as crosslinking agent and Tween 20 as emulsifying agent was studied. Research was conducting by dropping of solution of k-carrageenan containing RBO on the chitosan solution followed by adding glutaraldehyde. After washing and drying, the microcapsules were characterized by FTIR and SEM, and were analyzed for its yield and encapsulation efficiency. The FTIR shows that RBO was successfully loaded on the microcapsules. Analysis using SEM shows that micro-sized particles is not perfectly spherical, have irregular shape, rough surface and also agglomerated. The process has a yield of up 99.90 ± 1.29%. The highest encapsulation efficiency 66.49 ±4.8% was obtained from 0.5 mL Tween 20 and 0.5 mL glutaraldehyde. Increasing amount of glutaraldehyde tend to reduces the particle size since the wall became compact as degree of crosslinking increased. The amount of Tween 20 has little effect on encapsulation size.

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Novel nanoparticle materials for drug/food delivery-polysaccharides

Cited by 8 publications

References 219 publications

Pharmaceutical and drug delivery applications of pectin and its modified nanocomposites

Pharmaceutical and drug delivery applications of pectin and its modified nanocomposites

Enhancing Systemic Translocation of Insecticides via Nanoformulations Incorporating β-Cyclodextrin Octadecarboxylate as a Carrier

Microencapsulation of Rice Bran Oil by Complex Coacervation Using Chitosan – k-carrageenan: Influence of Glutaraldehyde and Tween 20

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