Novel nanoparticles for the delivery of recombinant hepatitis B vaccine

Characterization, blood profile and biodistribution properties of surface modified PLGA nanoparticles of SN-38

“…Recent reports have demonstrated that the uptake of PLGA NPs by the rapid reticuloendothelial system (RES) could be significantly reduced by modifying the surface of NPs with PEG. The PEG-modified PLGA NPs, prepared by using a di-block copolymer of PLGA-b-PEG as an additive, considerably prolonged their half-life in the circulation due to the presence of highly mobile and flexible PEG chains on the surface of the NPs (Kim et al, 2005;Kunii et al, 2007;Bharali et al, 2008). The colloid nature of the SN-38-loaded NPs possibly resulted in a notably increased uptake by RES organs, such as the liver and spleen.…”

Amino-Functionalized Silica Nanoparticles: In Vitro Evaluation for Targeted Delivery and Therapy of Pancreatic Cancer

“…e concentration of the released doxorubicin at each time point was determined using the Nanodrop UV spectrophotometer. e percent release of doxorubicin at each time point was calculated by using the equation [31]:…”

Immobilized ruthenium complexes and aspects of their reactivity

“…Some of the most widely used polymers for micro or nanoparticles preparation are PLA, PGA, and their co-polymer, PLGA [14,[87][88][89][90][91][92][93][94][95][96][97][98][99]. Two methods are commonly used for encapsulation of compounds in micro or nanoparticles, depending on the hydrophilic nature of the drug to be entrapped.…”

“…This would result in poor trapping of a hydrophilic drug, such as trans-[Ru(NO)(NH 3 ) 4 (py)](BF 4 ) 3 [14], and initial rapid release of the compound (burst effect) [94,95]. The double (multiple) emulsion process, which is a water-in-oil-in-water (w/o/w) method, is best suited for encapsulation of water-soluble compounds, such as peptides, proteins, and vaccines, unlike the o/w method, which is ideal for water-insoluble drugs, like steroids [91][92][93][96][97][98].…”